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Exome Asset Management LLC

CIK:0002011932
Hedge Fund
$211M AUM
73 holdings
New York, NY, United States
Founded:2018
10 employees
Latest filing:Jun 30, 2025

Exome Asset Management LLC is a New York-based investment advisory firm founded in 2018 by Samuel D. Isaly. The firm is headed by Isaly as Managing Partner and operates with a staff of approximately 9-10 employees. Exome specializes in serving pooled investment vehicles, focusing on sectors such as healthcare and biotechnology. The firm is registered with the SEC and targets institutional and professional investors with sector-specific strategies.

Investment Strategy

Exome Asset Management LLC utilizes a sector-focused investment strategy, primarily targeting equities and related securities within the healthcare and biotechnology sectors. The firm manages assets through pooled investment vehicles, employing both discretionary and research-driven approaches to identify compelling opportunities in rapidly evolving markets. Exome’s philosophy emphasizes fundamental analysis, portfolio diversification, and risk management tailored to the dynamics of life sciences, pharmaceuticals, and biotechnology industries.

Top Buys
V
VSTMVERASTEM INC
+$2.5M
A
ACADACADIA PHARMACEUTICALS INC
+$2.0M
W
WAYWAYSTAR HLDG CORP
+$1.9M
U
UHSUNIVERSAL HLTH SVCS INC
+$1.8M
A
ABCCENCORA INC
+$1.8M
Top Sells
V
VRDNVIRIDIAN THERAPEUTICS INC
-$2.9M
S
SVRASAVARA INC
-$2.3M
G
GEHCGE HEALTHCARE TECHNOLOGIES I
-$2.1M
A
ANABANAPTYSBIO INC
-$1.8M
I
IMNMIMMUNOME INC
-$1.8M

Top Holdings

B
BBIOBRIDGEBIO PHARMA INC
+4.2%$6.7M
G
GHGUARDANT HEALTH INC
+3.2%$5.1M
G
GERNGERON CORP
+3.0%$4.8M
I
IONSIONIS PHARMACEUTICALS INC
+3.0%$4.8M
A
AZNASTRAZENECA PLC
+2.5%$3.9M

Equity Positions (28)

TickerSecurityWeightMarket ValueSharesAvg CostPriceChange (QoQ)
B
BBIO
BRIDGEBIO PHARMA INC4.25%$6.7M155,533$28.66$43.18+$994.7K
G
GH
GUARDANT HEALTH INC3.23%$5.1M98,182$24.49$52.04-$308.6K
G
GERN
GERON CORP3.04%$4.8M3,414,377$2.74$1.41-$298.3K
I
IONS
IONIS PHARMACEUTICALS INC3.02%$4.8M121,116$32.34$39.51+$693.8K
A
AZN
ASTRAZENECA PLC2.49%$3.9M28,362$73.50$69.88-$792.7K

Options Positions (3)

TickerSecurityActionTypeNotional ValueContractsUnderlying PricePremium PaidChange (Contracts)Change (Value)
A
AZN
ASTRAZENECA PLCNew
Put
$3.9M284$69.88$69.88+283.62+$3.9M
A
ACAD
ACADIA PHARMACEUTICALS INCNew
Call
$2.0M932$21.57$21.57+932.22+$2.0M
A
ABC
CENCORA INCNew
Call
$1.8M60$187.22$187.22+60+$1.8M

Industry Allocation

PHARMACEUTICAL PREPARATIONS
+35.3%
SERVICES-MEDICAL LABORATORIES
+5.2%
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
+3.1%
WHOLESALE-DRUGS, PROPRIETARIES & DRUGGISTS' SUNDRIES
+2.3%
BLANK CHECKS
+2.1%