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TRV GP V, LLC
TRV GP V, LLC is a private investment fund manager based in Boston, Massachusetts. It manages private investment vehicles associated with Third Rock Ventures, a prominent venture capital firm focused primarily on the biotechnology and life sciences sector. The firm was founded as part of Third Rock’s ongoing fund family and is involved in early-stage funding, company building, and operational support for entrepreneurs and researchers. Key managers include Kevin Gillis, Reid Huber, Sarah Larson, Craig Muir, Robert Tepper, and Jeffrey Tong. The entity serves institutional investors and invests in innovative healthcare and biotechnology companies.
Investment Strategy
TRV GP V, LLC (affiliated with Third Rock Ventures) specializes in venture capital investments with an emphasis on early-stage life sciences and biotechnology companies. The firm seeks to actively build and support companies from inception, leveraging deep sector expertise to drive innovation in healthcare. Its portfolio composition typically includes high-potential therapeutics and medical technologies, with a hands-on approach that involves operational and strategic guidance.
Latest 13F Filing Activity
TRV GP V, LLC filed their most recent 13F report on Jun 30, 2025 disclosing 4 equity positions with a total 13F market value of $166M. The fund increased holdings in Septerna, Inc., Rapport Therapeutics, Inc., Maze Therapeutics, Inc. among other positions. TRV GP V, LLC reduced exposure to Cargo Therapeutics, Inc., Maze Therapeutics, Inc., Rapport Therapeutics, Inc. among others.
Top Holdings
Equity Positions (4)
| Ticker | Security | Weight | Market Value | Shares | Avg Cost | Price | Change (QoQ) |
|---|---|---|---|---|---|---|---|
R RAPP | RAPPORT THERAPEUTICS, INC. | 48.98% | $81.1M | 7,135,233 | $17.74 | $11.37 | +$9.6M |
S SEPN | SEPTERNA, INC. | 39.66% | $65.7M | 6,215,591 | $22.90 | $10.57 | +$29.7M |
M MAZE | MAZE THERAPEUTICS, INC. | 7.04% | $11.7M | 950,800 | $11.01 | $12.27 | +$1.2M |
C CRGX | CARGO THERAPEUTICS, INC. | 4.32% | $7.2M | 1,737,216 | $14.42 | $4.12 | +$86.9K |
Industry Allocation
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