Arrowhead Pharmaceuticals - Earnings Call - Q2 2016

Transcript

Speaker 0

Ladies and gentlemen, welcome to the Arrowhead Pharmaceuticals Fiscal twenty sixteen Second Quarter Financial Results Conference Call. Throughout today's call, recorded presentation all participants will be in a listen only mode. After the presentation, there will be an opportunity to ask questions. I will now hand the conference call over to Vincent Anzalone, Vice President of Investor Relations for Arrowhead. Please go ahead.

Speaker 1

Good afternoon, everyone. Thank you for joining us today to discuss Arrowhead's results from its fiscal twenty sixteen second quarter ended March 3136. With us today from management are President and CEO, Doctor. Christopher Anzalone, who will provide an overview of the quarter Doctor. Bruce Given, our Chief Operating Officer and Head of R and D, who will discuss our clinical programs and Ken Myszkowski, our Chief Financial Officer, who will give a review of the financials.

We will then open up the call to your questions. Before we begin, I would like to remind you that comments made during today's call may contain certain forward looking statements within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934. All statements other than statements of historical fact, including without limitation, those with respect to Arrowhead's goals, plans and strategies are forward looking statements. These include, but are not limited to statements regarding the anticipated safety and or efficacy of ARK-five twenty, ARK-five twenty one, ARK AAT, ARK F12, ARK LPA, ARK HIF2 and our other programs, as well as anticipated timing for study enrollment and completion and the potential for regulatory and commercial success. They represent management's current expectations and are inherently uncertain.

Thus, results may differ materially. Arrowhead undertakes no duty to update any of the forward looking statements discussed on today's call. You should refer to the discussions under Risk Factors in Arrowhead's annual report on Form 10 ks and the company's quarterly reports on Form 10 Q for additional matters to be considered in this regard. With that said, I'd like to turn the call over to Doctor. Christopher Anzalone, President and CEO of the company.

Chris?

Speaker 2

Thanks, Vince. Good afternoon, everyone, and thank you for joining us today. This is our first earnings call at Arrowhead Pharmaceuticals, and I wanted to take a moment to talk about our name change. While we remain a company rooted in research and world class science, our top priority is advancing products through clinical development to bring innovative new medicines to patients. The name Arrowhead Research was simply no longer an accurate representation of the company.

Arrowhead Pharmaceuticals reflects the progress we're making on our growing pipeline of RNAi based therapeutics. We have quickly become a company with multiple clinical stage products and we plan on having additional products enter clinical trials over the next year and beyond. This is an and move rather than an or. While we expand our focus to include clinical and eventually commercial development, we remain fiercely innovative and continue to drive big science. Our proprietary and constantly evolving technologies give us a robust and versatile drug discovery and development platform.

This allows us to continually build on successes from each program and develop effective new therapies rapidly, cost effectively and potentially with lower risk relative to traditional approaches. This is reflected in the speed at which we've gone from one clinical candidate to our current pipeline of six programs targeting a broad range of disease areas. It is also reflected in the confidence we have in ARK AAT and ARK-five twenty one for instance. We now know that ARK-five twenty does exactly what it was designed to do. It consistently and deeply reduces expression of HBV cccDNA.

We also know that it does this in a well tolerated manner. ARK-five twenty has been given to over 150 people and we continue to see a favorable safety profile. This high activity and emerging safety profile should read on ARC AAT and ARC-five twenty one because both use the exact same DPC delivery technology as ARC-five twenty. It is uncommon in the pharmaceutical industry to have this carryover safety and activity understanding as new drugs come into the clinic and this is a substantial value driver. We have made a great deal of progress across all of our programs as well as the underlying platforms during the fiscal twenty sixteen second quarter and the period since our last conference call.

I'll discuss a few of them now and provide some context. Later in the call, Bruce Given will give some more detail and provide a status update studies. I mentioned ARK-five twenty and let's talk a bit about that. During the quarter, we continued to execute quite well and there are now seven ARK-five twenty clinical studies actively enrolling patients. As a reminder, the following is a list of current studies.

