Question · Q4 2025
Edward Tenthof with Piper Sandler inquired about Arrowhead's upcoming data readouts for 2026, specifically asking for the first look from the ArrowDiamond PA program, other significant data sets beyond the obesity data in the first half, and an update on the ARO-RAGE program.
Answer
James Hamilton, Chief Medical Officer and Head of R&D for Arrowhead Pharmaceuticals, outlined key 2026 readouts including initial obesity data in early January and a larger dataset by Q2, ArrowDiamond PA data in summer, and ARO-MAPT data also in summer, looking for CSF tau levels. He also mentioned SHASTA III and IV readouts in Q3 2026, enabling an SNDA filing by year-end. For ARO-RAGE, he noted enticing knockdown data but a struggle for clinical benefit biomarkers, with a challenge study recently started, data not expected until late 2026.