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About
Jake Simson, Ph.D., is a Partner at RA Capital Management, L.P., based in Cambridge, MA. In his current role, he focuses on both public and private investments within the healthcare and life sciences sectors, and represents RA Capital on the Boards of companies such as Xenikos, Tyra Biosciences, AavantiBio, and DiCE Molecules.
Simson's expertise is centered on biotech and pharmaceutical innovation, with a particular emphasis on oncology, solid tumor therapeutics, and clinically translatable technologies for tissue repair. Over his tenure at RA Capital, he has advanced from Analyst and Principal to Partner, demonstrating broad experience across venture and growth-stage company leadership and investment analysis.
He holds a B.S. in materials science and engineering from the Massachusetts Institute of Technology and a Ph.D. in biomedical engineering from Johns Hopkins University, where his doctoral research focused on injectable hydrogels for musculoskeletal tissue repair. Simson is recognized for his evidence-based approach to investing and his active participation in shaping strategy as a board member for several high-growth therapeutics companies.
Career History
| Organization | Role | Date Range | Details |
|---|---|---|---|
| RA Capital Management, L.P. | Partner | Nov 2020 to Present | — |
| RA Capital Management, LLC | Principal | Nov 2017 to Nov 2020 | — |
| RA Capital Management, LLC | Analyst | May 2015 to Nov 2017 | — |
| RA Capital Management, LLC | Associate | Jun 2013 to May 2015 | — |
| Johns Hopkins University Translational Tissue Engineering Center | PhD Candidate | Jul 2008 to May 2013 | — |
| Pfizer | Collaborating Researcher | Jan 2010 to Nov 2010 | — |
| TiGenix | Visiting Research Associate | Jan 2009 to Feb 2009 | — |
| Tissue Engineering Laboratories | Undergraduate Research Associate | Dec 2006 to May 2008 | - Identified and analyzed the distribution of lubricin in samples of human intervertebral disc using immunohistochemistry techniques to determine the source and role of this protein in disc function
... |
Education
The Johns Hopkins University
2008 — 2013
Massachusetts Institute of Technology
2004 — 2008
Skills & Expertise
Others at Ra Capital Management, L.P. (41)
| Name | Role | Location |
|---|---|---|
 | Associate | Boston, MA , United States |
A Alexander Becker | Senior Associate | Boston, MA , United States |
 | Associate | Cambridge, MA , United States |
 | Associate | Boston, MA , United States |
 | Principal | New York, NY , United States |
| Associate | Boston, MA , United States | |
B Brian L | Analyst | Boston, MA , United States |
 | Principal | San Francisco, CA , United States |
D David Migl | Analyst | United States |
F Fuad Naser | Analyst | Boston, MA , United States |
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| Name | Role | Fund | Location |
|---|---|---|---|
J John Brennan | Principal | Sirios Capital Management L P | Boston, MA , United States |
K Kristin Foley | Head of Trading | Sirios Capital Management L P | Boston, MA , United States |