1,002 is a single dose study in healthy volunteers testing faster infusion rates of ARK-five twenty. 2002 is a placebo controlled three month study of ARK-five twenty plus NUCs in NUC experienced E negative patients. 2003 is the same as 02/2002, but in E positive NUC experienced patients. 2007 is an open label, nine month extension for patients in 2002 and 2003 who achieve a one half log or greater reduction in circulating S antigen providing a full year of therapy for eligible patients. 2004 is our U.

S. Only placebo controlled three month study of ARK-five twenty plus NUCs in E positive patients. Two thousand and one extension is an open label study of one year of ARK-five twenty treatment on top of NUCs in patients from the single dose 2001 study. Fifty four of the fifty eight patients from 2001 are eligible to participate. Monarch is our open label study that includes arms with ARK520 alone and triple therapy with ARK520 plus NUCs plus interferon.

We intend to open additional arms as combinations with new compounds become available. These are a lot of studies and we will enroll a large number of patients. And given the diversity of disease factors, they will be required to gain a more complete understanding of ARK-five twenty and how it works. These studies will span various HBV genotypes, nuke experience and E antigen status. We go into these studies as clear intellectual leaders in HBV.

Between our long term study in chronically infected chimps and our ARK520 studies to date, we have moved HBV field forward and I expect to retain this leadership position this year and beyond. We clearly have a comprehensive clinical program. The data continue to indicate that ARK-five twenty is highly active against cccDNA derived mRNA transcripts and thus can reduce the production of HBV proteins. Keep in mind that the virus hijacks patients' hepatocytes to make only five proteins and pre genomic RNA. That is all this virus does and our data suggests that we silence every one of them.

Several and possibly all of these proteins are believed to contribute to immune suppression and therefore, chronicity of HBV infection as the body is unable to control the virus. Many believe that dramatically reducing both circulating and intrahepatic proteins make it increasingly difficult for the virus to continue to evade immune control. In theory, this mode of action should be a powerful tool against the virus. It is difficult to imagine that the virus could continue its normal life cycle while everything it is capable of making is silenced. And of course, we are testing that theory now.

In addition to what ARK-five twenty could do on its own, it could be a powerful backbone therapy that is complementary to other therapeutic mechanisms, and we are eager to interrogate this possibility with various agents in our monarch study. We continue to see ARK-five twenty as a key to enabling functional cures in patients with chronic HBV infection. As we've said previously, ARK-five twenty appears to be maximally active in patients with higher relative levels of HBV cccDNA versus HBV that has integrated into the host DNA. During the quarter, we presented additional data at the EASL International Liver Congress in e antigen positive treatment naive patients from Cohort seven of the 2,001 study. This patient group is predicted to have higher relative levels of cccDNA.

These data show how powerful ARK520 is against cccDNA derived transcripts and how deeply we can knock down HBV proteins. We saw a max knockdown of S antigen of almost two logs or 99% and a dramatic duration of effect. We had previously reported the former, but the latter represented new data. In this group of patients, S antigen was still reduced by eighty three percent two months after a single dose and seventy five percent after three months, which is the final time point of the study. In fact, one of the six patients demonstrated approximately one log or 90% reduction of circulating S antigen eighty five days after a single dose of ARK520.

These are important data because there has simply never been a reliable report that approaches this depth and duration, particularly after a single dose of a therapeutic. In addition, serum HBV DNA reductions of up to 5.5 logs were observed. These were exciting data for us and for the HBV community and give us great confidence in our ongoing multiple dose and combination studies. In addition to ARK-five twenty, we also recently announced that we filed for regulatory clearance to begin a Phase III study of ARK-five twenty one, our second pipeline candidate targeting chronic HBV. We think having both ARK-five twenty, which has been very active in patients with higher cccDNA and ARK-five twenty one, which may be optimal for those with lower cccDNA, should provide us with greater potential to treat all HBV patients.

