Palo Alto Investors LP
Palo Alto Investors LP is an independent hedge fund management firm headquartered in Palo Alto, California, United States. The firm primarily focuses on managing investment portfolios for high-net-worth individuals and institutional investors. Known for its specialization in public equities, particularly in the healthcare and biotechnology sectors, Palo Alto Investors LP was founded in 1989 and typically maintains a lean team structure. The firm leverages its deep fundamental research expertise to serve its sophisticated client base.
Investment Strategy
Palo Alto Investors LP utilizes a fundamental, research-driven approach focused largely on small- and mid-capitalization public equities, with a particular emphasis on the healthcare, biotech, and life sciences sectors. The firm is known for in-depth company analysis, long-term holding strategies, and identifying undervalued growth opportunities in its niche sectors. Their investment decisions are grounded in intensive due diligence, relying on both financial analysis and industry expertise to create concentrated portfolios.
Latest 13F Filing Activity
Palo Alto Investors LP filed their most recent 13F report on Jun 30, 2025 disclosing 45 equity positions with a total 13F market value of $470M. The fund increased holdings in Insmed Inc., Acadia Pharmaceuticals Inc., Disc Medicine Inc. among other positions. Palo Alto Investors LP reduced exposure to Amicus Therapeutics Inc., Biomarin Pharmaceutical Inc., Sarepta Therapeutics Inc. among others.
Top Holdings
Equity Positions (45)
| Ticker | Security | Weight | Market Value | Shares | Avg Cost | Price | Change (QoQ) |
|---|---|---|---|---|---|---|---|
I INSM | INSMED INC | 18.52% | $87.1M | 865,113 | $17.74 | $100.64 | +$11.8M |
A ACAD | ACADIA PHARMACEUTICALS INC | 11.76% | $55.3M | 2,563,209 | $27.63 | $21.57 | +$11.0M |
B BMRN | BIOMARIN PHARMACEUTICAL INC | 9.83% | $46.2M | 840,470 | $77.60 | $54.97 | -$23.9M |
F FOLD | AMICUS THERAPEUTICS INC | 6.84% | $32.1M | 5,610,513 | $9.22 | $5.73 | -$27.8M |
U UTHR | UNITED THERAPEUTICS CORP | 5.84% | $27.4M | 95,482 | $82.82 | $287.35 | -$5.0M |