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    Blueprint Medicines Corp (BPMC)

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    Blueprint Medicines Corporation (BPMC) is a global, fully-integrated biopharmaceutical company focused on inventing life-changing medicines. The company specializes in drug discovery and development, particularly in the areas of allergy/inflammation and oncology/hematology. BPMC sells innovative therapies that target the primary drivers of disease, including approved medicines and investigational programs.

    1. AYVAKIT/AYVAKYT - Markets avapritinib for systemic mastocytosis (SM) and PDGFRA Exon 18 mutant GIST in the U.S. and Europe, serving as the cornerstone of their mast cell disease franchise.
    2. Collaboration, License, and Other Agreements - Engages in strategic collaborations with companies like CStone, Zai Lab, Roche, Clementia, Rigel, and Alexion Pharma Holding to advance drug development and commercialization efforts.
    3. Pipeline and Research Programs - Advances a broad pipeline of investigational programs in mast cell diseases, breast cancer, and other solid tumors, including drug candidates like elenestinib (BLU-263), BLU-222, BLU-808, and BLU-956.
    NamePositionExternal RolesShort Bio

    Debra Durso-Bumpus

    ExecutiveBoard

    Chief People Officer

    Member of the Board of Directors for the Massachusetts Biotechnology Education Foundation

    Debra Durso-Bumpus is the Chief People Officer at BPMC since February 2020 and previously served as Senior Vice President, Human Resources from April 2015 to February 2020. She also serves on the board of the Massachusetts Biotechnology Education Foundation.

    Kathryn Haviland

    ExecutiveBoard

    President and Chief Executive Officer

    Chairperson of Fulcrum Therapeutics, Inc.

    Kathryn Haviland has been the CEO of BPMC since 2022, following her roles as Chief Operating Officer (2019–2022) and Chief Business Officer (2016–2019). She also serves as a Director on the BPMC board since 2022, demonstrating extensive leadership in the biopharmaceutical sector.

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    Philina Lee

    ExecutiveBoard

    Chief Commercial Officer

    Board of Directors Member at Fusion Pharmaceuticals; Member of Nominating and Corporate Governance Committee at Fusion Pharmaceuticals; Member of Research and Development Committee at Fusion Pharmaceuticals

    Philina Lee is the Chief Commercial Officer at BPMC since April 2022, leading the company’s commercial strategy and successful product launches; she previously held roles such as Senior Vice President and Vice President at BPMC.

    Ariel Hurley

    Executive

    Senior Vice President, Finance and Principal Accounting Officer

    Ariel Hurley has served as Senior Vice President, Finance and Principal Accounting Officer at BPMC since January 2023, and previously held executive finance roles including Vice President, Finance from March 2019 to December 2022.

    Becker Hewes

    Executive

    Chief Medical Officer

    Becker Hewes, M.D. is the Chief Medical Officer at BPMC since January 2021, and previously served as Senior Vice President of Clinical Development from May 2020 to January 2021.

    Christina Rossi

    Executive

    Chief Operating Officer

    Member of the Board of Directors at Xilio Therapeutics ; Audit Committee Member at Xilio Therapeutics ; Chair of Compensation Committee at Xilio Therapeutics

    Christina Rossi has served as the COO at BPMC since April 2022, after serving as CCO from October 2018 to April 2022, and holds active board roles at Xilio Therapeutics since April 2021.

    Christopher K. Murray

    Executive

    Chief Technical Operations and Quality Officer

    Christopher K. Murray, Ph.D., has been serving as Chief Technical Operations and Quality Officer at BPMC since January 2023. He previously served as Senior Vice President, Technical Operations from October 2017 to December 2022.

    Fouad Namouni

    Executive

    President, Research and Development

    Fouad Namouni is the President, Research and Development at BPMC since September 2020, and he leverages over 20 years of expertise in oncology and cancer immunotherapy drug development. Previously, he held several leadership roles at Bristol Myers Squibb from 1999 to 2020.

    Michael Landsittel

    Executive

    Chief Financial Officer

    Michael Landsittel has been the Chief Financial Officer of Blueprint Medicines Corporation since January 2019. He previously served as Vice President, Finance from February 2016 to January 2019 and as Senior Director, Finance from September 2014 to February 2016 at the company.