We have an aggressive plan for the development of ARK-five twenty one that includes an accelerated first in man Phase onetwo design intended to allow rapid transition into a multi dose patient cohorts. Our plan was to file regulatory submissions toward the end of this quarter, so we are already a couple of months ahead of schedule. We will provide more details about the design when we initiate the study, so stay tuned. We have moved very fast with this program and we think ARK-five twenty one increases our leadership position in the HPV space in the race to a functional cure. Turning to ARC AAT, we continue to accrue our Phase one single ascending dose study that consists of Part A in healthy volunteers and Part B in patients with AATD.

We remain on schedule to complete enrollment and release top line results from both the expanded Part A and Part B this year and report full data at relevant medical meetings. We are currently preparing a pilot Phase 2a multiple dose study of ARK AAT that we intend to begin this year. During the quarter, we also presented new data on our three disclosed preclinical programs, ARKF12, ARKF2 and ARKLPA. These programs represent not only our expanding pipeline of RNAi therapeutics against a wide range of diseases, but also progress we're making on our underlying technology platforms. I will quickly go over these one by one.

First, ARKF12 is designed to inhibit the production of Factor XII. In an edema model in rats, ARKF12 led to a significant reduction in swelling. In animal models of thrombosis, ARKF12 was able to reduce the risk of blood clot formation without the undesirable bleeding risk caused by anticoagulants. These support our belief that ARKF12 has the potential to treat both hereditary angioedema, or HAE, and to prevent thrombosis. These are very different patient populations, and we have both subcutaneous and intravenous formats for this program.

So we are currently assessing what the best clinical path will be for this product. We plan on discussing this more in the future. RKIF2 is the first candidate to use a DPC vehicle designed for extrahepatic delivery. ARKHIF2 targets HIF2 alpha for the treatment of renal cell carcinoma. We present preclinical data showing proof of concept for the delivery vehicle and that ARKHIF2 could inhibit tumor growth and promote tumor cell death in multiple RCC mouse models.

This represents both an exciting new candidate and expansion of our DPC platform. Lastly, ARC LPA is the first RNAi therapeutic to use Arrowhead's new delivery vehicles designed for subcutaneous administration. This preclinical candidate is targeting lipoprotein A or Lp for the treatment of cardiovascular disease. High levels of Lp are associated with an increased risk of cardiovascular disease independent of cholesterol and LDL, and there's currently no good way to deeply reduce circulating levels of Lp. Data we recently presented show that ARC LPA can achieve up to 98% reduction of Lp in mice and 85% to 90% in primates with significant reductions through at least six weeks.

We think this is a very attractive candidate on its own and we are excited about our new subcutaneous platform that may create additional opportunities to address diseases that require chronic treatment and where the subcutaneous route may be preferable to patients and physicians. So as you've heard, this has been another highly productive quarter for us at Arrowhead. We are confident that novel medicines like the ones we're developing at Arrowhead that treat intractable diseases will in the end always have a great value. We are committed to pushing our pipeline forward and unlocking that value. With that overview, I would now like to turn the call over to Doctor.

Bruce Given, our COO and Head of R and D. Bruce?

Speaker 3

Thank you, Chris. Good afternoon, everyone. Before I review the status of our various clinical studies, I wanted to describe the ARK-five twenty data presented at EASL, the International Liver Conference that took place last month. We presented a poster on the full and final Cohort seven single dose results from the 2,001 study and a poster on new data from our groundbreaking chimpanzee study. In addition, our colleagues from the Victorian Infectious Diseases Reference Laboratory in Melbourne, Australia presented a poster on some of their leading edge analytical work from the first five cohorts of the 2,001 study.

Let me touch on some of the more intriguing findings. All three of these posters can be found on our website. First, regarding our HepARC2001 Cohort seven poster, ARK520 and entecavir produced very rapid HBV DNA suppression in hepatitis E antigen positive treatment naive patients. Achieving serum HBV DNA reductions of around four logs after only two weeks and up to 5.5 logs overall. All E antigen negative treatment naive patients achieved reductions that put them below the limit of quantitation with all but one achieving this by two weeks.

