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BridgeBio Pharma (BBIO)

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Earnings summaries and quarterly performance for BridgeBio Pharma.

Recent press releases and 8-K filings for BBIO.

BridgeBio Pharma Prices Convertible Senior Notes Offering
BBIO
Debt Issuance
Share Buyback
Convertible Preferred Issuance
  • BridgeBio Pharma priced an offering of $550 million aggregate principal amount of 0.75% convertible senior notes due 2033.
  • This offering is part of the company's strategy to lower interest expense, reduce dilution, and significantly extend debt maturity.
  • The notes bear an interest rate of 0.75% and have an initial conversion price representing a 45% premium over the last reported stock price on January 15, 2026.
  • The net proceeds will be used to repurchase, settle future conversion obligations in respect of, or repay at maturity a portion of the company’s 2.50% convertible senior notes due 2027 and for general corporate purposes.
  • BridgeBio also intends to use approximately $82.5 million of cash on hand to repurchase approximately 1.1 million shares of its common stock.
2 days ago
BridgeBio Pharma Announces Proposed Offering of Convertible Senior Notes due 2033
BBIO
Debt Issuance
Share Buyback
  • BridgeBio Pharma intends to offer $550 million aggregate principal amount of convertible senior notes due 2033 in a private offering, with an option for initial purchasers to purchase up to an additional $82.5 million.
  • The net proceeds from this offering are intended to repurchase, settle, or repay a portion of the company's 2.50% convertible senior notes due 2027 and for general corporate purposes.
  • Concurrently with the pricing of the new notes, BridgeBio plans to use up to $82.5 million of cash on hand to repurchase shares of its common stock from certain purchasers of the notes.
  • The new notes will mature on February 1, 2033, bear interest semi-annually, and will be senior unsecured obligations.
4 days ago
BridgeBio Pharma Announces Q4 and Full Year 2025 Preliminary Revenue and 2026 Milestones
BBIO
Earnings
Guidance Update
New Projects/Investments
  • BridgeBio announced preliminary unaudited net product revenue for Attruby of $146.0 million for Q4 2025 and $362.4 million for Full Year 2025.
  • As of December 31, 2025, the company had approximately $587.5 million in cash, cash equivalents, and marketable securities.
  • Attruby achieved 6,629 unique patient prescriptions from 1,632 prescribers as of December 31, 2025.
  • BridgeBio intends to submit New Drug Applications (NDAs) in the first half of 2026 for BBP-418 (LGMD2I/R9) and encaleret (ADH1).
  • Topline results for the PROPEL 3 Phase 3 study of infigratinib for achondroplasia are expected by the end of Q1 2026.
6 days ago
BridgeBio Pharma and Xenon Pharmaceuticals Provide Clinical Program Updates at J.P. Morgan Conference
BBIO
New Projects/Investments
Product Launch
  • BridgeBio Pharma announced plans to file an NDA for its LGMD2i treatment mid-year, following observed statistically significant improvements in ambulation and breathing in clinical data.
  • BridgeBio Pharma also reported positive Phase III results for encaleret in ADH1, demonstrating a 76% responder rate and normalization of calcium levels, with efforts underway to identify 3,000-5,000 potential patients.
  • Xenon Pharmaceuticals is anticipating the readout of its X-TOLE2 Phase III study for azetukalner in focal onset seizures in March of this year, having previously shown over 90% reduction in seizure burden and nearly 40% of patients achieving 12 months of seizure freedom in open-label extension data.
  • Xenon Pharmaceuticals provided an update on its early-stage pipeline, with its lead Nav1.7 molecule, XEN1701, in a Phase I trial for pain, showing exposures predicted to mimic human genetics, and a proof of concept study expected before the end of 2026.
6 days ago
BridgeBio Reports Q4 2025 Attruby Revenue and Year-End Cash, Highlights Pipeline Progress
BBIO
Earnings
Product Launch
New Projects/Investments
  • BridgeBio reported $146 million in Attruby net product revenue for Q4 2025, with 6,629 unique U.S. patient prescriptions and an estimated >25% new-to-brand prescription share as of December 31, 2025.
  • The company concluded 2025 with $587.5 million in cash, cash equivalents, and marketable securities, noting a decline in cash burn in Q4 2025 compared to Q3 2025.
  • Key pipeline advancements include a new antibody depleter program for ATTR-CM, anticipated NDA filings for encaleret and BBP-418 in 1H 2026 with potential FDA approvals and launches in 1H 2027, and positive Phase 2a data for PORT-77 in Erythropoietic Protoporphyria (EPP).
6 days ago
BridgeBio and Xenon Pharmaceuticals Provide Business and Clinical Updates
BBIO
Revenue Acceleration/Inflection
Guidance Update
New Projects/Investments
  • BridgeBio preannounced Q4 revenue of $146 million, representing 35% growth over the last quarter, with total first-year launch revenue reaching $362 million. The Attruby franchise is projected to exceed $1 billion in revenue in 2026.
