Opaleye Management Inc.
Opaleye Management Inc. is a Boston-based hedge fund and investment advisory firm founded in 2013. The firm manages over $490 million in assets as of June 2025, with a primary focus on actively investing in publicly traded equity securities, particularly in the healthcare and life sciences sector. Opaleye is led by professional investors and serves institutional and high-net-worth clients.
Investment Strategy
Opaleye Management Inc. primarily focuses on investing in publicly traded equities, with a substantial portfolio concentration in biotechnology, pharmaceuticals, and healthcare companies. The firm is known for its research-driven, active management approach, building concentrated positions based on fundamental analysis and sector expertise. Opaleye frequently adjusts its portfolio based on changing company prospects and market opportunities, with a deep emphasis on high-growth life sciences companies.
Top Holdings
Equity Positions (38)
| Ticker | Security | Weight | Market Value | Shares | Avg Cost | Price | Change (QoQ) |
|---|---|---|---|---|---|---|---|
H HROW | HARROW HEALTH INC | 24.13% | $119.3M | 3,905,000 | $7.12 | $30.54 | +$14.1M |
E ETON | ETON PHARMACEUTICALS INC | 8.25% | $40.8M | 2,860,000 | $5.51 | $14.25 | +$3.7M |
I IMNM | IMMUNOME INC | 6.64% | $32.8M | 3,529,581 | $9.61 | $9.30 | +$8.9M |
S SNWV | SANUWAVE HEALTH INC | 6.52% | $32.2M | 980,000 | $35.35 | $32.86 | -$2.2M |
L LQDA | LIQUIDIA CORPORATION | 6.24% | $30.8M | 2,475,000 | $10.68 | $12.46 | -$2.5M |