    Percy H. Carter

    Executive

    Chief Scientific Officer

    Board of Directors of HiFiBio Therapeutics

    Percy H. Carter, M.B.A., Ph.D. has served as the Chief Scientific Officer at BPMC since May 2021. He is also an independent board member of HiFiBio Therapeutics since 2022.

    Tracey L. McCain

    Executive

    Executive Vice President and Chief Legal Officer

    Board of Directors of Kiniksa Pharmaceuticals, Ltd. (Audit Committee) ; Board of Trustees of the Dana Farber Cancer Institute

    Tracey L. McCain has served as BPMC's Executive Vice President and Chief Legal Officer since September 2016 and as Chief Compliance Officer since June 2017, bringing extensive legal and compliance expertise from her previous leadership roles at Sanofi Genzyme and Genzyme Corporation.

    Alexis Borisy

    Board

    Director

    Revolution Medicines, Inc. (since 2014); Relay Therapeutics, Inc. (since 2016); Tango Therapeutics, Inc. (since 2017)

    Alexis Borisy has served as a director at BPMC since April 2011. He previously served as the interim CEO from May 2013 through July 2014.

    Daniella Beckman

    Board

    Independent Director

    Chair of the Audit Committee at Vor Biopharma Inc.; Member of the Compensation Committee at Vor Biopharma Inc.

    Daniella Beckman has served as an Independent Director at BPMC since 2021 and currently chairs the Audit Committee as the designated Audit Committee Financial Expert. Previously, she served as CFO at Tango Therapeutics starting in 2019 and has held significant financial leadership roles in various biotechnology companies.

    Habib Dable

    Board

    Independent Director

    Part-time Venture Partner at RA Capital Management since 2022; Advisor at GLG Institute since 2022; Board Member at PepGen Inc. since 2022; Chair at Aerovate Therapeutics, Inc. since 2023; Board Member at Day One Biopharmaceuticals, Inc. since 2024

    Habib Dable has served as an Independent Director at BPMC since 2022, contributing to the Compensation and Nominating and Corporate Governance Committees. Previously, he was CEO of Acceleron Pharma from 2016 to 2021 and held various leadership roles at Bayer from 1994 to 2016.

    Jeffrey W. Albers

    Board

    Chairperson of the Board

    Venture Partner at Atlas Venture; Director at Kymera Therapeutics, Inc.; Director at Spyre Therapeutics, Inc.

    Jeffrey W. Albers served as CEO from 2014 until April 3, 2022 and has led BPMC as Chairperson of the Board since June 2021, providing strategic guidance and leadership.

    John Tsai

    Board

    Independent Director

    Executive Partner at Syncona Limited; Chief Executive Officer at Forcefield Therapeutics Limited

    John Tsai, M.D. has served as an independent director at BPMC since January 6, 2023. He brings over 20 years of pharmaceutical industry experience from leadership roles at companies including Novartis, Amgen, and Bristol-Myers Squibb.

    Lonnel Coats

    Board

    Independent Director

    Board Member at Lexicon Pharmaceuticals, Inc. since 2014 ; Audit Committee Member at Verve Therapeutics, Inc. since 2022

    Lonnel Coats has been an independent director at Blueprint Medicines Corporation since 2016. He also serves as the Chair of the Nominating and Corporate Governance Committee and as a member of the Audit Committee with a designation as an Audit Committee Financial Expert.

    Lynn Seely

    Board

    Lead Independent Director

    President and Chief Executive Officer, Lyell Immunopharma, Inc.

    Lynn Seely, M.D. has served as an Independent Director at BPMC since 2016 and as Lead Independent Director since June 2021. She also chairs the Compensation Committee and sits on the Nominating and Corporate Governance Committee, while externally serving as President and Chief Executive Officer of Lyell Immunopharma, Inc. since 2022.

