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Arch Venture Management, LLC

CIK:0001274403
Venture Capital
$80M AUM
11 holdings
Chicago, IL, United States
Founded:1986
75 employees
Latest filing:Jun 30, 2025

ARCH Venture Management, LLC, headquartered in Chicago, Illinois, is a venture capital firm specializing in seed and early-stage investments in technology-based firms, particularly in information technology, life sciences, and physical sciences. The firm serves entrepreneurs and startups, providing capital, expertise, and support for commercialization. ARCH was founded in 1986 and is part of ARCH Venture Partners, employing a team of professionals with backgrounds in science, technology, and business. It is recognized as one of the leading early-stage venture investors in the United States.

Investment Strategy

ARCH Venture Management focuses on early-stage and seed investments, particularly in companies with groundbreaking commercial potential in sectors such as life sciences, biotechnology, physical sciences, and information technology. The firm looks for transformational opportunities often rooted in university or laboratory innovations, providing not just capital but operational guidance, commercialization resources, and industry access. ARCH is known for its willingness to fund and actively support ventures from their founding through growth and scale, embracing risk to drive major advances in science and technology.

Top Buys
V
VIRVIR BIOTECHNOLOGY INC.
+$65.1M
L
LYELLYELL IMMUNOPHARMA INC.
+$16.1M
V
VERVVERVE THERAPEUTICS INC.
+$13.4M
B
BEAMBEAM THERAPEUTICS INC.
-$11.4M
M
MAZEMAZE THERAPEUTICS INC.
+$5.2M
Top Sells
V
VIRVIR BIOTECHNOLOGY INC.
+$65.1M
L
LYELLYELL IMMUNOPHARMA INC.
+$16.1M
V
VERVVERVE THERAPEUTICS INC.
+$13.4M
B
BEAMBEAM THERAPEUTICS INC.
-$11.4M
M
MAZEMAZE THERAPEUTICS INC.
+$5.2M

Top Holdings

B
BEAMBEAM THERAPEUTICS INC.
+25.8%$77.2M
V
VIRVIR BIOTECHNOLOGY INC.
+21.8%$65.1M
M
MAZEMAZE THERAPEUTICS INC.
+16.9%$50.6M
R
RAPPRAPPORT THERAPEUTICS INC.
+14.2%$42.4M
V
VERVVERVE THERAPEUTICS INC.
+7.5%$22.6M

Equity Positions (10)

TickerSecurityWeightMarket ValueSharesAvg CostPriceChange (QoQ)
B
BEAM
BEAM THERAPEUTICS INC.25.82%$77.2M4,540,132$23.05$17.01-$11.4M
V
VIR
VIR BIOTECHNOLOGY INC.21.76%$65.1M12,916,663$5.04$5.04+$65.1M
M
MAZE
MAZE THERAPEUTICS INC.16.91%$50.6M4,120,053$11.01$12.27+$5.2M
R
RAPP
RAPPORT THERAPEUTICS INC.14.19%$42.4M3,728,738$25.44$11.37+$4.9M
V
VERV
VERVE THERAPEUTICS INC.7.54%$22.6M2,008,809$36.87$11.23+$13.4M

Industry Allocation

BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
+64.5%
PHARMACEUTICAL PREPARATIONS
+35.3%