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5am Venture Management, LLC
5AM Ventures is a leading investment firm focused on funding and building next-generation life sciences companies.
Investment Strategy
Invests primarily in early-stage biopharmaceutical companies with a focus on Series A investments and small to mid-cap public and private biotech companies.
Latest 13F Filing Activity
5am Venture Management, LLC filed their most recent 13F report on Jun 30, 2025 disclosing 29 equity positions with a total 13F market value of $260M. The fund increased holdings in Skye Bioscience Inc., Vor Biopharma Inc., Eyepoint Pharmaceuticals Inc. among other positions. 5am Venture Management, LLC reduced exposure to Entrada Therapeutics Inc., Enliven Therapeutics Inc., Camp4 Therapeutics Corp. among others.
Top Holdings
Equity Positions (29)
| Ticker | Security | Weight | Market Value | Shares | Avg Cost | Price | Change (QoQ) |
|---|---|---|---|---|---|---|---|
S SKYE | SKYE BIOSCIENCE INC | 15.93% | $41.4M | 9,913,168 | $8.06 | $4.18 | +$25.7M |
T TRDA | ENTRADA THERAPEUTICS INC | 11.13% | $29.0M | 4,308,379 | $17.12 | $6.72 | -$10.9M |
D DNTH | DIANTHUS THERAPEUTICS INC | 7.05% | $18.3M | 984,725 | $13.67 | $18.63 | -$297.3K |
E ELVN | ENLIVEN THERAPEUTICS INC | 5.96% | $15.5M | 772,477 | $21.90 | $20.06 | -$10.5M |
P PHVS | PHARVARIS N V | 5.40% | $14.0M | 797,600 | $23.67 | $17.60 | +$1.5M |
Industry Allocation
Investment Team (6)
| Name | Role | Location | |
|---|---|---|---|
 | Analyst | San Francisco, CA , United States | |
 | Partner | Los Angeles, CA , United States | |
 | Senior Research Analyst | Boston, MA , United States | |
K Katie Bodner | Analyst | Boston, MA , United States | |
 | Managing Partner | Boston, MA , United States | |
 | Principal | CA , United States |
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