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TCG Crossover Management, LLC

CIK:0001839948
Investment Adviser
$2B AUM
37 holdings
Palo Alto, CA, United States
Founded:2021
17 employees
Latest filing:Jun 30, 2025

TCG Crossover Management, LLC is a science-driven investment firm based in Palo Alto, California. Founded and led by Managing Partner Chen Yu, the firm specializes in investing in breakthrough and disruptive medicines. As an investment adviser registered with the SEC, it manages both public and private equity investments in the life sciences sector. The firm has approximately 17 employees, primarily investors, and operates with a global perspective while maintaining a core presence in the US and Europe. TCG Crossover Management serves institutional investors and high-net-worth individuals seeking exposure to innovation in healthcare and biotechnology.

Investment Strategy

TCG Crossover Management (TCGX) invests in transformative healthcare and biotechnology companies, with a focus on advancing disruptive and breakthrough medicines. The firm employs a science-driven and crossover investment approach, participating in both private and public markets. Their strategy targets early and late-stage companies with the potential for significant clinical or commercial impact, leveraging deep scientific and industry expertise to identify novel therapeutics and platforms. TCGX seeks to build concentrated portfolios, taking meaningful positions in companies they believe can deliver outsized returns through major advances in medicine.

Top Buys
T
TNGXTANGO THERAPEUTICS INC
+$40.3M
C
CDTXCIDARA THERAPEUTICS INC
+$27.3M
A
AGIOAgios Pharmaceuticals, Inc.
+$23.2M
F
FULCFULCRUM THERAPEUTICS INC
+$21.0M
A
AMLXAMYLYX PHARMACEUTICALS INC
+$17.1M
Top Sells
M
MLYSMINERALYS THERAPEUTICS INC
-$39.2M
R
RAPTRAPT Therapeutics, Inc.
-$16.0M
C
CMPSCOMPASS PATHWAYS LTD
-$11.0M
X
XNCRXENCOR INC
-$6.8M
S
SVRASAVARA INC
-$6.1M

Top Holdings

C
CGONCG ONCOLOGY INC
+10.9%$95.4M
T
TNGXTANGO THERAPEUTICS INC
+6.3%$55.0M
C
COGTCOGENT BIOSCIENCES INC
+5.7%$50.0M
O
OCULOCULAR THERAPEUTIX INC
+5.6%$49.4M
C
CDTXCIDARA THERAPEUTICS INC
+5.6%$49.0M

Equity Positions (37)

TickerSecurityWeightMarket ValueSharesAvg CostPriceChange (QoQ)
C
CGON
CG ONCOLOGY INC10.90%$95.4M3,670,206$42.46$26.00+$5.5M
T
TNGX
TANGO THERAPEUTICS INC6.28%$55.0M10,736,000$3.09$5.12+$40.3M
C
COGT
COGENT BIOSCIENCES INC5.71%$50.0M6,964,375$9.47$7.18+$8.3M
O
OCUL
OCULAR THERAPEUTIX INC5.64%$49.4M5,319,148$8.69$9.28+$10.4M
C
CDTX
CIDARA THERAPEUTICS INC5.60%$49.0M1,005,901$26.88$48.71+$27.3M

Industry Allocation

PHARMACEUTICAL PREPARATIONS
+74.2%
BIOLOGICAL PRODUCTS, (NO DIAGNOSTIC SUBSTANCES)
+20.1%
LABORATORY ANALYTICAL INSTRUMENTS
+3.8%
BLANK CHECKS
+2.8%
ELECTROMEDICAL & ELECTROTHERAPEUTIC APPARATUS
+1.8%