- Opthea Limited (ASX/NASDAQ: OPT) has announced its intention to **voluntarily delist its American Depositary Shares (ADSs) from The Nasdaq Global Select Market**.  **[1815620_0001193125-25-257488_d35152d6k.htm:0]** **[1815620_0001193125-25-257488_d35152dex991.htm:0]** 
- This decision is due to the company no longer meeting Nasdaq's audit committee composition requirements and is part of a strategy to **streamline global operations, reduce expenditure, and improve capital efficiency** by consolidating its primary listing on the Australian Securities Exchange (ASX).  **[1815620_0001193125-25-257488_d35152dex991.htm:0]** 
- Opthea anticipates filing a Form 25 with the U.S. Securities and Exchange Commission (SEC) around **November 10, 2025**, with the **last day of trading of its ADSs on Nasdaq expected to be on or about November 19, 2025**.  **[1815620_0001193125-25-257488_d35152dex991.htm:0]** 
- The company's ordinary shares will **remain listed on the ASX**, which will be its primary trading market, though trading is currently suspended by the ASX.  **[1815620_0001193125-25-257488_d35152dex991.htm:0]** 
- Following the Nasdaq delisting, Opthea plans to maintain its American Depositary Receipt (ADR) program to facilitate continued holding and trading of its securities by U.S. investors through the U.S. Over-The-Counter (OTC) market.  **[1815620_0001193125-25-257488_d35152dex991.htm:0]**

Opthea (OPT)