Question · Q3 2025
Simon P. Baker asked about the magnitude of Dupixent's gross margin improvement from manufacturing efficiencies in Q3. He also inquired about the potential for rosibutinib in Graves' disease and Sanofi's current interest in CMV vaccination following recent industry news.
Answer
CFO François-Xavier Roger clarified that Dupixent's C3 manufacturing had a very limited impact on Q3 gross margin, with the overall gross margin increase driven by volume growth, product mix (Ayvakit being more significant), and industrial restructuring. Head of R&D Houman Ashrafian expressed optimism for rosibutinib in Graves' disease, citing its autoimmune nature and success in other disorders. Head of Vaccines Thomas Triomphe acknowledged the recent CMV news but stated Sanofi had discontinued its own CMV program decades ago due to efficacy concerns, despite recognizing the need for a vaccine.