    Mark Goldberg

    Board

    Independent Director

    Lecturer in Medicine at Harvard Medical School (since 2021); Faculty Member, Hematology Division, Brigham and Women’s Hospital (since 1987); Advisor at CANbridge Life Sciences Ltd. (since 2018); Chair of the Nominating and Corporate Governance Committee, GlycoMimetics, Inc. (since 2014); Board Member, Avacta Group plc (since 2021)

    Mark Goldberg, M.D., has served as an Independent Director at Blueprint Medicines Corporation (BPMC) since 2015. He is also active in academia and the biopharmaceutical industry, holding roles as a Lecturer in Medicine at Harvard Medical School since 2021 and as a Faculty Member in the Hematology Division at Brigham and Women’s Hospital since 1987.

    Nicholas Lydon

    Board

    Scientific Founder

    Co-Founder of IDRx, Inc. (since 2021); Co-Founder, Scientific Advisor and Board Member of Recludix Pharma Inc. (since 2019); Co-Founder and Managing Member of VB Therapeutics LLC (since 2019); Co-Founder and Managing Member of Staurus Biopharma, LLC (since 2019)

    Nicholas Lydon, Ph.D., is the Scientific Founder of BPMC and has been a board member since April 2011. He also serves as the chair of the research and development committee at BPMC.

    1. Given your comments on growth across specialties, can you provide more detail on how incremental patient identification and treatment from med derms and GI docs will contribute to overall market expansion alongside your core hematology/oncology and allergist segments?
    2. While you highlighted a significant reduction in operating cash burn from 2023 to 2024, what specific milestones or operational cost drivers need to align before you can confidently claim cash flow positivity?
    3. Can you elaborate on the expected tangible impact of your field team expansion, particularly in terms of the number of additional patient interactions driven by med derms and GI providers, and how this will translate into measurable revenue growth?
    4. With many prescribers currently managing only one AYVAKIT patient, how do you plan to accelerate deeper adoption among existing providers, and what proportion of 2025’s growth do you expect from current versus new prescriber engagement?
    5. Considering your guidance aims to ramp AYVAKIT revenue to $2 billion by 2030, what are the key strategic levers and assumptions driving the incremental leap to a $4 billion franchise peak, and how will you manage competitive pressures along this trajectory?

    Competitors mentioned in the company's latest 10K filing.

    CompanyDescription

    AYVAKIT/AYVAKYT and elenestinib (BLU-263) face competition for advanced systemic mastocytosis (SM) from midostaurin and imatinib developed by this company.

    Alys Pharmaceuticals Inc.

    AYVAKIT/AYVAKYT and elenestinib (BLU-263) may face competition from drug candidates in development for advanced SM and non-advanced SM from this company.

    AYVAKIT/AYVAKYT and elenestinib (BLU-263) may face competition from drug candidates in development for advanced SM and non-advanced SM from this company.

    AYVAKIT/AYVAKYT and elenestinib (BLU-263) may face competition from drug candidates in development for advanced SM and non-advanced SM from this company.

    AB Science S.A.

    Avapritinib and elenestinib may face non-advanced SM competition from drug candidates in development from this company.

    Avapritinib and elenestinib may face non-advanced SM competition from drug candidates in development from this company.

    Invea Therapeutics Inc.

    Avapritinib and elenestinib may face non-advanced SM competition from drug candidates in development from this company.

    Telios Pharma Inc.

    Avapritinib and elenestinib may face non-advanced SM competition from drug candidates in development from this company.

    ARIAD Pharmaceuticals, Inc.

    AYVAKIT/AYVAKYT may face competition from drug candidates in development for PDGFRA-driven GIST from this company, a wholly-owned subsidiary of Takeda Pharmaceutical Company Limited.

    AROG Pharmaceuticals, Inc.

    AYVAKIT/AYVAKYT may face competition from drug candidates in development for PDGFRA-driven GIST from this company.

    AYVAKIT/AYVAKYT may face competition from drug candidates in development for PDGFRA-driven GIST from this company.

    Deciphera Pharmaceuticals, LLC

    AYVAKIT/AYVAKYT may face competition from drug candidates in development for PDGFRA-driven GIST from this company.

    AYVAKIT/AYVAKYT may face competition from drug candidates in development for PDGFRA-driven GIST from this company.

    Ningbo Tai Kang Medical Technology Co. Ltd.

    AYVAKIT/AYVAKYT may face competition from drug candidates in development for PDGFRA-driven GIST from this company.

