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Foresite Capital Management IV, LLC

CIK:0001704132
Venture Capital
$124M AUM
6 holdings
Larkspur, CA, US
Founded:2011
50 employees
Latest filing:Jun 30, 2025

Foresite Capital Management IV, LLC is an investment fund managed by Foresite Capital, a multi-stage healthcare and life sciences investment firm headquartered in Larkspur, California. The firm was founded in 2011 and specializes in data- and science-driven strategies focusing on healthcare and life sciences companies, serving institutional investors including university endowments, pension funds, insurance companies, and foundations. Foresite Capital employs a multidisciplinary team and manages over $2 billion in assets across multiple funds. Fund IV, specifically, raised $668 million, expanding the firm's reach and expertise.

Investment Strategy

Foresite Capital Management IV employs a rigorous, data- and science-driven investment approach, funding promising businesses in areas of great unmet need within healthcare and life sciences. The firm invests in companies from seed stage through public markets, leveraging the expertise of scientists, clinicians, analysts, and engineers to derive meaningful insights from complex healthcare data. The focus is on supporting innovative therapeutics, diagnostics, and healthcare technologies through a multidisciplinary investment team.

Top Buys
P
PHVSPharvaris N.V.
+$8.4M
L
LYELLyell Immunopharma, Inc.
+$7.1M
X
XENEXenon Pharmaceuticals Inc
+$5.0M
M
MAZEMaze Therapeutics Inc
+$2.7M
K
KURAKura Oncology, Inc.
-$2.6M
Top Sells
L
LYELLyell Immunopharma, Inc.
-$8.6M
P
PHVSPharvaris N.V.
+$8.4M
L
LYELLyell Immunopharma, Inc.
+$7.1M
X
XENEXenon Pharmaceuticals Inc
+$5.0M
M
MAZEMaze Therapeutics Inc
+$2.7M

Top Holdings

P
PHVSPharvaris N.V.
+62.7%$77.6M
M
MAZEMaze Therapeutics Inc
+20.9%$25.9M
L
LYELLyell Immunopharma, Inc.
+5.7%$7.1M
X
XENEXenon Pharmaceuticals Inc
+4.0%$5.0M
K
KURAKura Oncology, Inc.
+3.8%$4.7M

Equity Positions (6)

TickerSecurityWeightMarket ValueSharesAvg CostPriceChange (QoQ)
P
PHVS
Pharvaris N.V.62.70%$77.6M4,410,581$25.74$17.60+$8.4M
M
MAZE
Maze Therapeutics Inc20.93%$25.9M2,111,919$11.01$12.27+$2.7M
L
LYEL
Lyell Immunopharma, Inc.5.72%$7.1M800,399$8.84$8.84+$7.1M
X
XENE
Xenon Pharmaceuticals Inc4.05%$5.0M160,000$31.30$31.30+$5.0M
K
KURA
Kura Oncology, Inc.3.81%$4.7M816,882$20.81$5.77-$2.6M

Industry Allocation

PHARMACEUTICAL PREPARATIONS
+76.3%
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
+23.7%