Question · Q4 2025
Tommy inquired about the factors assumed in Voxzogo's guidance, particularly regarding new patient starts and potential switching in the context of upcoming competition, and BioMarin's confidence in establishing BMN 333 as the preferred option.
Answer
Brian Mueller, Chief Financial Officer, explained that the 2026 Voxzogo guidance reflects scenarios including competitive impact and market access renegotiations, aiming for high single-digit growth. Cristin Hubbard, Chief Commercial Officer, reiterated the focus on driving new patient starts in the 0-2 age group and protecting against switching. Greg Friberg, Chief R&D Officer, expressed confidence that BMN 333's superior growth profile, powered to detect a 2.25 cm/year increase, will differentiate it as the most active agent.
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