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Cynthia Smith

Director at Protara Therapeutics
Board

About Cynthia Smith

Cynthia Smith (age 56) has served as an independent director of Protara Therapeutics (TARA) since January 2021. She is a biotechnology commercial executive with 20+ years of pharmaceutical industry experience, including senior roles at ZS Pharma (Chief Commercial Officer), Affymax (VP Market Access & Commercial Development), and Merck (Executive Director, Healthcare System & Medicare Strategy; crisis management for the Vioxx recall). She previously served in the White House Office of Management and Budget. Smith holds a BA (UNC Chapel Hill), an MS in public policy (Eagleton Institute, Rutgers), and an MBA (Wharton, UPenn) .

Past Roles

OrganizationRoleTenureCommittees/Impact
ZS Pharma, Inc.Chief Commercial OfficerJun 2013 – Dec 2016Led through IPO and acquisition by AstraZeneca
Affymax, Inc.VP, Market Access & Commercial DevelopmentOct 2008 – Mar 2013Commercial leadership in renal therapies
Merck & Co., Inc.Executive Director, Healthcare System & Medicare Strategy; prior leadership rolesJun 2000 – Oct 2008Corporate strategy, public policy, external affairs; global crisis management for Vioxx recall
White House OMBStaff (Clinton Administration)Not disclosedFederal policy experience

External Roles

OrganizationRolePublic/PrivateStart/End
Agios Pharmaceuticals, Inc.DirectorPublicSince Aug 2022
Spero Therapeutics, Inc.DirectorPublicNot disclosed
Akebia Therapeutics, Inc.DirectorPublicNot disclosed
Tvardi Therapeutics, Inc.DirectorPrivateNot disclosed
Dicerna Pharmaceuticals, Inc.Director (former)Public (acquired by Novo Nordisk)Served until Dec 2021 acquisition
French American FoundationBoard memberNon-profitNot disclosed

Board Governance

  • Independence: The Board affirmatively determined Smith is independent under Nasdaq rules; eight of nine directors (including Smith) are independent .
  • Board structure: Independent Chair (Luke Beshar); separation of chair and CEO roles to reinforce independent oversight .
  • Committee assignments (FY2024): Chair, Compensation Committee; not a member of Audit, Nominating & Corporate Governance, or Scientific Advisory committees .
  • Committee composition: Compensation Committee members are Barry Flannelly, Richard Levy, and Cynthia Smith (Chair); all are independent under Nasdaq Rule 5605(d)(2). Dr. Garceau served through the 2024→2025 compensation cycle and was then replaced by Dr. Levy .
  • Meetings/attendance (FY2024): Board met 7x; Compensation Committee 6x. Each director attended at least 75% of the aggregate meetings of the Board and their committees. Independent directors held 5 executive sessions in 2024 .
  • Nom/Gov process: Annual board/committee self-assessment (administered by counsel); independence and attendance considered in renomination decisions .

Attendance Snapshot (FY2024)

BodyMeetings HeldSmith Attendance
Board of Directors7≥75% of combined Board+committee meetings
Compensation Committee6≥75% of combined Board+committee meetings

Fixed Compensation

  • 2024 Non-Employee Director Compensation (actual):
    • Cash fees: $52,000
    • Equity grant-date fair value (options): $20,598
    • Total: $72,598
    • No stock awards (RSUs) in 2024 .
2024 Director CompensationAmount (USD)
Fees Earned or Paid in Cash$52,000
Option Awards (grant-date fair value)$20,598
Stock Awards (RSUs)
Total$72,598
  • Policy (effective April 1, 2025, cash elements): Annual cash retainer $40,000; additional committee member retainers: Audit $7,500, Compensation $6,000, Nominating & Corporate Governance $5,000, Scientific Advisory $25,000; chair retainers in lieu of member retainer: Audit Chair $15,000, Compensation Chair $12,000, Nominating Chair $9,000, Scientific Advisory Chair $50,000. Annual director compensation capped at $750,000 (or $1,000,000 in the first year of board service) based on accounting grant-date values .

Performance Compensation

  • Equity framework for non-employee directors (service-based; no disclosed performance metrics):
    • Initial option grant: 48,000 shares, vests 1/3 at 1-year anniversary then monthly over next 24 months.
    • Annual option grant: 24,000 shares, vests in full on the first anniversary of the grant date.
    • Change in control: All unvested director equity vests upon a “change in control” (single-trigger) .
  • 2024 equity awarded to Smith: Options with grant-date fair value of $20,598; no RSUs granted .

