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AstraZeneca (AZN) is a global, science-led biopharmaceutical company headquartered in Cambridge, UK. The company focuses on the discovery, development, and commercialization of prescription medicines to address unmet medical needs. Its portfolio spans innovative treatments in oncology, rare diseases, and biopharmaceuticals, with a strong emphasis on improving patient outcomes through cutting-edge research and strategic collaborations.
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Oncology - Develops innovative cancer treatments, including targeted therapies like Tagrisso and Iressa for lung cancer, and immuno-oncology drugs such as Imfinzi and Imjudo. Collaborates on next-generation therapies like Enhertu and Orpathys.
- Tagrisso - Targets EGFR-mutated lung cancer.
- Imfinzi - Focuses on immuno-oncology applications.
- Enhertu - A HER2-directed antibody-drug conjugate developed with Daiichi Sankyo.
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Cardiovascular, Renal & Metabolism (CVRM) - Focuses on treatments for chronic cardiovascular diseases, renal conditions, and metabolic disorders. Key products include Farxiga for heart failure and Lokelma for hyperkalemia.
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Rare Diseases - Specializes in therapies for conditions driven by the complement cascade, such as Ultomiris for generalized myasthenia gravis and paroxysmal nocturnal hemoglobinuria. Operates through its Alexion Pharmaceuticals division.
- Ultomiris - A long-acting C5 complement inhibitor.
- Strensiq - Treats hypophosphatasia, a rare metabolic disorder.
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Respiratory & Immunology (R&I) - Develops therapies for respiratory diseases and immune system disorders, including Symbicort for asthma and COPD, and Tezspire for severe asthma.
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Vaccines & Immune Therapies (V&I) - Focuses on vaccines and treatments for infectious diseases, including Beyfortus for respiratory syncytial virus (RSV) and Synagis for pediatric RSV prevention.
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Other Medicines - Includes legacy products such as Nexium for acid reflux and other established medicines.
| Name | Position | External Roles | Short Bio | |
|---|---|---|---|---|
Aradhana Sarin ExecutiveBoard | CFO and Executive Director | Board Member of the American Red Cross; Independent Director of Anheuser-Busch InBev. | CFO since 2021, previously CFO at Alexion; trained as a medical doctor and holds an MBA from Stanford. | |
Pascal Soriot ExecutiveBoard | CEO and Executive Director | Board Member of the Sustainable Markets Initiative Limited. | CEO since 2012, led AZN's growth, including R&D advancements and COVID-19 response; knighted in 2022. | |
David Fredrickson Executive | EVP, Oncology Business Unit | None. | EVP since 2017, led oncology portfolio growth, including Tagrisso and Imfinzi. | |
Iskra Reic Executive | EVP, International | Board Member of myTomorrows; Steering Committee Member of PHSSR. | EVP since 2024, previously led Vaccines & Immune Therapies; drives growth in Emerging Markets. | |
Jeff Pott Executive | Chief HR Officer, Chief Compliance Officer, and General Counsel | None. | Joined AZN in 1995; oversees HR, compliance, and legal functions. | |
Leon Wang Executive | EVP, International and China President | None. | EVP since 2017, led AZN's growth in China and Emerging Markets; established Shanghai R&D center. | |
Marc Dunoyer Executive | CEO of Alexion, AstraZeneca Rare Disease; Chief Strategy Officer | None. | CEO of Alexion since 2021; led integration of Alexion into AZN and expanded rare disease pipeline. | |
Pam Cheng Executive | EVP, Global Operations and IT; Chief Sustainability Officer | None. | EVP since 2015, leads sustainability strategy; recognized on TIME100 Climate list. | |
Ruud Dobber Executive | EVP, BioPharmaceuticals Business Unit | None. | EVP since 2019, responsible for CVRM, R&I, and neuroscience; key driver of product growth like Farxiga. | |
Sharon Barr Executive | EVP, BioPharmaceuticals R&D | None. | EVP since 2023, previously SVP at Alexion; oversees CVRM and R&I R&D. | |
Susan Galbraith Executive | EVP, Oncology R&D | None. | EVP since 2020, oversees oncology R&D; key contributor to Imfinzi and capivasertib development. | |
Andreas Rummelt Board | Non-Executive Director | Chair and Managing Partner of InterPharmaLink AG. | Director since 2021, former CEO of Sandoz and Novartis executive; extensive experience in generics and pharma. | |
Deborah DiSanzo Board | Non-Executive Director | President of Best Buy Health; teaches AI in Health at Harvard. | Director since 2017, over 30 years of experience in healthcare and technology; former GM of IBM Watson Health. | |
Diana Layfield Board | Non-Executive Director | Chair of British International Investment; Council Member of LSHTM. | Director since 2020, extensive global business experience; currently General Manager, International Search at Google. | |
Marcus Wallenberg Board | Non-Executive Director | Chair of SEB, Saab, and FAM AB; Vice-Chair of Investor AB and EQT AB. | Director since 1999, extensive international business experience across multiple industries. | |
