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Sio Capital Management, LLC
Sio Capital Management, LLC is a SEC-registered investment advisor headquartered in New York, specializing as a healthcare-focused hedge fund. Founded in 2006 by Dr. Michael Castor, the firm manages equity strategies within the healthcare sector. Sio Capital is led by Dr. Castor, who serves as head portfolio manager, and the team serves institutional investors and qualified clients seeking exposure to global healthcare equities. The firm's size is boutique, with a limited number of employees focusing on market-neutral and long/short investment strategies within the healthcare space.
Investment Strategy
Sio Capital Management employs a global equity market neutral strategy focused exclusively on the healthcare sector. The firm seeks to generate alpha by taking both long and short positions in healthcare equities, aiming for market-neutral exposure. Their approach emphasizes fundamental research, risk management, and diversification across healthcare sub-industries, targeting consistent returns with controlled volatility regardless of broader market movement.
Latest 13F Filing Activity
Sio Capital Management, LLC filed their most recent 13F report on Jun 30, 2025 disclosing 46 equity positions and 2 options positions with a total 13F market value of $262M. The fund increased holdings in Centene Corp. Del, Disc Medicine Inc., Sanofi among other positions. Sio Capital Management, LLC reduced exposure to Icon PLC, Zimmer Biomet Holdings Inc., Labcorp Holdings Inc. among others.
Top Holdings
Equity Positions (46)
| Ticker | Security | Weight | Market Value | Shares | Avg Cost | Price | Change (QoQ) |
|---|---|---|---|---|---|---|---|
M MMS | MAXIMUS INC | 14.69% | $38.5M | 548,086 | $78.22 | $70.20 | +$6.5M |
I IRON | DISC MEDICINE INC | 5.76% | $15.1M | 284,787 | $51.28 | $52.96 | +$11.4M |
G GMED | GLOBUS MED INC | 5.54% | $14.5M | 245,570 | $70.97 | $59.02 | -$658.9K |
C CNC | CENTENE CORP DEL | 5.44% | $14.2M | 262,500 | $54.28 | $54.28 | +$14.2M |
M MRK | MERCK & CO INC | 5.26% | $13.8M | 173,951 | $89.76 | $79.16 | -$10.5M |
Options Positions (2)
Industry Allocation
Investment Team (9)
| Name | Role | Location | |
|---|---|---|---|
 | Analyst | New Haven, CT , United States | |
M Mansi Sanghvi | Principal | United States | |
 | Portfolio Manager and Managing Director | New York, NY , United States | |
 | Research Analyst | Edgewater, NJ , United States | |
E Eric Song | analyst | New York, NY , United States | |
 | Senior Research Analyst | Mississauga, ON , Canada | |
 | Analyst | Toronto, ON , Canada | |
U Usman Hassan | Analyst | New York, NY , United States | |
V Vladimir Vasilyev | Healthcare Analyst | New York, NY , United States |
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