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Edward Tenthof

Managing Director and Senior Research Analyst at Piper Sandler

Edward Tenthoff is a Managing Director and Senior Research Analyst at Piper Sandler, specializing in drug discovery and biotechnology, with coverage spanning more than 70 healthcare and biotech companies such as Moderna, Alnylam Pharmaceuticals, and Arrowhead Pharmaceuticals. With over 1,400 published stock ratings and a consistent focus on the healthcare sector, his track record includes a price target met ratio of about 45%, though recent reports indicate a success rate near 28% and an average return per recommendation of -17.2%, with standout returns such as a 366% gain on Poseida Therapeutics. Tenthoff began his career as a medical technology analyst at Lehman Brothers, then covered genomics at Robertson Stephens & Company, before joining Piper Sandler in 2003. He holds a bachelor's degree from the University of Pennsylvania, has earned multiple sector awards including top stock picker accolades from the Wall Street Journal and Starmine, and is a registered securities professional with FINRA credentials.

Edward Tenthof's questions to ARROWHEAD PHARMACEUTICALS (ARWR) leadership

Question · Q4 2025

Edward Tenthof with Piper Sandler inquired about Arrowhead's upcoming data readouts for 2026, specifically asking for the first look from the ArrowDiamond PA program, other significant data sets beyond the obesity data in the first half, and an update on the ARO-RAGE program.

Answer

James Hamilton, Chief Medical Officer and Head of R&D for Arrowhead Pharmaceuticals, outlined key 2026 readouts including initial obesity data in early January and a larger dataset by Q2, ArrowDiamond PA data in summer, and ARO-MAPT data also in summer, looking for CSF tau levels. He also mentioned SHASTA III and IV readouts in Q3 2026, enabling an SNDA filing by year-end. For ARO-RAGE, he noted enticing knockdown data but a struggle for clinical benefit biomarkers, with a challenge study recently started, data not expected until late 2026.

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