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Blueprint Medicines (BPMC)

Earnings summaries and quarterly performance for Blueprint Medicines.

Board of directors at Blueprint Medicines.

Recent press releases and 8-K filings for BPMC.

Blueprint Medicines Corporation Acquired by SANOFI Subsidiary for $9.1 Billion Plus CVRs
BPMC
M&A
Takeover Bid
Delisting/Listing Issues
  • Blueprint Medicines Corporation (BPMC) completed its merger with Rothko Merger Sub, Inc., a wholly owned subsidiary of SANOFI's Aventis Inc., on July 17, 2025.
  • The acquisition was structured as a tender offer, with shareholders receiving $129.00 per Share in cash plus one non-transferable contractual contingent value right (CVR) per Share.
  • Each CVR represents the right to receive contingent payments of up to an aggregate amount of $6.00 per Share in cash upon the achievement of specified milestones.
  • The aggregate cash consideration paid by the Purchaser for the shares in the offer and merger was approximately $9.1 billion.
  • As a result of the merger, BPMC became a wholly owned subsidiary of Aventis, and its shares will be delisted from Nasdaq.
Jul 18, 2025, 12:00 AM
Blueprint Medicines presents long-term AYVAKIT data at 2025 EHA and EAACI congresses
BPMC
  • Blueprint Medicines showcased a decade of collaboration and data presentations for AYVAKIT®/AYVAKYT® at the 2025 EHA and EAACI congresses, emphasizing its role as a durable standard of care in both indolent and advanced systemic mastocytosis.
  • PIONEER three-year results demonstrated sustained symptom improvements through 144 weeks, with a 3 % discontinuation rate due to treatment-related adverse events and a median exposure of three years (some patients treated up to five years).
  • PATHFINDER and EXPLORER multi-year analyses showed prolonged overall survival with AYVAKIT versus real-world midostaurin data across all risk categories, validated by the new MARS-R prognostic tool.
  • PRISM survey data highlighted the substantial real-world burden of indolent systemic mastocytosis on patients’ physical, social and emotional well-being.
Jun 12, 2025, 10:01 PM
Blueprint Medicines Acquisition Announced by Sanofi
BPMC
M&A
  • Sanofi announced it will acquire Blueprint Medicines to expand its portfolio in rare immunological diseases and boost its early-stage immunology pipeline.
  • The acquisition includes Blueprint’s approved Ayvakit/Ayvakyt for systemic mastocytosis and advanced candidates like elenestinib and BLU‑808.
  • The deal terms feature a cash offer of $129.00 per share (totaling approximately $9.1 billion) plus contingent value rights for potential milestone payments.
Jun 2, 2025, 12:00 AM
Blueprint Medicines Q1 2025 Earnings & Clinical Update
BPMC
Earnings
Guidance Update
Revenue Acceleration/Inflection
  • Q1 2025 net product revenues reached $149.4M from AYVAKIT/AYVAKYT sales—including $129.4M in the U.S.—with 61% YoY growth .
  • Raised full-year AYVAKIT net product revenue guidance to $700–$720M, supporting a longer-term target of $2B by 2030 .
  • Robust growth in patient starts and prescriber expansion driven by targeted allergist initiatives and plans to expand into dermatology and gastroenterology .
  • Clinical progress includes advancement in the HARBOR study of elenestinib and initiation of BLU-808 proof-of-concept studies for allergic rhinoconjunctivitis and chronic urticaria, with a sustained favorable safety profile over three years .
  • Demonstrated a strong balance sheet with an approximate cash position of $900M, including a $78.7M boost from an equity investment sale .
May 1, 2025, 12:01 PM
Blueprint Medicines Showcases Mast Cell Therapy Data at AAAAI/WAO Joint Congress
BPMC
New Projects/Investments
  • AYVAKIT demonstrated strong long-term efficacy and safety in ISM with three-year follow-up data from the PIONEER trial, showing durable symptom improvement and positive effects on bone health.
  • BLU-808 displayed a wide therapeutic window and favorable tolerability in Phase 1 trials, supporting its potential as a first-in-class oral wild-type KIT inhibitor.
Feb 28, 2025, 1:00 PM
Blueprint Medicines Q4 & FY2024 Results with 2025 Guidance & Strategic Updates
BPMC
Earnings
Guidance Update
Revenue Acceleration/Inflection
  • Q4 2024 & FY2024 Performance: Reported Q4 total revenue of $146.4M (with $144.1M in net product sales and a $50.0M net loss) and full-year revenue of $508.8M.
  • AYVAKIT Growth: Achieved $479.0M in net product revenues in 2024 (including $144.1M in Q4) with 135% YoY growth, driven by strong performance in both US and ex‑US markets.
  • 2025 Guidance: Expects global AYVAKIT revenues of $680–710M (approx. 45% YoY growth) with a long-term target of $2B by 2030, alongside an updated systemic mastocytosis franchise peak opportunity of $4B.
  • Strategic & Clinical Updates: Highlighted the presentation of 14 abstracts at major conferences, promising Phase 1 healthy volunteer data for BLU-808, and increased investments in R&D, SG&A, commercial infrastructure, and field team expansion supported by a robust cash position of $864M and reduced operating cash burn.
Feb 13, 2025, 12:00 PM