We have previously reported that ARK-five twenty showed moderate to strong synergism with both entecavir and tenofovir in mice. So we see this data is consistent with those findings. We suspect that synergism is seen because mechanistically ARK-five twenty would be expected to reduce levels of polymerase and pre genomic RNA. This leads us to believe the synergism could well be seen with other mechanisms and agents that would similarly benefit from reductions in viral antigens or pre genomic RNA. Capsid inhibitors and drugs targeting X antigen would be clear candidates for such a benefit.

The full three month data also showed that ARK-five twenty effectively inhibited HBV cccDNA derived mRNA with observed viral protein reductions in naive e antigen positive patients of up to two logs or ninety nine percent after a single dose. Chris mentioned this earlier, but I think it bears repeating. The duration of effect for S antigen reduction in the E antigen positive treatment naive patients is very intriguing. The mean reduction at the last study visit on day eighty five was still seventy five percent from baseline after a single dose of ARK-five twenty. There was also an interesting flattening of the rebound curve between days fifty seven and eighty five.

Mean E antigen and correlated antigen levels where measurable also were still reduced to day eighty five. As previously reported naive E negative patients had delayed mean S antigen response that didn't manifest until around three weeks post dose. The overall mean reduction was less in E negatives, but also had still not returned to the mean baseline by day eighty five. The academic community continues to recognize these data as important and the poster was again selected as a stopping point on the HBV expert tour and was featured in the What's New and Important General Lecture on HBV. We were also asked to present our data at recent NIH workshop dedicated to HBV.

In the poster in our chimpanzee study, we showed that after monthly administration of six to eleven doses of ARK-five twenty in chimpanzees chronically infected with HBV, the ARK-five twenty target site sequences remained virtually unchanged. This suggests us that no drug resistance developed during the treatment period. While we did not expect that mutation and resistance would be a problem, this gives us additional comfort as we conduct our multidose studies in HBV patients. We also showed additional biopsy data with deep sequencing of the HBV mRNAs after treatment with ARK-five twenty. These results demonstrated that all sequences containing the ARK-five 20 target sites were deeply knocked down in both E positive and E negative chimps.

This again supports our perspective that while surface antigen knockdown can be impacted by the relative amount of integrated derived surface antigen transcript, the other transcripts, which will be cccDNA derived, should be equivalently reduced in either E negative or E positive patients. As the field gets more interested in the pathologic roles of all hepatitis antigens, not just surface antigen, the unique ability of RNAi and ARK520 in particular to knock down all HBV viral transcripts takes an even greater significance. Finally from EASL, Doctor. Steven Lachernini has been studying patients at seroclear surface antigen. While rare, seroclearance does occur in a small minority of nuke treated patients.

Doctor. Lachernini has used a panel of monoclonal antibodies that bind specific parts of the surface antigen to look for changes in binding patterns as a way of studying the host immune response. He previously reported what he calls a clearance profile in patients as seroclearned on tenofovir based on changes in the monoclonal antibody binding. In the EASL poster from his group, he reported data from the four E negative NUC experienced cohorts and the first NUC experienced E positive cohort from our 2001 study. He showed that by week three around fifty percent of the ARK-five twenty treated patients were showing a clearance profile compared to zero placebo treated patients.

There was a corresponding trend in detection of immune complexes. We don't yet know the significance of these data on the ability of ARK-five twenty to achieve seroclearance, but the findings continue to intrigue the academic HBV community. I will now give a brief status update on some of our clinical studies. The 1,002 study is a single dose study to evaluate tolerability of increasing infusion rates of ARK-five twenty. We have also dosed five mg per kg and will be dosing six mg per kg at an infusion rate about twice as fast as we are currently using in our patient studies.

