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Aakash Tiwari

Managing Director and Global Head of Biopharmaceutical Research at Jefferies Financial Group Inc.

Akash Tewari is a Managing Director and Global Head of Biopharmaceutical Research at Jefferies, specializing in equity research covering the biotech and pharmaceutical sectors with a focus on SMID Cap Biotech companies. He has demonstrated consistent performance as a recognized top-ranked analyst, maintaining a 38-39% success rate with an average return of 3.2-3.82% per rating across his 455+ stock ratings since 2018, with notable achievements including a +400.60% return on his highest-performing recommendation. Tewari's career spans over a decade in equity research, beginning at Evercore as a Vice President and Biotech Analyst from 2015-2018, followed by a Senior Analyst role at Wolfe Research from 2018-2021, before joining Jefferies in 2021 where he has led biopharmaceutical research coverage. He holds an undergraduate degree from Cornell University and maintains FINRA registration as a regulated broker.

Aakash Tiwari's questions to PFIZER (PFE) leadership

Question · Q4 2025

Aakash Tiwari from Jefferies Financial Group Inc. questioned the confidence in delivering a superior profile with the upcoming Phase 3 study for SV (sigvotatug vedotin) in second-line plus non-squamous metastatic non-small cell lung cancer (mNSCLC) against docetaxel, and whether enrichment in B6A high-expressing patients would be necessary, asking for expectations for this readout.

Answer

Dr. Chris Boshoff, Chief Scientific Officer, Pfizer, clarified that SV is being studied in a second-line trial against docetaxel and a first-line trial with pembrolizumab. He highlighted single-agent activity with over 30% response rate and 16.3 months median overall survival in Phase 2, and 57% overall response rate with pembrolizumab. He expressed confidence in the trials, noting that the second-line study against docetaxel would read out first, despite other ADCs not showing benefit over docetaxel in this setting.

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