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Jason Ryan

Chairman of the Board at GeneDx Holdings
Board

About Jason Ryan

Jason Ryan, age 50 as of April 15, 2025, is a Class II director at GeneDx (WGS), serving on the Board since July 2021 and currently as Chairman; he previously served as Executive Chairman from January 2022 to February 23, 2024 . He was CFO of Foundation Medicine (2015–2018) after senior finance roles there, and COO/CFO at Magenta Therapeutics (2019–2020); earlier finance leadership roles include Taligen Therapeutics, Codon Devices, and Genomics Collaborative, and he began his career at Deloitte . Ryan holds an MBA from Babson College, a BS in economics from Bates College, and is a CPA (Massachusetts) .

Past Roles

OrganizationRoleTenureCommittees/Impact
Foundation Medicine, Inc.CFO; prior SVP Finance and other finance rolesCFO: Mar 2015–Nov 2018Finance leadership; acquisition by Roche context
Magenta Therapeutics, Inc.COO & CFOJan 2019–Nov 2020Operations/finance oversight
Taligen Therapeutics; Codon Devices; Genomics CollaborativeFinance/strategic planning leaderNot disclosedFinance leadership in life sciences
Deloitte & Touche LLPEarly careerNot disclosedAudit/CPA foundation

External Roles

OrganizationRoleTenureCommittees/Impact
Singular Genomics Systems, Inc.DirectorApr 2021–Feb 2025Not disclosed
SomaLogic, Inc.DirectorMar 2023–Jan 2024Not disclosed
ArcherDX, Inc.DirectorApr 2020–Oct 2020Not disclosed

Board Governance

  • Board leadership: GeneDx separates the Chairman and CEO roles; Ryan serves as non-executive Chairman, presides over Board meetings, and acts as liaison among directors .
  • Committee assignments: The Board maintains Audit, Compensation, and Nominating & Corporate Governance committees; Ryan is not listed as a member or chair of these committees in the 2025 proxy’s committee roster .
  • Independence: The Board determined that all current directors except CEO Katherine Stueland and Jason Ryan are independent under Nasdaq rules; Ryan is therefore a non-independent director .
  • Attendance: In 2024 the Board met 6 times; Audit met 4; Compensation met 5 (plus 1 unanimous written consent); Nominating met 4. Each director attended at least 75% of meetings of the Board and of committees on which they served .
  • Annual meeting attendance: In fiscal 2024, one director attended the prior year’s annual meeting; attendance is encouraged but not mandated .
  • Risk oversight: Audit oversees financial controls and disclosure; Compensation oversees compensation-related risks; Nominating oversees governance and Board membership risks .

Fixed Compensation

Component20242025 Policy (adopted Apr 10, 2025)
Annual cash retainer – non-employee directors$40,000 $50,000
Additional retainer – non-executive Chairman (Ryan)$40,000 $50,000
Committee retainers – Audit (member/chair)$10,000 / $20,000 $10,000 / $20,000
Committee retainers – Compensation (member/chair)$7,500 / $15,000 $7,500 / $15,000
Committee retainers – Nominating (member/chair)$5,000 / $10,000 $5,000 / $10,000
Annual director comp capNot explicitly stated (2024)$750,000; $1,000,000 in initial year
  • 2024 cash fees for Ryan: $80,000 (comprised of $40,000 director retainer + $40,000 Chairman retainer) .

Performance Compensation

InstrumentGrant DateShares/ValueVestingNotes
Annual RSUs (directors)2024 (awarded during year)12,924 RSUs; $338,480 fair value Vests on earlier of first anniversary or next annual meeting Time-based; no performance metrics
Annual RSUs (directors)2025 Policy$240,000 grant-date value Same vest condition Time-based; no performance metrics
Initial RSUs (new directors)2024 Policy$400,000 3-year vest Time-based
Initial RSUs (new directors)2025 Policy$420,000 3-year vest Time-based

Performance metrics table (directors):

MetricApplicabilityTerms
Performance-based equity metrics (e.g., TSR, revenue, EBITDA)Not applicable to director RSUsDirector RSUs are time-based only; no performance conditions

Option awards (legacy board grants):

Grant DateSharesExercise PriceExpirationVesting
10/15/2021675$257.0710/15/2031Vested at next annual meeting or first anniversary
10/15/2021675$257.0710/15/2031Vested in equal monthly installments over 3 years
1/18/202213,022$113.851/18/2032Fully vested on 12/31/2022