Continues to be well tolerated. And because of this we have added five and six mgs per kg single dose cohorts to the 2,001 study just to give us dosing flexibility should we decide it is helpful to the program. Because it's in the 2,001 study this will be in HBV patients. In the 2001 open label extension most patients who completed the 2,001 study are eligible to enroll if they wish. Those who elect to participate will receive up to thirteen doses once every four weeks.

This study has begun and some patients from cohort seven have already initiated dosing. 02/2003 are multiple dose studies in e antigen negative and positive patients respectively, both of which are recruiting patients on existing entecavir or tenofovir therapy. The 2,002 study is about two thirds enrolled and the 2,003 study is about half enrolled. We are still on schedule to complete enrollment for both studies this year. Patients in 2000 and '2 and two thousand and three that achieved greater than half log reduction in S antigen are eligible to roll over into 02/2007, which is a year long I'm sorry, which is a long term extension that allows patients to be dosed up to a year.

2007 has been initiated in Hong Kong and South Korea and patients have begun to be dosed. For the Monarch study in which most initial cohorts enjoy a triple I'm sorry, a triple combination with ARK-five twenty, entecavir and interferon, dosing began in January. We have enrolled patients in three different cohorts, but have not completed any of those three cohorts yet. The initial triple combination cohorts are planned to receive ARK520 every four weeks for forty eight weeks, daily entecavir for sixty weeks and pegylated interferon for forty eight weeks. We hope to look at other combinations as new therapies mature to the point that they can be included.

Ever since we learned of the importance of integrated DNA from our CHIP study, we have fast tracked our development program for ARK-five twenty one. As perhaps all of you are aware, ARK-five twenty one combines our best RNAi trigger from ARK-five twenty with our best trigger targeting integrated transcripts. As such, we believe it can be effective against all HBV derived RNA transcripts, whether from integrated or cccDNA. We set a breakthrough goal to submit an application for a Phase I study by the middle of this year and achieve submission in April. We feel that we understand the likely doses and safety profile of ARK-five twenty one based on everything we have learned from ARK-five twenty.

Because of this, we have proposed a trial design that moves quickly in the multiple doses in healthy volunteers and HBV patients. If this design is agreeable to IRBs and regulators, we should have a lot to report from this program in coming quarters. Moving on to ARK AAT, we've enrolled more than 50 subjects between Part A in healthy volunteers and Part B in patients in the single dose Phase I study. We intend to have both parts of the study fully enrolled before the end of the year. We are also applying to begin a pilot Phase IIa multiple dose study.

This study will look at the effect on circulating levels of AAT after multiple doses of ARCA AT. More importantly, we also intend to take biopsies to determine the effect at the hepatocyte level. We have had discussions with regulatory authorities and our goal is to have this study underway later this year, so stay tuned. Finally, with our corporate name change, we also created a new website at arrowheadpharma.com. The pipeline section of this website has descriptions of our active clinical trials and links to the respective clintrials.gov entries.

Please refer to that if you would like more information about the studies I have mentioned. So with that, I'd like to turn the call over to Ken Biszkowski, ARO's Head Chief Financial Officer. Ken?

Speaker 4

Thank you, Bruce, and good afternoon, everyone. As we reported today, our net loss for the three months ended March 3136 was $20,800,000 or $0.35 per share based on 59,800,000.0 weighted average shares outstanding. This compares with a net loss of $28,700,000 or $0.51 per share based on 55,700,000.0 weighted average shares outstanding for the three months ended March 3135. Total operating expenses for the three months ended March 3136 were $21,300,000 compared to $29,700,000 for the three months ended March 3135. The decrease in operating expenses compared to the year ago period are primarily due to a prior year non cash charge of $10,100,000 for acquired in process research and development costs, a component of the accounting related to the Novartis acquisition.

