Dafna Capital Management LLC
DAFNA Capital Management LLC is an SEC-registered investment adviser based in Los Angeles, California. Founded in 1999, the firm specializes in managing investments in the healthcare and life sciences sectors. With a small, focused team and led by CEO Nathan Fischel, DAFNA serves institutional and accredited investors by providing investment management focused on innovative biotech and medical technology companies.
Investment Strategy
DAFNA Capital Management LLC pursues a research-driven, fundamentals-based investment approach, primarily focusing on innovative companies in the healthcare and life sciences sectors. The firm aims to identify and invest in small to mid-cap companies developing breakthrough therapies, devices, and diagnostics with the potential for significant market impact. DAFNA seeks value creation through deep scientific and financial due diligence, active portfolio management, and a disciplined risk strategy, often supporting companies with attractive long-term growth potential in under-researched segments.
Latest 13F Filing Activity
Dafna Capital Management LLC filed their most recent 13F report on Jun 30, 2025 disclosing 73 equity positions with a total 13F market value of $362M. The fund increased holdings in Blueprint Medicines Corp., Stereotaxis Inc., Ideaya Biosciences Inc. among other positions. Dafna Capital Management LLC reduced exposure to Axogen Inc., Cytokinetics Inc., Biocryst Pharmaceuticals Inc. among others.
Top Holdings
Equity Positions (73)
| Ticker | Security | Weight | Market Value | Shares | Avg Cost | Price | Change (QoQ) |
|---|---|---|---|---|---|---|---|
X XBI | SPDR S&P BIOTECH ETF | 9.51% | $34.5M | 415,505 | $81.50 | $82.93 | +$1.7M |
S STXS | STEREOTAXIS INC | 8.01% | $29.0M | 13,680,554 | $0.88 | $2.12 | +$4.9M |
R RVMD | REVOLUTION MEDICINES INC | 6.88% | $24.9M | 677,176 | $31.41 | $36.79 | +$1.7M |
B BPMC | BLUEPRINT MEDICINES CORP | 5.97% | $21.6M | 168,763 | $72.91 | $128.18 | +$8.2M |
M MRUS | MERUS BV | 5.79% | $21.0M | 398,804 | $28.72 | $52.60 | +$1.5M |
Industry Allocation
Investment Team (2)
| Name | Role | Location | |
|---|---|---|---|
 | Analyst | Los Angeles, CA , United States | |
D Daphna Fischel | Research Analyst | Los Angeles, CA , United States |
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