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Perceptive Advisors LLC

CIK:0001224962
Hedge Fund
$9B AUM
85 holdings
New York, NY, United States
Founded:1999
45 employees
Latest filing:Jun 30, 2025

Perceptive Advisors LLC is a New York-based hedge fund and investment adviser specializing in the healthcare and life sciences sectors. Founded in 1999, the firm manages approximately $8.5 billion in assets and employs around 45 people, primarily investors. Perceptive Advisors serves institutional and sophisticated investors seeking growth and innovation in biotechnology, pharmaceuticals, and medical technologies.

Investment Strategy

Perceptive Advisors focuses on identifying and investing in opportunities across the healthcare and life sciences industries, including biotechnology, pharmaceuticals, medical devices, diagnostics, and related sectors. The firm employs a fundamental, research-driven investment process, emphasizing deep industry knowledge and scientific expertise to discover undervalued companies with significant growth potential. Perceptive Advisors invests across both public and private markets and seeks to generate superior risk-adjusted returns through rigorous due diligence and active portfolio management.

Top Buys
A
ASNDASCENDIS PHARMA A/S
+$166.4M
V
VRNAVERONA PHARMA PLC
+$104.2M
O
OMDAOMADA HEALTH INC
+$44.4M
R
ROIVROIVANT SCIENCES LTD
+$37.5M
C
CAICARIS LIFE SCIENCES INC
+$29.3M
Top Sells
F
FOLDAMICUS THERAPEUTICS INC
-$132.7M
I
ITCIINTRA-CELLULAR THERAPIES INC
-$103.7M
E
EWTXEDGEWISE THERAPEUTICS INC
-$83.2M
S
SLNOSOLENO THERAPEUTICS INC
-$71.6M
I
IOVAIOVANCE BIOTHERAPEUTICS INC
-$42.3M

Top Holdings

V
VRNAVERONA PHARMA PLC
+19.3%$520.9M
A
ASNDASCENDIS PHARMA A/S
+6.2%$166.4M
A
ACLXARCELLX INC
+6.0%$163.2M
R
RYTMRHYTHM PHARMACEUTICALS INC
+5.7%$152.8M
N
NUVLNUVALENT INC
+3.9%$104.9M

Equity Positions (78)

TickerSecurityWeightMarket ValueSharesAvg CostPriceChange (QoQ)
V
VRNA
VERONA PHARMA PLC19.31%$520.9M5,507,591$23.99$94.58+$104.2M
A
ASND
ASCENDIS PHARMA A/S6.17%$166.4M963,886$172.60$172.60+$166.4M
A
ACLX
ARCELLX INC6.05%$163.2M2,478,000$27.37$65.85-$28.8M
R
RYTM
RHYTHM PHARMACEUTICALS INC5.67%$152.8M2,418,299$42.95$63.19+$17.8M
N
NUVL
NUVALENT INC3.89%$104.9M1,375,180$41.68$76.30-$11.0M

Options Positions (3)

TickerSecurityActionTypeNotional ValueContractsUnderlying PricePremium PaidChange (Contracts)Change (Value)
X
XBI
SPDR SERIES TRUSTNew
Put
$24.9M3,000$82.93$82.93+3,000+$24.9M
C
CAPR
CAPRICOR THERAPEUTICS INCNew
Put
$6.5M6,500$9.93$9.93+6,500+$6.5M
C
CAPR
CAPRICOR THERAPEUTICS INCNew
Call
$993.0K1,000$9.93$9.93+1,000+$993.0K

Industry Allocation

PHARMACEUTICAL PREPARATIONS
+63.7%
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
+21.0%
SURGICAL & MEDICAL INSTRUMENTS & APPARATUS
+4.4%
SERVICES-MEDICAL LABORATORIES
+2.2%
ELECTROMEDICAL & ELECTROTHERAPEUTIC APPARATUS
+1.9%