Question · Q4 2025
Aakash Tiwari from Jefferies Financial Group Inc. questioned the confidence in delivering a superior profile with the upcoming Phase 3 study for SV (sigvotatug vedotin) in second-line plus non-squamous metastatic non-small cell lung cancer (mNSCLC) against docetaxel, and whether enrichment in B6A high-expressing patients would be necessary, asking for expectations for this readout.
Answer
Dr. Chris Boshoff, Chief Scientific Officer, Pfizer, clarified that SV is being studied in a second-line trial against docetaxel and a first-line trial with pembrolizumab. He highlighted single-agent activity with over 30% response rate and 16.3 months median overall survival in Phase 2, and 57% overall response rate with pembrolizumab. He expressed confidence in the trials, noting that the second-line study against docetaxel would read out first, despite other ADCs not showing benefit over docetaxel in this setting.
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