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    Gain Therapeutics Inc (GANX)

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    Gain Therapeutics, Inc. (GANX) is a biotechnology company specializing in the development of novel small molecule therapeutics to treat diseases caused by protein misfolding. The company leverages its proprietary Magellan™ drug discovery platform to identify allosteric binding sites on proteins, enabling the modulation of protein function to address underlying disease mechanisms. GANX focuses on therapeutic areas such as central nervous system disorders, lysosomal storage disorders, metabolic disorders, and oncology.

    1. Research and Development - Develops small molecule therapeutics targeting diseases caused by protein misfolding, utilizing the Magellan™ drug discovery platform to identify and modulate allosteric binding sites.
    2. Pipeline Programs - Includes GT-02287, a clinical-stage product candidate for Parkinson’s disease, aimed at restoring glucocerebrosidase function, reducing toxic lipid substrates, and improving mitochondrial health.
    NamePositionExternal RolesShort Bio

    Gene Mack

    ExecutiveBoard

    Chief Executive Officer

    Gene Mack has been serving as CEO of GANX since January 2025, after previously serving as CFO from April 8, 2024 and Interim CEO from June 25, 2024 to January 6, 2025.

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    Gianluca Fuggetta

    Executive

    Senior Vice President Finance and Principal Financial Officer

    Gianluca Fuggetta is the Senior Vice President Finance and Principal Financial Officer at GANX since January 6, 2025. He has progressed through various finance roles at GANX and previously built his career as an Assurance Manager at PwC.

    Claude Nicaise

    Board

    Member of the Board of Directors

    Board Member at Sarepta Therapeutics, Inc. since 2015; Board Member at Chemomab Therapeutics since 2021; Board Member at Cassava Biosciences since January 2024

    Claude Nicaise, M.D. has over 35 years of experience in clinical and regulatory affairs and has been serving as an independent board member at GANX since January 2021. He has held leadership roles at major companies including Alexion Pharmaceuticals and Bristol-Myers Squibb.

    Dov Goldstein

    Board

    Board Member

    Chief Financial Officer of BioAge Labs

    Dov Goldstein, M.D. serves as a Board Member and Audit Committee Chair at GANX since January 2021, leveraging his extensive background in science and financial management. He has over 20 years of experience and currently serves as the Chief Financial Officer of BioAge Labs, among other executive roles in the industry.

    Eric I. Richman

    Board

    Board Member

    Advisor at Broad Oak Capital; Director at Neubase Therapeutics, Inc.; Director at NovelStem International Corp; Director at LabConnect, Inc.; Co-founder and Chairman at InFuse Holdings

    Eric I. Richman has served as a Board Member at GANX since July 2020 after previously serving as CEO from June 2020 to September 2022, bringing over 30 years of experience in biotechnology and pharmaceuticals.

    Gwen Melincoff

    Board

    Member of the Board of Directors

    Managing Director at Gemini Advisors LLC; Advisor at Verge Genomics; Board Member at Protalix Biotherapeutics, Inc.; Board Member at Collegium Pharmaceutical, Inc.

    Gwen Melincoff has over 25 years of experience in business development and venture capital in the biotechnology and pharmaceutical industries, and she has served as a board member at GANX since January 2021. She also contributes her expertise externally as Managing Director at Gemini Advisors LLC, Advisor at Verge Genomics, and as a board member at Protalix Biotherapeutics, Inc. and Collegium Pharmaceutical, Inc..

    Hans Peter Hasler

    Board

    Member of the Board of Directors at GANX

    Chairman of the Board at HBM Healthcare Investments AG; Director of the Board at Minerva Neuroscience Inc.; Nonexecutive Chairman of the Board at Shield Therapeutics PLC; Chief Advisor at SBTech Advisory

    Hans Peter Hasler has been serving as a member of the Board of Directors at GANX since January 2021. He is an experienced leader in the biotechnology and pharmaceutical industries, having held positions such as Chairman of the Board at HBM Healthcare Investments AG and served as CEO at Vicarius Pharma AG until February 2020.

    Jeffrey Riley

    Board

    Board Member

    CEO and Director of Caravan Biologix, Inc. since September 2021; Executive Chairman of Blink TBI since August 2020

    Jeffrey Riley has served as a Board Member at GANX since May 2019, also taking on key governance roles as Chair of the Compensation Committee and Audit Committee Member. With over 25 years in the biotechnology and pharmaceutical industries, he strengthens strategic oversight at GANX while contributing to multiple organizations.

    Khalid Islam

    Board

    Founder and Chairman of the Board of Directors

    Chairman of the Board, Fennec Pharmaceuticals Inc.; Chairman of the Board, Minoryx Therapeutics S.L.

    Khalid Islam, Ph.D., is the co-founder and Chairman of the Board of Gain Therapeutics, Inc. since 2017. He brings over 35 years of biotechnology experience and has held leadership roles in several pharmaceutical companies.

    Matthias Alder

    Matthias Alder served as COO of GANX starting in October 2021 and was promoted to CEO and Board member on September 20, 2022, until his departure on June 25, 2024. He has over 25 years of experience in the pharmaceutical and biotechnology industries.

    Competitors mentioned in the company's latest 10K filing.

    CompanyDescription

    Vanqua Bio

    This company is targeting GBA-PD using small molecules, hypothesized to increase GCase levels, differing from the approach of acting as non-competitive pharmacological chaperones focused on stabilizing and restoring lysosomal function to misfolded GCase.

    BIAL

    This company is targeting GBA-PD using small molecules, hypothesized to increase GCase levels, differing from the approach of acting as non-competitive pharmacological chaperones focused on stabilizing and restoring lysosomal function to misfolded GCase.

    Caraway Therapeutics

    This company is targeting GBA-PD using small molecules, hypothesized to increase GCase levels, differing from the approach of acting as non-competitive pharmacological chaperones focused on stabilizing and restoring lysosomal function to misfolded GCase.

    Prevail Therapeutics

    This company is evaluating a potential gene therapy candidate in a Phase 1/2 clinical trial targeting GBA-PD through gene therapies.

    This company is targeting GBA-PD through gene therapies.

    CustomerRelationshipSegmentDetails

    Zentalis Pharmaceuticals

    Collaboration Agreement

    All

    Generated $0.055 million of revenue in 2023 (approximately 100% of total revenue). Collaboration ended 12/31/2023.

    No recent press releases or 8-K filings found for GANX.