Benjamin Jackson's questions to Sanofi SA (SNY) leadership • Q1 2025
Question
Benjamin Jackson from Jefferies asked if positive brivekimig results in HS suggest utility in other indications and how this impacts portfolio positioning. He also asked if the oral TNFR1 inhibitor's psoriasis data changes expectations for the upcoming rheumatoid arthritis readout and its combination strategy.
Answer
Houman Ashrafian (EVP, Head of R&D) confirmed that molecular data from the brivekimig study provides leads for other indications. For the oral TNFR1 inhibitor, he explained the psoriasis study was a 'pathfinder' to establish safety and dosing, and expectations for the RA readout remain positive. CEO Paul Hudson added that the safety profile was a key finding and that there is significant external interest in combination therapies.