Earnings summaries and quarterly performance for Verastem.
Executive leadership at Verastem.
Board of directors at Verastem.
Research analysts who have asked questions during Verastem earnings calls.
AN
Anish Nikhanj
RBC Capital Markets
1 question for VSTM
Also covers: APTO, CRMD, EXEL +6 more
A
Anshi
Jefferies
1 question for VSTM
Graig Suvannavejh
Mizuho Securities
1 question for VSTM
Also covers: ADAP, ADVM, ALEC +11 more
James Molloy
Alliance Global Partners
1 question for VSTM
Also covers: ABEO, ACXP, AIM +11 more
Justin Zelin
BTIG, LLC
1 question for VSTM
Also covers: BCAB, CASI, GLMD +9 more
KH
Kelly Hsu
Jefferies
1 question for VSTM
Leonid Timashev
RBC Capital Markets
1 question for VSTM
Also covers: ADCT, ALKS, AXSM +8 more
Michael Schmidt
Guggenheim Securities
1 question for VSTM
Also covers: ADAP, ADCT, ARVN +19 more
Paul Jeng
Guggenheim Partners
1 question for VSTM
Also covers: ADAP, BPMC, IMCR +2 more
PS
Pete Stavropoulos
Cantor Fitzgerald
1 question for VSTM
Also covers: ABOS, ALEC, ARCT +7 more
Sean Lee
H.C. Wainwright & Co.
1 question for VSTM
Also covers: ATEC, CASI, CTSO +2 more
YZ
Yuan Zhi
B. Riley Financial, Inc.
1 question for VSTM
Also covers: HYPR, LNTH, MIR +4 more
Recent press releases and 8-K filings for VSTM.
Verastem Oncology Provides Preliminary Q4 and Full Year 2025 Revenue and Business Updates
VSTM
Earnings
Product Launch
Guidance Update
- Verastem Oncology reported preliminary, unaudited net product revenues for AVMAPKI FAKZYNJA CO-PACK of approximately $17.5 million for the fourth quarter of 2025 and approximately $30.9 million for the full year 2025, following its U.S. FDA approval in May 2025.
- As of December 31, 2025, the company had preliminary unaudited cash, cash equivalents, and investments of $205 million, with a pro-forma total of $234 million including proceeds from warrant exercises, projecting a cash runway into the first half of 2027.
- For 2026, Verastem plans to maximize adoption of AVMAPKI FAKZYNJA CO-PACK in the U.S. and accelerate the clinical path for VS-7375, its oral KRAS G12D inhibitor, with potential registration-directed clinical trials.
- The company anticipates the LGSOC commercial launch and development program for AVMAPKI FAKZYNJA CO-PACK to be self-sustaining by the second half of 2026.
1 day ago
Verastem Oncology Reports Preliminary 2025 Financials and Outlines 2026 Strategic Priorities
VSTM
Earnings
Guidance Update
Product Launch
- Verastem Oncology reported preliminary, unaudited net product revenues for AVMAPKI FAKZYNJA CO-PACK of approximately $17.5 million for the fourth quarter of 2025 and $30.9 million for the full year 2025.
- As of December 31, 2025, the company had $205 million in cash, cash equivalents, and investments, with a pro-forma $234 million including net proceeds from exercised cash warrants, providing a cash runway into the first half of 2027.
- The company's 2026 priorities include maximizing the commercial launch of AVMAPKI FAKZYNJA CO-PACK, which received U.S. FDA approval in May 2025 for KRAS-mutated recurrent LGSOC, and advancing its clinical development program for VS-7375, a KRAS G12D inhibitor.
- An interim update on the Phase 1/2 trial of VS-7375 is expected in 1H 2026, and a topline readout of the primary endpoint in the RAMP 301 trial is anticipated in mid-2027.