  • BridgeBio anticipates Phase 3 data readout for achondroplasia in Q1 2026 and reported positive Phase 2A results for its EPP program (Port77), demonstrating a 75% reduction in PP9 levels in plasma.
  • Xenon Pharmaceuticals expects its first Phase 3 clinical data readout for azetukalner in focal onset seizures (X-TOLE 2) in March 2026 , following Phase 2b data that showed a 52.8% reduction in seizures.
  • Xenon also projects Phase 3 data for azetukalner in major depressive disorder (X-NOVA 2) in the first half of 2027 and plans a proof-of-concept study for its early-stage Nav1.7 program (XEN1701) before the end of 2026.
6 days ago
BridgeBio Pharma Provides Update on Infigratinib Clinical Development and Market Opportunity
BBIO
Product Launch
New Projects/Investments
  • BridgeBio Pharma (BBIO) expects top-line results for its pivotal Phase 3 PROPEL 3 study of oral infigratinib for achondroplasia in Q1 2026.
  • The Phase 2 PROPEL 2 study demonstrated a 2.5 cm/year increase in annualized height velocity at 12 and 18 months (p=0.0015) and statistically significant improvement in body proportions at 18 months (p=0.001), with the drug being well tolerated.
  • Infigratinib has received Breakthrough Therapy Designation from the FDA and is positioned as the first oral treatment option for achondroplasia, addressing a global market opportunity of over $5 billion.
  • Market research indicates a projected over 50% market share in a three-way market, with oral administration being the strongest driver for switching from current injectable therapies.
  • Safety expectations for the Phase 3 readout include no symptomatic hypotension or injection site reactions and a hyperphosphatemia rate of less than 10%.
Jan 9, 2026, 1:00 PM
BridgeBio Pharma Provides Update on Infigratinib Clinical Development and Market Opportunity
BBIO
New Projects/Investments
Product Launch
  • BridgeBio Pharma's infigratinib program is positioned as a potentially best-in-class oral treatment for achondroplasia, designed to target FGFR3 overactivation.
  • The global market opportunity for achondroplasia is estimated at $5 billion, with market research indicating infigratinib could capture over 50% of the treated market share, primarily driven by its favorable oral administration and mechanism of action.
  • Topline results for the PROPEL 3 study are expected in Q1 2026, with regulatory interactions planned for 2026, supported by its FDA Breakthrough Designation.
  • Enrollment for the Phase 2 portion of the ACCEL 2/3 study in hypochondroplasia is complete, with proof-of-concept results anticipated in 2H 2026.
Jan 9, 2026, 1:00 PM
BridgeBio Pharma Provides Update on Achondroplasia Program
BBIO
Product Launch
New Projects/Investments
  • BridgeBio Pharma's PROPEL 3 phase three clinical trial for infigratinib in achondroplasia has achieved last participant last visit, with top-line results expected by the end of the first quarter.
  • Infigratinib is positioned as a potential best-in-class oral treatment option for achondroplasia, targeting a global market opportunity of over $5 billion for more than 55,000 individuals with open growth plates.
  • Physician surveys indicate a strong preference for an oral FGFR3 inhibitor, with 94% of respondents citing oral administration as a compelling reason to switch from current therapies.
  • The PROPEL 3 trial is a double-blind placebo-controlled study evaluating infigratinib in children aged three to 18 years, with a separate study ongoing for infants and toddlers (birth to three years of age).
Jan 9, 2026, 1:00 PM
BridgeBio Pharma Provides Update on Infigratinib Achondroplasia Program
BBIO
New Projects/Investments
Product Launch
  • BridgeBio Pharma's Infigratinib program for achondroplasia has achieved last participant last visit for its Phase 3 PROPEL 3 clinical trial, with top-line results expected by the end of Q1.
  • Infigratinib is an oral, first-in-class FGFR123 tyrosine kinase inhibitor that targets the precise source of achondroplasia, offering a significant advantage over injectable treatments by avoiding issues like injection site reactions and psychosocial burden.
  • Results from the Phase 2 PROPEL 2 study demonstrated robust increases in annualized height velocity (2.5 cm/year) and statistically significant improvement in body proportionality, with the drug being well tolerated and no safety concerns identified.
  • Market research indicates a strong physician and patient preference for an oral treatment, with 94% of surveyed healthcare professionals citing the ability to avoid injections as a compelling reason to switch from current therapies.
  • The global market opportunity for achondroplasia in individuals with open growth plates is estimated at over $5 billion, with only about 10% of these individuals currently on a treatment option, highlighting the significant unmet need for an oral therapeutic.
Jan 9, 2026, 1:00 PM