    AYVAKIT/AYVAKYT may face competition from drug candidates in development for PDGFRA-driven GIST from this company.

    Genentech

    BLU-808 for chronic urticaria, asthma, allergic rhinitis, MCAS and other allergy/inflammation indications, if approved, will face competition from omalizumab developed by this company.

    Alivexis, Inc.

    BLU-808 may face competition from drug candidates in development from this company.

    BLU-808 may face competition from drug candidates in development from this company.

    BLU-808 may face competition from drug candidates in development from this company.

    BLU-808 may face competition from drug candidates in development from this company.

    Escient Pharmaceuticals, Inc.

    BLU-808 may face competition from drug candidates in development from this company.

    Evommune, Inc.

    BLU-808 may face competition from drug candidates in development from this company.

    Hangshou Highlightll Pharma

    BLU-808 may face competition from drug candidates in development from this company.

    BLU-808 may face competition from drug candidates in development from this company.

    BLU-808 may face competition from drug candidates in development from this company.

    Leo Pharma A/S

    BLU-808 may face competition from drug candidates in development from this company.

    LongBio Pharma

    BLU-808 may face competition from drug candidates in development from this company.

    BLU-808 may face competition from drug candidates in development from this company.

    BLU-808 may face competition from drug candidates in development from this company.

    BLU-808 may face competition from drug candidates in development from this company.

    Taiho Pharmaceutical Co., LTD

    BLU-808 may face competition from drug candidates in development from this company.

    United BioPharma

    BLU-808 may face competition from drug candidates in development from this company.

    Notable M&A activity and strategic investments in the past 3 years.

    CompanyYearDetails

    Lengo Therapeutics, Inc.

    2021

    Recent press releases and 8-K filings for BPMC.

    Blueprint Medicines Reports Q1 2025 Earnings & Clinical Update
    BPMC
    Earnings
    Revenue Acceleration/Inflection
    Guidance Update
    • Q1 2025 net product revenues reached $149.4M with 61% YoY growth from AYVAKIT/AYVAKYT sales
    • Raised full-year AYVAKIT revenue guidance to $700–$720M, supporting the longer-term target of $2B by 2030
    • Clinical progress includes advancement in the HARBOR study of elenestinib and initiation of BLU-808 proof-of-concept studies targeting allergic rhinoconjunctivitis and chronic urticaria
    • Demonstrated a strong balance sheet with an approximate cash position of $900M, including a $78.7M boost from an equity investment sale
    17 hours ago
    Blueprint Medicines Showcases Mast Cell Therapy Data at AAAAI/WAO Joint Congress
    BPMC
    New Projects/Investments
    • AYVAKIT demonstrated strong long-term efficacy and safety in ISM with three-year follow-up data from the PIONEER trial, showing durable symptom improvement and positive effects on bone health.
    • BLU-808 displayed a wide therapeutic window and favorable tolerability in Phase 1 trials, supporting its potential as a first-in-class oral wild-type KIT inhibitor.
    Feb 28, 2025, 1:00 PM
    Blueprint Medicines Q4 & FY2024 Results with 2025 Guidance & Strategic Updates
    BPMC
    Earnings
    Guidance Update
    Revenue Acceleration/Inflection
    • Q4 2024 & FY2024 Performance: Reported Q4 total revenue of $146.4M (with $144.1M in net product sales and a $50.0M net loss) and full-year revenue of $508.8M.
    • AYVAKIT Growth: Achieved $479.0M in net product revenues in 2024 (including $144.1M in Q4) with 135% YoY growth, driven by strong performance in both US and ex‑US markets.
    • 2025 Guidance: Expects global AYVAKIT revenues of $680–710M (approx. 45% YoY growth) with a long-term target of $2B by 2030, alongside an updated systemic mastocytosis franchise peak opportunity of $4B.
    • Strategic & Clinical Updates: Highlighted the presentation of 14 abstracts at major conferences, promising Phase 1 healthy volunteer data for BLU-808, and increased investments in R&D, SG&A, commercial infrastructure, and field team expansion supported by a robust cash position of $864M and reduced operating cash burn.
    Feb 13, 2025, 12:00 PM