1 day ago
Verastem, Inc. Updates Corporate Presentation with Q3 2025 Financials and 2026 Priorities
VSTM
Product Launch
Guidance Update
New Projects/Investments
- Verastem, Inc. reported net product revenue of $11.2 million for Q3 2025, following the May 8, 2025, FDA approval and commercial launch of AVMAPKIFAKZYNJACO-PACK for KRAS mutant-type recurrent Low-Grade Serous Ovarian Cancer.
- The company ended Q3 2025 with $137.7 million in cash, cash equivalents, and short-term investments, with a pro-forma amount of $235.0 million, extending its cash runway into 1H 2027.
- Key priorities for 2026 include maximizing the commercial launch of AVMAPKIFAKZYNJACO-PACK, continuing the RAMP 301 confirmatory Phase 3 trial, and generating monotherapy and combination data with VS-7375 to inform its registration path.
- Upcoming milestones include an update on the RAMP 205 expansion cohort and an interim update for VS-7375 monotherapy in 1H 2026, with RAMP 301 topline data expected by mid-2027.
Jan 8, 2026, 9:16 PM
Verastem Discontinues RAMP-203 Trial, Pivots to VS-7375
VSTM
New Projects/Investments
Insider Selling
Demand Weakening
- Verastem Oncology is discontinuing the RAMP-203 trial for advanced KRAS G12C-mutant non-small cell lung cancer, citing the emergence of next-generation G12C inhibitors with higher response rates.
- The company plans to reallocate resources to VS-7375, an oral KRAS G12D inhibitor, which has shown approximately a 69% response rate in advanced NSCLC.
- This announcement led to a 2% after-hours stock decline and comes amid clear financial strain, including large negative margins, an Altman Z-Score in the distress zone, and 12 insider selling transactions in the prior three months.
- Verastem's trailing-12-month revenue was about $13.38 million, with a market capitalization of roughly $584.5 million and a three-year revenue growth rate of about 25.7%.
Dec 29, 2025, 9:10 PM
Verastem Oncology Discontinues RAMP 203 Trial, Prioritizes Other Programs
VSTM
New Projects/Investments
Product Launch
- Verastem Oncology will discontinue the RAMP 203 Phase 1/2 clinical trial for advanced KRAS G12C-mutated non-small cell lung cancer (NSCLC) to strategically prioritize resources on the clinical development of VS-7375 and the RAMP 205 trial.
- The decision to discontinue RAMP 203 was made following an evaluation of interim data as of November 26, 2025, and reflects the evolving treatment landscape for KRAS G12C inhibitors.
- The company is prioritizing VS-7375, an oral KRAS G12D (ON/OFF) inhibitor, which demonstrated a 69% response rate (11 of 16) in advanced KRAS G12D NSCLC.
- Interim data from RAMP 203 showed that for G12C-inhibitor treatment-naïve patients in the doublet combination, the overall response rate was 40% (12/30) and the median progression-free survival was 11.1 months.
- Separately, the FDA approved AVMAPKI FAKZYNJA CO-PACK on May 8, 2025, for the treatment of adult patients with KRAS-mutated recurrent low-grade serous ovarian cancer.
Dec 29, 2025, 9:01 PM
Verastem Announces Strategic Leadership Changes and COO Departure
VSTM
Board Change
Management Change
Executive Compensation
- Verastem Oncology announced strategic leadership changes, appointing John Johnson as Chairman of the Board and Michael Kauffman, M.D., Ph.D., as President of Development.
- Matthew Ros, Chief Operating Officer, departed the company effective December 19, 2025, as part of an operational streamlining.
- In connection with his separation, Mr. Ros will receive nine months of base salary continuation totaling $363,750.00, COBRA premium payments for nine months, and a pro-rated bonus of $196,425.00 for 2025.
- The company completed additional patient enrollment for its RAMP 301 Phase 3 confirmatory trial in recurrent LGSOC, with topline data anticipated in mid-2027.