This was somewhat offset by higher general and administrative expenses of $2,100,000 during the current period, primarily to increased legal and patent costs. R and D costs declined by $1,600,000 due to lower drug manufacturing costs, but higher clinical trial costs as our ARK-five 20 manufacturing campaign was completed last year and this year we are incurring higher clinical trial costs related to the ARK-five 20 Phase 2b studies. Net cash used in operating activities during the second fiscal quarter was $14,700,000 compared to $16,400,000 in the prior year period, a decrease of $1,600,000 This was driven by lower R and D costs and the receipt of a refundable R and D tax credit from Australia, somewhat offset by higher G and A expenditures. Turning to our balance sheet. At March 3136, including our investments in fixed income securities, our cash and investments balance was $61,500,000 a decrease of $15,100,000 from December 3135.

Our common shares outstanding at March 3136 were $60,000,000 which increased from $59,600,000 at December 3135, primarily due to the issuance of shares from restricted stock vesting and the exercise of stock options. Also at March 3136, there were 15,652 shares of preferred stock outstanding. These preferred shares are convertible into 2,700,000.0 shares of common stock. Common shares outstanding including the conversion of our preferred shares would be 62,600,000.0. With that brief overview, I will now turn the call back to Chris.

Speaker 2

Thanks, Ken. As you've heard, our data continue to be good and we are hitting the operational goals in our clinical programs. As I mentioned earlier, we have two candidates in the clinic, one that is about to enter the clinic, three more that are not too far behind and some additional undisclosed programs that we are working on. This is a robust pipeline for a company of our size, which gives us a lot of opportunity to build value. It also is about the limit of what we can handle with our current resources, headcount and facilities.

Because of this, we are for the first time in a position where we can support and are actively looking for potential partners and collaborators to expand the reach of the assets and potentially be a source of capital. This type of strategic shift can take some time, but we think that our broad IP, advanced technologies and expertise from working in the field for more than a decade make us an extremely attractive partner. Looking ahead over the next twelve months and beyond, there are multiple events that could drive value for our shareholders. The ARK-five 20 Monarch study and the 2,001 extension are open label studies that may provide opportunities to share data ahead of study completion. In addition, the clinical plan for ARK-five twenty one is aggressive, but we feel responsible given our knowledge base.

If IRBs and regulators agree, we may provide a readout faster than some think. The AHRQ AAT Phase IIa is anticipated to begin later in the year, and the Phase I is planned to complete enrollment with the readout this year. Behind these programs are ARKF12, ARK HIF2 and ARK LPA, which are all progressing nicely and should provide additional opportunities to give updates on the candidates and their respective technology platforms. I would now like to open the call up to your questions. Operator?

Speaker 0

Thank And our first question comes from the line of Michael Yee with RBC Capital Markets. Your line is now open.

Speaker 5

Good afternoon. Congrats on the quarter and thanks for taking the question. This is on for Michael Yee from RBC Capital Markets. Two questions if I may please. So first since you addressed that you're actively talking with potential partners just wondering if we could get a little bit more clarity there.

What types of discussions have you had? If you're willing to disclose what are the gating factors involved in those discussions? Could you perhaps provide illustration of potential scenarios and your options? And I know you said it might take some time but do you have any sense of broad timing? Thank you.

Speaker 2

Thanks very much, Judy. You know what, there's not much we can say The reason that we bring it up is that as you point out and as we said in the prepared remarks, this is something that we are now a bit more focused on than we have in the past because we have built out this infrastructure, we've built up these capabilities that enable us to do this. And our pipeline, at least for the time being, feels pretty complete. And so we've got the ability to do this.

And I think we are an attractive partner because we can move quickly, because we've got I think pretty attractive IP, because we've got good data with ARC-five 20, anticipate good data in ARC-eighteen and ARC-five 21. For all these reasons, think that it makes sense for us to start reaching out to potential partners. Now having said all of that, we don't control the timing of any of this, of course. And so we'll just have to see how it plays out. But it is certainly our hope and intention to enter into some of these agreements going forward.

Speaker 5

Okay, thank you. And my follow-up question is, you told us that 2002 is about two thirds enrolled, 2003 seems to be on track for good enrollment as well. We heard previously that you expect some open label data by maybe late this year. Is there some more specific timing you could give us especially on the, you know, the other studies like 2002 and 2003 where enrollment's progressing. When should we be expecting readouts from that 2017?

