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    MoonLake Immunotherapeutics (MLTX)

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    MoonLake Immunotherapeutics (MLTX) is a clinical-stage biotechnology company focused on developing therapies for inflammatory skin and joint diseases. The company is primarily engaged in the development of Sonelokimab (SLK), a novel tri-specific IL-17A and IL-17F inhibiting Nanobody. MLTX aims to address significant unmet needs in dermatology and rheumatology through its innovative therapeutic approach.

    1. Sonelokimab (SLK) - Develops a tri-specific IL-17A and IL-17F inhibiting Nanobody for treating inflammatory diseases such as Hidradenitis Suppurativa, Psoriatic Arthritis, and Psoriasis. SLK offers advantages like high affinity, selective binding, and enhanced tissue penetration due to its small size and albumin-binding domain.
    NamePositionExternal RolesShort Bio

    Dr. Jorge Santos da Silva

    Executive

    Chief Executive Officer

    Professor and Board Advisor at the School of Medicine at Minho University (Portugal).

    Co-founder of MoonLake AG; leads MLTX's development of Nanobody® sonelokimab for inflammatory diseases.

    View Report →

    Dr. Kristian Reich

    Executive

    Chief Scientific Officer

    Guest-Professor at University Medical Center Hamburg-Eppendorf; Medical Advisor at TFS HealthScience; Board Member at Derma2go AG, Dermagnostix GmbH, and ProDerma Foundation.

    Co-founder of MoonLake AG; global clinical leader in dermatology and immunology with over 25 years of experience and 300+ peer-reviewed publications.

    Matthias Bodenstedt

    Executive

    Chief Financial Officer

    None

    Former McKinsey Partner; oversees MLTX's financial strategy, including maintaining a strong cash position and supporting clinical development programs.

    Catherine Moukheibir

    Board

    Director

    Chair of Audit Committees at Ironwood Pharmaceuticals, Biotalys, Oxford Biomedica, CMR Surgical, Asceneuron, and DNA Script.

    Financial expert with extensive board experience in life sciences companies across the U.S. and Europe.

    Dr. Andrew Phillips

    Board

    Director

    CEO and President of Aleksia Therapeutics, Nexo Therapeutics, and Blossom Bioscience; Director at Enliven Therapeutics and multiple private biotechnology companies.

    Leader in life sciences-focused investment management and executive roles in biopharmaceutical companies.

    Dr. Ramnik Xavier

    Board

    Director

    Core Institute Member at Broad Institute; Director of Klarman Cell Observatory and Broad's Immunology Program; Co-Director of Broad's Infectious Disease and Microbiome Program; Professor at Harvard Medical School.

    Renowned biomedical researcher specializing in genetic variants, computational biology, and immunology; holds multiple leadership roles at prestigious institutions.

    Simon Sturge

    Board

    Independent Chairperson

    Director at Galapagos NV; Director at two private biotechnology companies, a private consulting company, and a private investment company.

    Former CEO of Kymab Ltd and COO of Merck Group Germany; extensive experience in biotechnology and pharmaceutical leadership.

    Spike Loy

    Board

    Director

    Managing Director at BVF Partners L.P.; Director at multiple private biopharmaceutical companies.

    Experienced in life sciences investment management and biopharmaceutical company leadership.

    Notable M&A activity and strategic investments in the past 3 years.

    CompanyYearDetails

    MoonLake Immunotherapeutics AG

    2022

    Deal value and structure: Completed on April 5, 2022, under a Business Combination Agreement dated October 4, 2021, with Helix Acquisition Corp. contributing $134,646,009 (including a $15,000,000 loan repayment), converting Series A preferred to common shares and issuing new classes of shares. Strategic rationale and capabilities: The acquisition advanced the development of Sonelokimab, a novel Nanobody® for treating inflammatory diseases, and repositioned the company with a new Nasdaq listing under MLTX.

    Merck Healthcare KGaA (SLK program)

    2021

    Strategic rationale and capabilities: The SLK program, focused on a tri-specific IL-17A/F nanobody that binds human albumin to extend its half-life, is positioned to be best-in-class for IL-17-driven inflammatory diseases, especially in a $44 billion market, with robust Phase II data in psoriasis supporting its development. Notable aspects: Although detailed deal value and structure were not provided, the acquisition strategically expands MoonLake's asset portfolio to target multiple inflammatory indications and compete against drugs like Bimekizumab.

    Recent press releases and 8-K filings for MLTX.

    MoonLake Capital Markets Day 2025 Update
    MLTX
    New Projects/Investments
    Debt Issuance
    Product Launch
    • VELA Phase 3 in HS achieved record recruitment with 800 patients across 17 countries in ~12 months, outperforming industry benchmarks.
    • The company emphasized its strong financial footing with a up to $500m non-dilutive facility and a cash runway extended into 2028.
    • Multiple clinical programs, including the PPP LEDA trial, are progressing, supporting a pipeline aimed for market launch in 2027.
    1 day ago
    MoonLake Immunotherapeutics Secures $500 Million NonDilutive Financing
    MLTX
    Debt Issuance
    New Projects/Investments
    • MoonLake Immunotherapeutics secured up to $500 million in non-dilutive financing from Hercules Capital, with an initial drawdown of $75 million, bolstering its balance sheet and strategic funding flexibility.
    • The new facility complements an existing cash position of $448 million and is expected to fund advancements in clinical trials and further investments, including the anticipated 2027 launch of sonelokimab.
    • A Capital Markets Update is scheduled for April 29, 2025 in New York to discuss clinical milestones, including updates on the Phase 3 HS (VELA) program and an interim readout from the Phase 2 LEDA trial.
    Apr 3, 2025, 12:00 AM