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TRV GP V, LLC

CIK:0001990717
Venture Capital
$166M AUM
4 holdings
Boston, MA, US
Founded:2023
25 employees
Latest filing:Jun 30, 2025

TRV GP V, LLC is a private investment fund manager based in Boston, Massachusetts. It manages private investment vehicles associated with Third Rock Ventures, a prominent venture capital firm focused primarily on the biotechnology and life sciences sector. The firm was founded as part of Third Rock’s ongoing fund family and is involved in early-stage funding, company building, and operational support for entrepreneurs and researchers. Key managers include Kevin Gillis, Reid Huber, Sarah Larson, Craig Muir, Robert Tepper, and Jeffrey Tong. The entity serves institutional investors and invests in innovative healthcare and biotechnology companies.

Investment Strategy

TRV GP V, LLC (affiliated with Third Rock Ventures) specializes in venture capital investments with an emphasis on early-stage life sciences and biotechnology companies. The firm seeks to actively build and support companies from inception, leveraging deep sector expertise to drive innovation in healthcare. Its portfolio composition typically includes high-potential therapeutics and medical technologies, with a hands-on approach that involves operational and strategic guidance.

Top Buys
S
SEPNSEPTERNA, INC.
+$29.7M
R
RAPPRAPPORT THERAPEUTICS, INC.
+$9.6M
M
MAZEMAZE THERAPEUTICS, INC.
+$1.2M
C
CRGXCARGO THERAPEUTICS, INC.
+$86.9K
Top Sells
S
SEPNSEPTERNA, INC.
+$29.7M
R
RAPPRAPPORT THERAPEUTICS, INC.
+$9.6M
M
MAZEMAZE THERAPEUTICS, INC.
+$1.2M
C
CRGXCARGO THERAPEUTICS, INC.
+$86.9K

Top Holdings

R
RAPPRAPPORT THERAPEUTICS, INC.
+49.0%$81.1M
S
SEPNSEPTERNA, INC.
+39.7%$65.7M
M
MAZEMAZE THERAPEUTICS, INC.
+7.0%$11.7M
C
CRGXCARGO THERAPEUTICS, INC.
+4.3%$7.2M

Equity Positions (4)

TickerSecurityWeightMarket ValueSharesAvg CostPriceChange (QoQ)
R
RAPP
RAPPORT THERAPEUTICS, INC.48.98%$81.1M7,135,233$17.74$11.37+$9.6M
S
SEPN
SEPTERNA, INC.39.66%$65.7M6,215,591$22.90$10.57+$29.7M
M
MAZE
MAZE THERAPEUTICS, INC.7.04%$11.7M950,800$11.01$12.27+$1.2M
C
CRGX
CARGO THERAPEUTICS, INC.4.32%$7.2M1,737,216$14.42$4.12+$86.9K

Industry Allocation

PHARMACEUTICAL PREPARATIONS
+88.6%
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
+11.4%