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Ra Capital Management, L.P.

CIK:0001346824
Hedge Fund
$6B AUM
63 holdings
Boston, MA, United States
Founded:2001
100 employees
Latest filing:Jun 30, 2025

RA Capital Management, L.P. is a Boston-based investment firm founded in 2001, specializing in public and private investments in the biotechnology and life sciences sectors. The firm is led by Peter Kolchinsky and Rajeev Shah, and manages significant assets with a focus on innovative healthcare companies. It serves institutional investors and invests across venture capital and public equities strategies, with a dedicated team of over 51-200 employees. RA Capital's expertise centers on supporting transformative science and high-impact healthcare solutions.

Investment Strategy

RA Capital Management pursues a fundamentally driven investment strategy by investing in companies developing groundbreaking solutions in biotechnology, pharmaceuticals, and healthcare. The firm invests across both private and public markets, often supporting companies through multiple stages of their development. Its approach includes deep scientific diligence, a focus on transformative therapeutic areas, and long-term partnership with innovative companies aiming to address unmet medical needs.

Top Buys
A
ASNDASCENDIS PHARMA A/S - ADR
+$172.1M
C
CDTXCIDARA THERAPEUTICS INC
+$140.4M
S
SIONSIONNA THERAPEUTICS INC
+$72.0M
S
SPRYARS PHARMACEUTICALS INC
+$52.9M
E
ETNB89BIO INC
+$50.7M
Top Sells
P
PCVXVAXCYTE INC
-$71.2M
E
EWTXEDGEWISE THERAPEUTICS INC
-$66.2M
A
APGEAPOGEE THERAPEUTICS INC
-$58.6M
Z
ZLABZAI LAB LTD-ADR
-$46.8M
R
RXSTRXSIGHT INC
-$46.4M

Top Holdings

A
ASNDASCENDIS PHARMA A/S - ADR
+29.9%$1.77B
P
PCVXVAXCYTE INC
+6.6%$389.0M
R
RYTMRHYTHM PHARMACEUTICALS INC
+5.9%$351.4M
J
JANXJANUX THERAPEUTICS INC
+4.4%$258.5M
R
RNAAVIDITY BIOSCIENCES INC
+3.5%$206.4M

Equity Positions (61)

TickerSecurityWeightMarket ValueSharesAvg CostPriceChange (QoQ)
A
ASND
ASCENDIS PHARMA A/S - ADR29.90%$1.77B10,281,496$82.86$172.60+$172.1M
P
PCVX
VAXCYTE INC6.55%$389.0M11,965,991$40.28$32.51-$71.2M
R
RYTM
RHYTHM PHARMACEUTICALS INC5.92%$351.4M5,561,359$26.73$63.19+$29.1M
J
JANX
JANUX THERAPEUTICS INC4.35%$258.5M11,189,693$27.51$23.10-$43.6M
R
RNA
AVIDITY BIOSCIENCES INC3.48%$206.4M7,266,031$31.37$28.40+$20.4M

Industry Allocation

PHARMACEUTICAL PREPARATIONS
+77.9%
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
+19.6%
BLANK CHECKS
+1.5%
OPHTHALMIC GOODS
+0.8%
SERVICES-COMPUTER PROCESSING & DATA PREPARATION
+0.3%