Question · Q4 2025
Umar Rafiq from Evercore Inc. asked if the 9.6 mg monthly dose for the GLP-1 monotherapy was a reaction to current data or previously contemplated, and inquired about the emerging tolerability data for the GLP-1 plus amylin combination, specifically if it could be delivered in a single pill.
Answer
Dr. Chris Boshoff, Chief Scientific Officer, Pfizer, clarified that the 9.6 mg monthly dose is equivalent to the 2.4 mg weekly dose already being tested in VESPER-4, and this decision was based on modeling-based meta-analysis. He stated that the GLP-1 plus amylin combination is a monthly subcutaneous injection, not a pill, but mentioned Pfizer's separate oral portfolio including GLP-1 and GIP. He also noted that early data for the combination showed 5% weight loss at day 8, with updated data expected later this year.
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