Jeff Meacham's questions to Acumen Pharmaceuticals (ABOS) leadership • Q2 2025
Question
An analyst on behalf of Jeff Meacham inquired about physician feedback on the use of pTau217 blood testing during the screening process for Alzheimer's patients.
Answer
Chief Medical Officer Dr. Eric Siemers stated that using pTau217 testing in the ALPITUDE study was highly effective, reducing the PET scan screen failure rate from over 60% to 17% and cutting screening costs by approximately 40%. He reported positive feedback from clinicians, noting that the FDA-approved test is expanding the diagnostic pipeline, with adoption seen even among primary care physicians.