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Omega Fund Management, LLC

CIK:0001637359
Venture Capital
$2B AUM
13 holdings
Boston, MA, United States
Founded:2004
23 employees
Latest filing:Jun 30, 2025

Omega Fund Management, LLC is a Boston-based venture capital firm founded in 2004 focused on supporting exceptional founders and entrepreneurs developing impactful products and platforms across multiple therapeutic areas. The firm specializes in life sciences and biotechnology investments, operates internationally, and employs approximately 23 professionals, serving institutional investors and emerging companies in the healthcare and biopharmaceutical sectors.

Investment Strategy

Omega Fund Management specializes in providing venture capital to companies in the life sciences and healthcare sectors, targeting opportunities with transformative potential in biotechnology and therapeutics. The firm partners with exceptional scientific founders and entrepreneurs, leveraging its deep industry experience, operational expertise, and global network to accelerate portfolio company growth. Omega emphasizes impactful innovation, cross-stage investments, and long-term partnerships to maximize value creation.

Top Buys
U
UPBUpstream Bio Inc.
+$9.9M
B
BBNXBeta Bionics Inc.
+$4.6M
A
ALMSAlumis Inc.
-$2.1M
N
NUVBNuvation Bio
-$1.5M
R
REPLReplimune Group
-$908.6K
Top Sells
K
KMTSKestra Med Technologies Ltd.
-$17.5M
B
BCAXBicara Therapeutics Inc.
-$8.2M
A
ALMSAlumis Inc.
-$2.1M
N
NUVBNuvation Bio
-$1.5M
R
REPLReplimune Group
-$908.6K

Top Holdings

B
BBNXBeta Bionics Inc.
+18.7%$28.9M
K
KMTSKestra Med Technologies Ltd.
+17.7%$27.3M
U
UPBUpstream Bio Inc.
+14.5%$22.4M
N
NUVBNuvation Bio
+13.9%$21.5M
B
BCAXBicara Therapeutics Inc.
+13.3%$20.5M

Equity Positions (12)

TickerSecurityWeightMarket ValueSharesAvg CostPriceChange (QoQ)
B
BBNX
Beta Bionics Inc.18.75%$28.9M1,988,287$12.24$14.56+$4.6M
K
KMTS
Kestra Med Technologies Ltd.17.67%$27.3M1,645,893$24.92$16.58-$17.5M
U
UPB
Upstream Bio Inc.14.48%$22.4M2,036,293$16.44$10.98+$9.9M
N
NUVB
Nuvation Bio13.94%$21.5M11,042,728$10.45$1.95-$1.5M
B
BCAX
Bicara Therapeutics Inc.13.26%$20.5M2,204,650$25.47$9.29-$8.2M

Industry Allocation

PHARMACEUTICAL PREPARATIONS
+43.8%
SURGICAL & MEDICAL INSTRUMENTS & APPARATUS
+36.4%
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
+19.6%