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Sarissa Capital Management LP

CIK:0001577524
Hedge Fund
$559M AUM
7 holdings
Greenwich, CT, United States
Founded:2012
10 employees
Latest filing:Jun 30, 2025

Sarissa Capital Management LP is a hedge fund headquartered in Greenwich, Connecticut, United States. Founded in 2012 by Alex Denner, Sarissa specializes in healthcare and biotechnology investments, employing a team of approximately 10 professionals. The firm is known for its activist approach and focuses on delivering value to institutional and sophisticated investors through deep sector expertise and strategic engagement.

Investment Strategy

Sarissa Capital Management LP primarily targets healthcare and biotechnology companies, leveraging activist investment strategies. The firm seeks undervalued opportunities where it can engage with management and drive strategic or operational improvements. Its investment process is grounded in fundamental research and value creation through active governance initiatives, seeking to maximize shareholder returns in select life sciences sectors.

Top Buys
A
AMRNAMARIN CORP PLC
+$20.2M
I
IRWDIRONWOOD PHARMACEUTICALS INC
-$12.7M
I
INVAINNOVIVA INC
+$5.5M
C
CYTKCYTOKINETICS INC
-$4.7M
N
NBIXNEUROCRINE BIOSCIENCES INC
+$3.9M
Top Sells
A
AMRNAMARIN CORP PLC
+$20.2M
I
IRWDIRONWOOD PHARMACEUTICALS INC
-$12.7M
A
AMRNAMARIN CORP PLC
-$11.1M
I
INVAINNOVIVA INC
+$5.5M
C
CYTKCYTOKINETICS INC
-$4.7M

Top Holdings

I
INVAINNOVIVA INC
+36.6%$56.6M
N
NBIXNEUROCRINE BIOSCIENCES INC
+24.7%$38.1M
A
AMRNAMARIN CORP PLC
+13.1%$20.2M
C
CYTKCYTOKINETICS INC
+12.6%$19.4M
I
IRWDIRONWOOD PHARMACEUTICALS INC
+7.4%$11.4M

Equity Positions (7)

TickerSecurityWeightMarket ValueSharesAvg CostPriceChange (QoQ)
I
INVA
INNOVIVA INC36.64%$56.6M2,816,022$12.87$20.09+$5.5M
N
NBIX
NEUROCRINE BIOSCIENCES INC24.68%$38.1M303,151$112.85$125.69+$3.9M
A
AMRN
AMARIN CORP PLC13.05%$20.2M1,242,527$16.22$16.22+$20.2M
C
CYTK
CYTOKINETICS INC12.59%$19.4M588,357$59.65$33.04-$4.7M
I
IRWD
IRONWOOD PHARMACEUTICALS INC7.40%$11.4M15,919,435$11.97$0.72-$12.7M

Industry Allocation

PHARMACEUTICAL PREPARATIONS
+69.7%
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
+25.2%
IN VITRO & IN VIVO DIAGNOSTIC SUBSTANCES
+5.1%

Investment Team (2)

NameRoleLocationLinkedIn
M
Mark DiPaolo
Senior PartnerGreenwich, CT , United States
Patrice Bonfiglio
Patrice Bonfiglio
PresidentStamford, CT , United States