No performance metrics or targets are disclosed for director compensation; director equity vests based on continued service rather than performance outcomes .

Other Directorships & Interlocks

CompanySectorPotential Interlock/Conflict with TARA
Agios (public)BiopharmaNone disclosed by TARA
Spero (public)BiopharmaNone disclosed by TARA
Akebia (public)BiopharmaNone disclosed by TARA
Tvardi (private)BiopharmaNone disclosed by TARA
Dicerna (public; acquired)BiopharmaNone disclosed by TARA
  • Related-party and conflicts: The proxy discloses a Related Person Transaction Policy and enumerates transactions since Jan 1, 2024. No related-party transactions involving Smith are disclosed (transactions listed are executive employment/separation and standard director/officer indemnification agreements) .

Expertise & Qualifications

  • Commercial leadership across IPO/M&A contexts (ZS Pharma IPO and acquisition), market access, Medicare strategy, and crisis management (Vioxx) .
  • Policy and governance experience (OMB; multiple public company boards) .
  • Education: BA (UNC), MS Public Policy (Rutgers/Eagleton), MBA (Wharton) .
  • Board determined independent; committee chair experience (Compensation) .

Equity Ownership

  • Beneficial ownership (as of April 16, 2025): 61,750 shares beneficially owned via stock options exercisable within 60 days; percent of class: less than 1% .
  • RSUs: None vested-but-unsettled or unvested at 12/31/2024 for Smith (0) .
  • Outstanding director options (12/31/2024): 61,750 options for Smith .
Ownership DetailAmount
Beneficially Owned Shares (incl. options exercisable within 60 days)61,750; <1% of outstanding
RSUs vested but unsettled (as of 12/31/2024)0
Options outstanding (as of 12/31/2024)61,750
  • Hedging/pledging: Company policy prohibits short sales, options, hedging, and pledging/margining of company stock by directors; supports alignment with shareholders .

Governance Assessment

  • Strengths

    • Independence affirmed; board majority independent and independent chair enhances oversight .
    • Active role as Compensation Committee Chair; committee uses an independent compensation consultant and meets regularly in executive session; CEO excluded from decisions on his pay .
    • Attendance: At least 75% of combined Board/committee meetings; independent directors held 5 executive sessions, indicating robust independent oversight .
    • Clear related-party review policy; no Smith-related transactions disclosed .
    • Anti-hedging and anti-pledging policy reduces misalignment risk .
  • Watch items / potential investor considerations

    • Say-on-pay support was 72% in 2024, below many large-cap norms; the company reports outreach and added disclosure on performance goals—relevant given Smith’s role as Compensation Committee Chair .
    • Director equity accelerates upon a change in control (single-trigger), which some investors scrutinize; however, this is common for director awards and limited to service-based equity .
    • Multiple external board commitments (Agios, Spero, Akebia, Tvardi) increase time demands; the Nom/Gov committee reviews attendance and engagement during annual assessments and cited ≥75% attendance for all directors in 2024 .
  • Compensation mix context (2024): Approximately 72% cash ($52k) and 28% equity (options fair value $20.6k) for Smith, indicating meaningful but modest equity alignment versus cash retainers. Based on amounts in the 2024 non-employee director compensation table .

Committee Summary (FY2024)

CommitteeRoleIndependence & Process
CompensationChair (Smith); members: Flannelly, LevyAll members independent; charter authorizes independent advisors; regular executive sessions; CEO excluded from own pay deliberations
AuditNot a memberAudit chaired by Sargen; all members independent; financial expert designated (Sargen)
Nominating & Corporate GovernanceNot a memberOversees board refreshment, independence, annual self-assessments
Scientific AdvisoryNot a memberReviews R&D program risks

Director Fee Policy (Effective April 1, 2025)

ComponentAmount
Annual cash retainer (all directors)$40,000
Chair, Board (additional)$115,000
Committee member retainersAudit $7,500; Compensation $6,000; Nominating $5,000; Scientific Advisory $25,000
Committee chair retainers (in lieu of member retainer)Audit $15,000; Compensation $12,000; Nominating $9,000; Scientific Advisory $50,000
Initial option grant (new directors)48,000; vests 1/3 at 1 year, then monthly over 24 months
Annual option grant24,000; vests in full at 1 year
Change in controlSingle-trigger full vesting of unvested director equity
Annual cap≤$750,000 (≤$1,000,000 in first year) based on grant-date accounting value