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Felix Baker

Non‑Executive Chairman at BICYCLE THERAPEUTICS
Board

About Felix J. Baker, Ph.D.

Felix J. Baker, age 56, was appointed to the Bicycle Therapeutics plc (BCYC) Board on April 18, 2024 and is slated to become Non‑Executive Chairman immediately following the 2025 AGM . He is a Managing Member and co‑founder (with Julian Baker) of Baker Bros. Advisors LP, a biotechnology‑focused investment adviser formed in 2000 . He holds a B.S. and Ph.D. in Immunology from Stanford University and completed two years of medical school there . The Board has determined he is independent under Nasdaq rules; independent directors held two executive sessions in 2024 .

Past Roles

OrganizationRoleTenureCommittees/Impact
Seagen, Inc.DirectorJul 2003 – Dec 2023Not disclosed in BCYC proxy
Alexion Pharmaceuticals, Inc.DirectorJun 2015 – Feb 2021Not disclosed in BCYC proxy
Talis Biomedical CorporationDirectorJul 2013 – Mar 2023Not disclosed in BCYC proxy

External Roles

OrganizationRoleTenureNotes
Baker Bros. Advisors LPManaging MemberCo‑founded in 2000Biotechnology‑focused investment adviser
Kodiak Sciences, Inc.DirectorSince Sep 2015Public biotechnology company
Kiniksa Pharmaceuticals International, plcDirectorSince Oct 2015Public biopharmaceutical company
IGM Biosciences, Inc.DirectorSince Jan 2021Public biotechnology company
Kymera Therapeutics, Inc.DirectorSince Mar 2024Public biotechnology company

Board Governance

  • Classification: Class I director; current term ends at the 2026 AGM .
  • Committee assignment: Member, Nominating & Corporate Governance Committee (NCGC); chair is Jose‑Carlos Gutierrez‑Ramos .
  • Upcoming role: Will serve as Non‑Executive Chairman immediately following the 2025 AGM .
  • Independence: Board determined all directors other than Kevin Lee and Pierre Legault are independent; Baker is independent .
  • Engagement: Independent directors held two executive sessions in 2024; committee meetings in 2024—Audit (8), Compensation (7), NCGC (8) .
  • NCGC mandate: Includes assessing conflicts of interest for directors/officers and overseeing committee appointments and chair roles .
  • Compensation Committee interlocks: None identified in 2024 (no cross‑board executive interlocks) .
  • Non‑exec director terms: Letters allow termination on ≤3 months’ notice; Board is staggered Class I–III .

Fixed Compensation (Non‑Employee Director – FY2024)

ComponentAmount (USD)Notes
Fees earned or paid in cash$44,005Pro‑rated for appointment on Apr 18, 2024
Payment termsFees paid monthly; expenses reimbursed per policy
Annual cash retainer policyBase fee plus committee chair/membership fees; not performance‑related

Performance Compensation (Non‑Employee Director – FY2024)

Award TypeGrant DateSharesExercise Price (USD)ASC 718 Fair Value (USD)ExpirationVesting
Stock options18 Apr 202424,000$21.82$352,47218 Apr 20343 equal annual installments
RSUs (deferred settlement)18 Apr 202412,000$261,8403 equal annual installments; settlement deferred until separation, disability, death, or qualifying change‑in‑control (Treas. Reg. 1.409A)

Performance metrics table:

ItemStatus
Performance‑based conditionsNone; director awards are time‑based vesting only
Option repricingEIP permits repricing of underwater options, but no changes were made to exercise prices/vesting in 2024

Other Directorships & Interlocks

CompanyRoleStatus/Years
Kodiak Sciences, Inc.DirectorSince Sep 2015
Kiniksa Pharmaceuticals International, plcDirectorSince Oct 2015
IGM Biosciences, Inc.DirectorSince Jan 2021
Kymera Therapeutics, Inc.DirectorSince Mar 2024
Seagen, Inc.DirectorJul 2003 – Dec 2023
Alexion Pharmaceuticals, Inc.DirectorJun 2015 – Feb 2021
Talis Biomedical CorporationDirectorJul 2013 – Mar 2023

Notes: BCYC policy allows that fees for non‑executive directors appointed by an investor may be paid to that investor on behalf of the director (potential interlock/payment channel) .

Expertise & Qualifications

  • Biotech investment expertise as Managing Member of Baker Bros. Advisors LP; extensive service on boards of biotech/pharma companies .
  • Scientific credentials: B.S. and Ph.D. in Immunology from Stanford; completed two years of medical school .
  • Governance credentials: Designated as independent; will serve as Non‑Executive Chairman post‑AGM, signaling board leadership experience .

Equity Ownership

Data PointValue
Beneficially owned shares (as of Dec 31, 2024)30,323,301
Breakdown of beneficial holdings10,885,357 ADSs; 19,437,944 non‑voting ordinary shares held by connected persons (Funds)
Options outstanding (12/31/2024)24,000
RSUs outstanding (12/31/2024)12,000
5% shareholder position via Baker Bros. Advisors LP affiliated entities10,900,657 ADSs; 22.8% of total voting rights
Ownership guidelines (adopted Dec 2024)Non‑employee directors must own shares worth ≥3× annual cash retainer; options/unearned PSUs excluded; 5‑year compliance period
Compliance statusAll officers and directors in compliance as of Apr 14, 2025

Governance Assessment

  • Alignment: Very high ownership through Baker Bros. affiliated entities (22.8% voting ADSs; additional non‑voting ordinary shares) aligns interests with shareholders and provides significant influence .
  • Committee role: Member of NCGC overseeing conflict assessments and board effectiveness; independent status affirmed by Board .
  • Leadership transition: Becoming Non‑Executive Chairman post‑AGM enhances oversight but heightens scrutiny given simultaneous role as managing member of a 5%+ shareholder; Board affirms independence .
  • Pay structure: Director compensation is predominantly equity‑based with time‑based vesting and deferred RSU settlement; no performance‑based conditions—reduces pay‑for‑performance linkage for directors but aligns through ownership .
  • Policies: Company maintains clawback policy for executives and anti‑hedging/anti‑pledging practices; share ownership guidelines apply to directors and are met .
  • Plan risk: EIP permits unilateral option repricing (potential red flag), though no repricing or vesting changes occurred for directors in 2024 .
  • Shareholder sentiment: Strong say‑on‑pay support (96.8% in May 2024) indicates broad investor confidence in compensation governance .

RED FLAGS / WATCHPOINTS

  • Significant shareholder‑director duality: Managing Member of Baker Bros. Advisors LP while serving as Non‑Executive Chairman may create perceived influence/conflict—mitigated by Board’s independence determination and NCGC conflict oversight .
  • Option repricing authority under EIP: Although unused in 2024, the ability to reprice underwater options warrants monitoring for shareholder‑friendly application .
  • Investor‑appointed fee payment channel: Policy allows fees for certain investor‑appointed directors to be paid to investors, which could present optics/flow‑of‑funds considerations if applied; confirm recipient for Baker’s fees as needed .