Earnings summaries and quarterly performance for BICYCLE THERAPEUTICS.
Executive leadership at BICYCLE THERAPEUTICS.
Kevin Lee
Detailed
Chief Executive Officer
CEO
Alethia Young
Detailed
Chief Financial Officer
Alistair Milnes
Detailed
Chief Operating Officer
Eric Westin
Detailed
Chief Medical Officer
Jennifer Perry
Detailed
Chief Strategy Officer and Head of Commercial
Michael Hannay
Detailed
Chief Product and Supply Chain Officer
Michael Skynner
Detailed
Chief Technology Officer
Zafar Qadir
Detailed
Chief Legal Officer and General Counsel
Board of directors at BICYCLE THERAPEUTICS.
Research analysts covering BICYCLE THERAPEUTICS.
Recent press releases and 8-K filings for BCYC.
Bicycle Therapeutics Provides Pipeline and Financial Updates at Jefferies Conference
BCYC
Guidance Update
New Projects/Investments
- Bicycle Therapeutics updated the timeline for dose selection in the pivotal Phase II/III study for zelenectide pevedotin (DV-2) in bladder cancer, now expected in Q1 2026, a slight shift from Q4 2025, to allow for global regulatory feedback.
- The company reported a strong financial position with $648 million in cash as of September, providing a cash runway into Q1 2028.
- Significant updates for BT5528, targeting EphA2, are anticipated at a medical conference in H1 2026.
- Bicycle is also exploring zelenectide's potential in Nectin-4 amplified solid tumors like breast and lung cancer, with studies actively enrolling.
Nov 18, 2025, 10:30 AM
Bicycle Therapeutics Provides Updates on Zelenectide Pevedotin Development and Financial Position
BCYC
Guidance Update
New Projects/Investments
- Bicycle Therapeutics is advancing zelenectide pevedotin, a Nectin-4 targeted MMAE drug conjugate, in a seamless Phase 2/3 pivotal study for bladder cancer, with a dose selection update now expected in Q1 2026 to allow for global regulatory feedback.
- The company reported $648 million in cash as of September, providing a cash runway into Q1 2028.
- Beyond its lead program, Bicycle is developing BT5528 (targeting EphA2) with a significant update anticipated in H1 2026, and is also making significant efforts in radio conjugates.
- Zelenectide pevedotin is also being explored for Nectin-4 amplified tumors, a potential opportunity in breast and lung cancers, with studies actively enrolling.
Nov 18, 2025, 10:30 AM
Bicycle Therapeutics Updates on Zelenectide Pevedotin Development and Financial Position
BCYC
Product Launch
Guidance Update
New Projects/Investments
- Bicycle Therapeutics is advancing its lead molecule, zelenectide pevedotin, a Nectin-4 targeted MMAE drug conjugate, in a pivotal Phase 2/3 study (Duravelo-2) for bladder cancer, aiming for comparable efficacy with a differentiated safety profile compared to Padcev.
- The timeline for dose selection in the Duravelo-2 study for zelenectide pevedotin has been adjusted from Q4 2025 to Q1 2026 to ensure alignment with global regulatory bodies.
- The company reported $648 million in cash as of September, providing a cash runway into Q1 2028, which is sufficient to complete the Duravelo-2 study through Phase 3.
- Bicycle Therapeutics is also progressing BT5528, targeting EphA2, with a significant update expected in H1 2026, and exploring opportunities for zelenectide pevedotin in Nectin-4 amplified solid tumors and in radio conjugates.
Nov 18, 2025, 10:30 AM
Bicycle Therapeutics Reports Q3 2025 Financial Results and Business Progress
BCYC
Earnings
New Projects/Investments
Guidance Update
- Bicycle Therapeutics plc reported cash and cash equivalents of $648.3 million as of September 30, 2025, excluding a $38.2 million U.K. R&D tax credit received in October 2025, and anticipates a financial runway into 2028.
- The company expects to provide an update on dose selection for the Phase 2/3 Duravelo-2 pivotal trial and zelenectide pevedotin's potential approval pathway in metastatic urothelial cancer in the first quarter of 2026, following feedback from multiple regulatory agencies.
- For the three months ended September 30, 2025, the company reported a net loss of $59.1 million, or $(0.85) basic and diluted net loss per share.
| Metric | Q3 2024 | Q3 2025 |
|---|---|---|
| R&D Expenses ($USD Thousands) | $48,265 | $58,426 |
| G&A Expenses ($USD Thousands) | $18,257 | $18,859 |
| Net Loss ($USD Thousands) | $(50,802) | $(59,100) |
| Net Loss Per Share ($USD) | $(0.74) | $(0.85) |
Oct 30, 2025, 11:05 AM
Quarterly earnings call transcripts for BICYCLE THERAPEUTICS.
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