Dec 19, 2025, 10:21 PM
Verastem Oncology Announces Leadership Changes and Clinical Trial Progress
VSTM
Board Change
Management Change
Product Launch
- John Johnson has been appointed Chairman of the Board, succeeding Michael Kauffman, M.D., Ph.D., who will now serve as President of Development and join the executive leadership team.
- Matthew Ros, Chief Operating Officer, is departing the organization as part of an operational streamlining.
- The commercial launch of AVMAPKI FAKZYNJA CO-PACK is progressing, following its FDA approval on May 8, 2025, for KRAS-mutated recurrent LGSOC.
- The RAMP 301 Phase 3 confirmatory trial for recurrent LGSOC has completed additional patient enrollment, with topline data anticipated in mid-2027.
Dec 15, 2025, 9:01 PM
Verastem Discusses Avutometinib Launch and G12D Inhibitor Development Outlook
VSTM
Product Launch
New Projects/Investments
- Verastem is focused on the launch of avutometinib for low-grade serous ovarian cancer, noting that patients are switching to their drug upon progression or intolerability from current therapies.
- 2026 is anticipated to be a critical year for the company, balancing continued launch momentum with accelerated development of their G12D inhibitor.
- Initial results for the primary endpoint (PFS) from the RAMP 301 study are expected in the second half of 2027.
- Their G12D inhibitor has demonstrated strong efficacy in collaborator GenFleet's trials, with a 69% response rate in lung and 58% in second-line pancreatic at the recommended phase II dose, positioning it as potentially best-in-class.
- The company is actively pursuing combination therapies for its G12D inhibitor, including cetuximab for second-line colorectal and chemo/chemo-IO for lung, with a strategic focus on achieving frontline approval.
Dec 2, 2025, 3:25 PM
Verastem Provides Update on Avutometinib Launch and G12D Inhibitor Program
VSTM
Product Launch
New Projects/Investments
Guidance Update
- Verastem is advancing its small molecule pipeline targeting the RAS pathway, with avutometinib launched for low-grade serous ovarian cancer and a G12D inhibitor in development. The company expects 2026 to be a pivotal year for both the continued launch momentum and the acceleration of the G12D development program.
- The launch of avutometinib is seeing an expected NCCN guidance update in early 2026, which is anticipated to influence the launch trajectory. The RAMP 301 trial, after an interim analysis, added 29 patients to both wild type and mutant arms, with initial results (PFS) expected in the second half of 2027.
- Verastem's G12D inhibitor, through its collaborator GenFleet, has demonstrated high efficacy, reporting a 69% response rate in lung cancer and a 58% response rate in second-line pancreatic cancer at the recommended phase 2 dose. Verastem is implementing trial design elements like prophylactic antiemetics to address tolerability concerns observed in GenFleet's data.
- The company is actively developing combination therapies for its G12D inhibitor, including a Cetuximab combination for second-line colorectal cancer and exploring chemo/immuno-oncology combinations for lung cancer, with a strategic focus on achieving frontline approvals.
Dec 2, 2025, 3:25 PM
Verastem Provides Updates on Avutometinib Launch and KRAS G12D Program
VSTM
Product Launch
New Projects/Investments
Guidance Update
- Verastem is actively managing the launch of avutometinib for low-grade serous ovarian cancer, with expectations for continued progress in 2026 and efforts to tighten market consensus. The company anticipates an update to NCCN guidelines sometime after the first of the year, which could impact launch trajectory.
- The RAMP 301 trial for avutometinib, which added 29 patients based on IDMC recommendation, is expected to have initial results (PFS) in the second half of 2027.
- Verastem's G12D inhibitor shows promising efficacy, with collaborator GenFleet reporting a 69% response rate in lung and a 58% response rate in second-line pancreatic patients at the recommended phase two dose, which is considered best-in-class.
- For 2026, Verastem plans to maintain momentum for the avutometinib launch and accelerate the development program for its G12D asset, including a Cetuximab combination for colorectal cancer and chemo combinations for lung cancer.
Dec 2, 2025, 3:25 PM
Quarterly earnings call transcripts for Verastem.
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