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Exome Asset Management LLC
Exome Asset Management LLC is a New York-based investment advisory firm founded in 2018 by Samuel D. Isaly. The firm is headed by Isaly as Managing Partner and operates with a staff of approximately 9-10 employees. Exome specializes in serving pooled investment vehicles, focusing on sectors such as healthcare and biotechnology. The firm is registered with the SEC and targets institutional and professional investors with sector-specific strategies.
Investment Strategy
Exome Asset Management LLC utilizes a sector-focused investment strategy, primarily targeting equities and related securities within the healthcare and biotechnology sectors. The firm manages assets through pooled investment vehicles, employing both discretionary and research-driven approaches to identify compelling opportunities in rapidly evolving markets. Exome’s philosophy emphasizes fundamental analysis, portfolio diversification, and risk management tailored to the dynamics of life sciences, pharmaceuticals, and biotechnology industries.
Latest 13F Filing Activity
Exome Asset Management LLC filed their most recent 13F report on Jun 30, 2025 disclosing 28 equity positions and 3 options positions with a total 13F market value of $158M. The fund increased holdings in Verastem Inc., Acadia Pharmaceuticals Inc., Waystar HLDG Corp. among other positions. Exome Asset Management LLC reduced exposure to Viridian Therapeutics Inc., Savara Inc., Ge Healthcare Technologies I among others.
Top Holdings
Equity Positions (28)
| Ticker | Security | Weight | Market Value | Shares | Avg Cost | Price | Change (QoQ) |
|---|---|---|---|---|---|---|---|
B BBIO | BRIDGEBIO PHARMA INC | 4.25% | $6.7M | 155,533 | $28.66 | $43.18 | +$994.7K |
G GH | GUARDANT HEALTH INC | 3.23% | $5.1M | 98,182 | $24.49 | $52.04 | -$308.6K |
G GERN | GERON CORP | 3.04% | $4.8M | 3,414,377 | $2.74 | $1.41 | -$298.3K |
I IONS | IONIS PHARMACEUTICALS INC | 3.02% | $4.8M | 121,116 | $32.34 | $39.51 | +$693.8K |
A AZN | ASTRAZENECA PLC | 2.49% | $3.9M | 28,362 | $73.50 | $69.88 | -$792.7K |
Options Positions (3)
Industry Allocation
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