Michel Demar\u00e9 Board | Non-Executive Chair of the Board | Non-Executive Director at Vodafone Group plc and Louis Dreyfus International; Chair of IMD. | Chair since 2023, previously Non-Executive Director; extensive experience in finance and governance. | |
Nazneen Rahman Board | Non-Executive Director | CEO of YewMaker; Director of Sustainable Medicines Partnership. | Director since 2017, expert in rare diseases and sustainable healthcare; former Professor of Genetics at ICR. | |
Philip Broadley Board | Senior Independent Non-Executive Director | Chair-designate of Lancashire Holdings; Senior Independent Director of Legal & General. | Director since 2017, extensive finance experience; previously Group Finance Director at Prudential and Old Mutual. | |
Sheri McCoy Board | Non-Executive Director | Chair of Dechra Pharmaceuticals; Board Member at Stryker, Kimberly-Clark, and Sail Biomedicines. | Director since 2017, former CEO of Avon and Vice-Chairman at J&J; extensive leadership in pharma and consumer health. | |
Tony Mok Board | Non-Executive Director | Non-Executive Director of HUTCHMED; Member of Prenetics Scientific Advisory Board. | Director since 2019, leading oncologist and researcher; Chair of Clinical Oncology at CUHK. |
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You have set a goal to reach mid-30s operating margins by 2026, but ended 2024 just above 31%, with guidance suggesting minimal leverage in 2025. How do you plan to achieve the remaining 400 basis points improvement in such a short timeframe?
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Airsupra was anticipated to be a multi-blockbuster drug, yet its launch has been relatively soft with little improvement in the fourth quarter. What strategies are you implementing to accelerate its growth and overcome the access challenges you've faced?
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Given the investigations and market pressures in China, including anticipated VBP inclusion for key products, how confident are you in your 2025 growth projections for the Chinese market, and what risks should investors be aware of?
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Can you discuss the potential financial impact of the customs duty issue in China, and clarify whether there is a risk of significant fines or liabilities that could affect your financial results?
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With the upcoming Part D redesign in 2025 affecting products like Calquence, how do you plan to mitigate the impact on your oncology portfolio and maintain the growth trajectory amid these legislative headwinds?
Notable M&A activity and strategic investments in the past 3 years.
| Company | Year | Details |
|---|---|---|
Gracell Biotechnologies, Inc. | 2024 | AstraZeneca acquired Gracell for an upfront cash payment of about $1.0 billion, with a total transaction value of approximately $1.2 billion that included additional contingent value; the deal brought in the clinical-stage FasTCAR-enabled BCMA/CD19 dual-targeting CAR‑T therapy (GC012F) along with $209 million in cash equivalents, strengthening its cell therapy pipeline. |
Icosavax, Inc. | 2024 | The acquisition was executed via a tender offer at $15.00 per share cash upfront plus a contingent value right up to $5.00 per share for a total potential value of around $1.1 billion; it bolsters AstraZeneca’s Vaccines & Immune Therapies portfolio with Icosavax’s Phase III-ready VLP vaccine candidate IVX-A12 targeting RSV and hMPV. |
Fusion Pharmaceuticals Inc. | 2024 | Completed for approximately $2.4 billion—$2.051 billion upfront and $144 million in contingent regulatory milestone payments—this deal adds next-generation radioconjugates (notably FPI-2265) to AstraZeneca’s oncology pipeline and accelerates its radiopharmaceutical manufacturing capabilities. |
Amolyt Pharma | 2024 | AstraZeneca acquired Amolyt Pharma for a total consideration of up to $1.05 billion (with $800 million upfront and up to $250 million contingent on milestones) to enhance its Rare Disease pipeline and expand its bone metabolism franchise with the Phase III candidate eneboparatide (AZP‑3601) for hypoparathyroidism. |
CinCor Pharma, Inc. | 2023 | The acquisition was structured as a tender offer with an upfront cash payment of about $1.3 billion (at $26 per share plus a $10 contingent per share), totaling approximately $1.8 billion, and included cash/marketable securities valued at $522 million; it adds the aldosterone synthase inhibitor baxdrostat (CIN‑107) to complement its cardiorenal strategy. |
Neogene Therapeutics, Inc. | 2023 | Completed for a total consideration of up to $320 million (with an initial $200 million cash payment and up to $120 million in contingent payments), the acquisition advances AstraZeneca’s cell therapy portfolio by adding next‑generation T‑cell receptor therapies targeting solid tumors along with significant intangible assets and goodwill. |
TeneoTwo, Inc. | 2022 | AstraZeneca acquired TeneoTwo, paying $100 million upfront and agreeing to up to $1.165 billion in milestone payments (combining R&D and commercial milestones), to secure its Phase I CD19/CD3 T‑cell engager TNB‑486 which is aimed at treating B‑cell hematologic malignancies without including transfer of people or facilities. |
No recent press releases or 8-K filings found for AZN.