Is that a good guess?

Speaker 3

Hi Judy, it's Bruce Given. It's always a little hard to estimate. Know, I mean, you know, the gating items here is you have to enroll your last patient. Your last patient then has to get their four doses and then have their follow-up after the fourth dose. And then you have to clean all the data and lock it because both 2002 and 2003 are double blinded studies.

So everything has to be perfect in the database before you can finally lock it, load in the codes and analyze the data. So it's a little hard to get too precise. I think we've been guiding that we thought it was likely to be 2017 readouts for 2002 and 02/2003. And that still feels like the most likely scenario. I certainly wouldn't expect it to go beyond 2017.

It's really just a matter of when how early in 2017 might those appear. And I just can't give you perfect guidance on that at this point.

Speaker 2

And as you mentioned, the 2001 extension and Monarch are open label. And so of course, we've got much more flexibility on how and when we could disclose some data there. That's really on a kind of a wait and see basis. People have asked us what will be the trigger point for talking about those data. And unfortunately, we have those criteria set in stone.

It's something that we address as we see those data. So I would just say stay tuned on those open label studies.

Speaker 6

Thank you.

Speaker 2

You're welcome.

Speaker 0

And our next question comes from the line of Eun Yang with Jefferies. Your line is now open.

Speaker 6

Thank you. The Study 1,002 varying infusion rates, I think you already mentioned that about two times faster than current infusion rate. So what's the current infusion rate?

Speaker 3

So the current infusion rate is 0.4 mL a minute, which depending on the dose, you know, if you're at the four mg per kg dose, most people, you know, their infusion rates will be somewhere, you know, around twenty some minutes. So we were curious as to whether faster rates are possible. So for instance, in this five mg and the six mg per kg dose group, we're using an infusion rate of 0.9. So a little bit faster than two times. And that's the infusion rate that we're planning to use in the 05/21 study for instance.

So it looks like we could probably have shorter infusion times than we've been using. That's at least our current interpretation of the data. And just it felt like something that we should go back and visit. But the 1002 study is in normal volunteers.

Speaker 6

Yes. Yes.

Speaker 3

Just to be clear about that.

Speaker 6

Okay. And then in the past you mentioned that you would anticipate announcing clinical collaborations for ALCO-five twenty this year. Can you give us kind of a status update?

Speaker 2

Sure. We're still hopeful that we can bring in collaborators to Monarch. I tell you, our gating function here is the lack of a huge number of these potential compounds to combine with ARK-five twenty. We see an awful lot of interest currently in the space. The vast majority of that interest is early stage, preclinical, early clinical programs.

And so it takes a little while to move those things to the clinic. So certainly 2017 and beyond, there'll be more to choose from. But we still think that 2016, will bring in at least one additional compound into a Monarch cohort in addition to of course what we're doing with interferon.

Speaker 6

Okay. And then in the past you also mentioned, I mean there are a lot of studies. But one study you mentioned was 02/2006. Is that still under plan? And if so, what's 2006 about?

Speaker 3

Yeah, so 2006 was a study that we were thinking about that was looking at very detailed immunologic measures, you know, such as T cell markers and, you know, T cell function and things of that sort. In the end, you know, that was one of the things that we decided to not do this year, largely as a way to just sort of control our capital usage during the year. We still plan on doing a study like that, But we did set that aside for this year.

Speaker 2

And I think the fact that we have all these studies going is really an important marker. It means a few things, at least a few things. One, it means that we are serious about this disease. We are going at this guns with ablazing trying to find this functional cure. But it also means that we're going about this, I think in a very mature way.

This is a very difficult virus as you know. There are a number of variables. It's not just e antigen status, it's not just nuke experience, it's also various genotypes. And we think the only way to really get a handle on how a drug works with this virus is to do this large number of studies. It's too bad because it's going to require a lot of people, but it's important to understand how this thing works.

