Question · Q3 2025
Katherine asked for more color on why Sunitinib was chosen as the control arm for the Stellar-304 study in non-clear cell renal cell carcinoma (nccRCC), considering the various histologic subtypes in this population.
Answer
Dana Aftab, EVP of Research and Development, explained that Sunitinib is a highly relevant standard of care in this setting, used extensively both ex-US and in the US, and has an overlap in target profile with Zanzalintinib, making it a suitable comparator for a pivotal Phase 3 trial.
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