Other Directorships & Interlocks

CompanySectorRoleTenure
Singular Genomics Systems, Inc.Life sciences toolsDirectorApr 2021–Feb 2025
SomaLogic, Inc.Proteomics/biotechDirectorMar 2023–Jan 2024
ArcherDX, Inc.Molecular diagnosticsDirectorApr 2020–Oct 2020

Expertise & Qualifications

  • Finance/biopharma leadership: CFO of Foundation Medicine; COO/CFO of Magenta; finance leadership at multiple life science firms .
  • Education/credentials: MBA (Babson), BS Economics (Bates), CPA (Massachusetts) .
  • Board experience: Multiple public/private life sciences boards; current GeneDx Chairman .

Equity Ownership

HolderShares Beneficially Owned% OutstandingBreakdown
Jason Ryan155,858<1%130 shares directly; 14,372 vested/exercisable options within 60 days; 141,356 shares held by a grantor retained annuity trust where Ryan is trustee and beneficiary
Unvested RSUs held (12/31/2024)12,924N/AAs disclosed in director awards table
  • Stock ownership guidelines: Adopted April 10, 2025; non-employee directors expected to hold 300% of their annual cash director retainer within five years. Counted toward guidelines: direct/beneficially owned shares and unvested time-based RSUs; options and performance-based equity do not count .
  • Hedging/pledging: Company policy prohibits hedging transactions, short sales, options on company securities, and pledging GeneDx stock as collateral .

Governance Assessment

  • Strengths

    • Separation of Chairman and CEO roles with clear responsibilities for Board leadership and management oversight .
    • Active committee structure with independent members; Compensation Committee uses independent consultant Aon, which the Board evaluated and deemed independent with no conflicts in 2024 .
    • Stock ownership guidelines enhance director alignment (300% of cash retainer over five years); inclusion of time-based RSUs supports accumulation .
    • Meeting cadence and attendance: Board and committees met regularly in 2024; all directors met the ≥75% attendance threshold .
  • Watch items / RED FLAGS

    • Independence: Ryan is a non-independent director (formerly an executive officer) while serving as Chairman; investors may scrutinize Board independence and checks/balances .
    • Shareholder litigation environment: Multiple law firms announced investigations following a short-seller report in Feb 2025, elevating governance and oversight risk signals for the Board’s controls and supervision .
    • Annual meeting engagement: Only one director attended the annual meeting the prior year; while policy encourages attendance, low attendance may be viewed negatively by some governance-focused investors .

Notes on Committee Assignments for Jason Ryan

CommitteeMembershipChair Role
Audit CommitteeNot listed as member No
Compensation CommitteeNot listed as member No
Nominating & Corporate Governance CommitteeNot listed as member No
Board ChairmanChairmanPresides and liaison

Director Compensation (2024 Actuals)

ComponentAmount
Fees Earned or Paid in Cash$80,000
Restricted Stock and Other Securities (RSUs)$338,480
Option Awards$0
Total$418,480

Employment & Contract History (GeneDx)

  • Ryan’s prior employment agreement (as Executive Chairman) expired December 31, 2023; it provided an annual base salary and 100% target bonus, and specified 50% employment time commitment .
  • Effective February 23, 2024, he resigned his officer role; he continues as Chairman and is compensated under the non-employee director policy .

Shareholder Voting Context (2025 Annual Meeting)

ProposalOutcome
Class I Director Election: Eli D. Casdin16,013,641 For; 6,823,343 Withheld; 2,682,501 broker non-votes
Class I Director Election: Joshua Ruch17,211,360 For; 5,625,624 Withheld; 2,682,501 broker non-votes
Auditor Ratification (Ernst & Young LLP)25,459,253 For; 49,423 Against; 10,809 Abstentions

Implication: Board nominees received majority support; robust auditor ratification may indicate baseline shareholder confidence in financial oversight .

Summary Implications for Investors

  • Alignment: Time-based RSU grants and stock ownership guidelines promote ownership, though absence of performance-linked director equity may limit direct pay-for-performance signals .
  • Governance quality: Structured committee oversight and use of an independent comp consultant are positives; attendance thresholds met .
  • Independence and litigation backdrop: Non-independent Chairman status and ongoing litigation/investigation headlines warrant monitoring of Board oversight rigor, internal controls, and disclosure practices .