And again, I think it's a reflection of our understanding of the virus and the maturation of this company as real clinical organization.

Speaker 6

Okay. Thank you.

Speaker 2

Sure.

Speaker 0

And our next question comes from the line of Benjamin Adler with Piper Jaffray. Your line is now open.

Speaker 7

Hi guys, thanks for taking the question. I wanted to maybe change gears a little bit and talk about ARKHIF2. I really like the approach, you know, going after HIF2 in renal cells. But as you know, it's an area which is evolving very rapidly. I kind of just wanted to get your thoughts on where the drug fits in when the dust starts settling.

You know, you have more advances in anti angiogenic, you have immuno oncology coming in. Do you see this ultimately going in as a combo? Do you see this still as a monotherapy? So I just sort of wanted to see how things are shaping up from your end.

Speaker 3

Yeah, I think that's really a great question. You know, renal cell carcinoma has been a bit of an outlier in cancer in that it's been receiving monotherapy, mostly because the drugs that have been available really didn't play well with each other. And when people tried to do combination therapy, you know, they were toxicity limited. You know, we've always thought that the best approach for HIF2 and basically the best approach in renal cell carcinoma would be to find new agents that could play well with others and, you know, that would allow combination combination therapy. Therapy.

So, you know, we've always envisioned, that we would hope, that, you know, we would find, you know, the ability to treat in combination. And the neat thing, of course, about RNAi is that we administer it, and then it has a durability, of a month or more with a single injection, for instance. So we're very hopeful that, you know, we will fit well into combination therapy, which generally in cancer, you know, that's how you really make the big strides when you're able to go combination. So we like the fact that there's a diversity of different drugs being developed in clear cell, renal cell carcinoma. And we are very hopeful that we will play well with others.

Speaker 2

And also, I think the way to look at that is twofold. One is as a candidate and we're excited about that as a candidate and we think that we will be treating this disease in a unique and we think powerful way. But the other way to look at this is as a platform. We view this ability to deliver to certain tumor cells as a franchise unto itself. Once we can validate that with RKF2 or anything else for that or others for that matter, we can use that for other targets for other cancer types.

And so we view that as really scalable and a program with real legs. And we're extremely excited about pushing that into the clinic at some point and really blowing that out into a business unto itself.

Speaker 7

Right, right. I see that. So then maybe just a quick follow-up and this is more long range thinking. So once you establish that you can target different extrahepatic tissues, in this case tumors, a lot of cancers obviously have more than one driving mutation or more than one driving pathway. Do you guys look at the potential or do you see the potential with your DPCs to deliver more than one trigger?

That something that Yes, you think is

Speaker 3

we do. And it's certainly feasible. I mean, that's basically we're doing it right

Speaker 2

now with ARC-five twenty. We have two triggers

Speaker 3

in ARC-five twenty.

Speaker 2

Also ARC-five twenty one.

Speaker 3

Yes, and five twenty one, you're

Speaker 7

right. Fair enough.

Speaker 3

So sure, it's feasible. And we think that's something that absolutely could be developed. I mean, HIF2 has been important for us in trying to work out extrahepatic delivery, which as you probably know in the field has been extremely difficult. About the only way people have been able to do it up till now is had tended to be with liposomes, which are very problematic delivery systems. So we're targeted delivery.

But once we've achieved the kind of profile that we want, I don't see any reason why we couldn't do multiple genes at the same time.

Speaker 7

Okay, great. Thanks guys.

Speaker 2

You're welcome.

Speaker 0

And I'm showing no further questions at this time. I would now like to turn the call back over to Mr. Chris Anzalone, CEO of Arrowhead for closing remarks.

Speaker 2

Thanks, everyone, for your interest, we look forward to speaking with you again next quarter or sooner.

Speaker 0

Ladies and gentlemen, thank you for participating in today's conference. This does conclude the program. You may all disconnect. Everyone have a good day.