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Perceptive Advisors LLC
Perceptive Advisors LLC is a New York-based hedge fund and investment adviser specializing in the healthcare and life sciences sectors. Founded in 1999, the firm manages approximately $8.5 billion in assets and employs around 45 people, primarily investors. Perceptive Advisors serves institutional and sophisticated investors seeking growth and innovation in biotechnology, pharmaceuticals, and medical technologies.
Investment Strategy
Perceptive Advisors focuses on identifying and investing in opportunities across the healthcare and life sciences industries, including biotechnology, pharmaceuticals, medical devices, diagnostics, and related sectors. The firm employs a fundamental, research-driven investment process, emphasizing deep industry knowledge and scientific expertise to discover undervalued companies with significant growth potential. Perceptive Advisors invests across both public and private markets and seeks to generate superior risk-adjusted returns through rigorous due diligence and active portfolio management.
Latest 13F Filing Activity
Perceptive Advisors LLC filed their most recent 13F report on Jun 30, 2025 disclosing 78 equity positions and 3 options positions with a total 13F market value of $3B. The fund increased holdings in Ascendis Pharma A/s, Verona Pharma PLC, Omada Health Inc. among other positions. Perceptive Advisors LLC reduced exposure to Amicus Therapeutics Inc., Intra-cellular Therapies Inc., Edgewise Therapeutics Inc. among others.
Top Holdings
Equity Positions (78)
| Ticker | Security | Weight | Market Value | Shares | Avg Cost | Price | Change (QoQ) |
|---|---|---|---|---|---|---|---|
V VRNA | VERONA PHARMA PLC | 19.31% | $520.9M | 5,507,591 | $23.99 | $94.58 | +$104.2M |
A ASND | ASCENDIS PHARMA A/S | 6.17% | $166.4M | 963,886 | $172.60 | $172.60 | +$166.4M |
A ACLX | ARCELLX INC | 6.05% | $163.2M | 2,478,000 | $27.37 | $65.85 | -$28.8M |
R RYTM | RHYTHM PHARMACEUTICALS INC | 5.67% | $152.8M | 2,418,299 | $42.95 | $63.19 | +$17.8M |
N NUVL | NUVALENT INC | 3.89% | $104.9M | 1,375,180 | $41.68 | $76.30 | -$11.0M |
Options Positions (3)
| Ticker | Security | Action | Type | Notional Value | Contracts | Underlying Price | Premium Paid | Change (Contracts) | Change (Value) |
|---|---|---|---|---|---|---|---|---|---|
X XBI | SPDR SERIES TRUST | New | Put | $24.9M | 3,000 | $82.93 | $82.93 | +3,000 | +$24.9M |
C CAPR | CAPRICOR THERAPEUTICS INC | New | Put | $6.5M | 6,500 | $9.93 | $9.93 | +6,500 | +$6.5M |
C CAPR | CAPRICOR THERAPEUTICS INC | New | Call | $993.0K | 1,000 | $9.93 | $9.93 | +1,000 | +$993.0K |
Industry Allocation
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