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SUTRO BIOPHARMA (STRO)

Earnings summaries and quarterly performance for SUTRO BIOPHARMA.

Recent press releases and 8-K filings for STRO.

Sutro Provides Pipeline and Financial Update at Healthcare Conference
STRO
New Projects/Investments
Guidance Update
Product Launch
  • Sutro announced that the first patient cohort has been dosed in the Phase 1 study for its tissue factor ADC, STRO-004, with top-line data anticipated by mid-2026.
  • The company plans to file an Investigational New Drug (IND) application for its integrin beta-6 ADC (STRO-006) in 2026 and is developing a dual payload ADC (STRO-227) targeting PTK7, designed to overcome resistance to single payload ADCs.
  • Sutro's cash runway has been extended into the middle of 2027, reflecting strategic efforts to reduce burn and externalize manufacturing.
  • In collaboration with Astellas, Sutro is advancing an immunostimulatory ADC program, with the first program expected to enter the clinic in early 2026.
5 days ago
Sutro Biopharma Details XpressCF Platform and Clinical Pipeline Progress
STRO
New Projects/Investments
Guidance Update
  • Sutro Biopharma's XpressCF platform enables the development of next-generation antibodies, including ADCs with 2-3 fold higher drug exposure and site-specific conjugation.
  • The company has dosed the first cohort of patients in its Phase 1 study for STRO-004, a tissue factor ADC, and anticipates top-line data by the middle of next year (mid-2026). STRO-004 is designed for improved safety and efficacy, with a high non-severely toxic dose (HNSTD) of 50 mg/kg.
  • Sutro plans to file an IND for its integrin beta-6 ADC (STRO-006) next year (2026) and is developing dual payload ADCs to overcome resistance to single payload ADCs.
  • The company's partnership with Astellas is developing immunostimulatory ADCs, with Astellas' first program expected to enter the clinic early next year (2026).
  • Sutro has extended its cash runway into the middle of 2027, not including potential milestones from partnerships.
5 days ago
Sutro Provides Update on XpressCF Platform, Clinical Pipeline, and Financial Runway
STRO
New Projects/Investments
Guidance Update
Product Launch
  • Sutro's XpressCF platform enables next-generation ADCs with enhanced drug exposure, site-specific conjugation, and dual payloads, aiming to overcome resistance to single payload ADCs.
  • The company has dosed the first cohort of patients in the Phase 1 study for its tissue factor ADC, STRO-004, with IND clearance in late October and top-line data anticipated by mid-2025.
  • Sutro plans to file an IND for an integrin beta-6 ADC next year and is developing a dual payload ADC (STRO-227) targeting PTK7, designed for improved efficacy and safety.
  • Sutro has extended its cash runway into mid-2027 by reducing burn and externalizing manufacturing, following a strategic pivot in March.
5 days ago
Sutro Biopharma Outlines Strategic Reset and Pipeline Advancements at 2025 R&D Day
STRO
New Projects/Investments
Management Change
Guidance Update
Nov 12, 2025, 3:00 PM
Sutro Biopharma Details Strategic Reset and Advances Differentiated ADC Pipeline at 2025 R&D Day
STRO
New Projects/Investments
Guidance Update
  • Sutro Biopharma has undergone a strategic reset, focusing on a differentiated Antibody-Drug Conjugate (ADC) pipeline and has extended its cash runway to the middle of 2027.
  • The lead program, STRO-004, a tissue factor ADC, is now active and enrolling in the clinic, with initial top-line data anticipated in mid-2026. Preclinical data showed a high non-severe toxic dose (HNSTD) of 50 mg/kg and anti-tumor activity at doses as low as 1 mg/kg.
  • The company is advancing STRO-006, an integrin beta-6 ADC, with an Investigational New Drug (IND) filing targeted for 2026.
  • Sutro is also progressing dual payload ADCs, including its first wholly-owned program targeting PTK7, aiming for clinic entry as early as 2026-2027, and an Astellas-partnered iADC program expected to enter the clinic in early 2026.
  • Sutro's ADC technology is designed to optimize every component (antibody, linker, payload) to achieve improved safety and efficacy, allowing for higher drug exposure and potentially overcoming resistance.
Nov 12, 2025, 3:00 PM
Sutro Details Strategic Reset and Clinical Pipeline Progress at R&D Day
STRO
New Projects/Investments
  • Sutro has completed a strategic reset with a new leadership team, reducing its workforce from approximately 350 FTEs to 130, and extending its cash runway to mid-2027.
  • The company's lead program, STRO-004, a tissue factor ADC, is now active and enrolling in the clinic, with initial top-line data expected in mid-2026.
  • Sutro's pipeline includes STRO-006 (integrin beta-6 ADC) with an IND planned for 2026, and its first wholly-owned dual payload PTK7 ADC aiming for clinic entry in 2026-2027.
  • An Astellas-partnered immunostimulatory ADC (iADC) program is also expected to enter the clinic in early 2026.
  • Sutro emphasizes its differentiated ADC technology, which allows for optimization of all components (antibody, linker, payload) to achieve higher drug exposure and a wider therapeutic window, particularly for dual payload ADCs designed to overcome resistance and improve efficacy.
Nov 12, 2025, 3:00 PM
Sutro Biopharma Reports Q3 2025 Financial Results and STRO-004 IND Clearance
STRO
Earnings
Guidance Update
New Projects/Investments
  • Sutro Biopharma reported cash, cash equivalents and marketable securities of $167.6 million as of September 30, 2025, with an expected cash runway into at least mid-2027 due to operational efficiencies and anticipated near-term milestone payments.
  • The company received U.S. FDA clearance of its Investigational New Drug (IND) application for STRO-004, its Tissue Factor ADC, and expects to dose the first patient before year-end 2025.
  • For the third quarter ended September 30, 2025, revenue was $9.7 million, an increase from $8.5 million in the prior year period, while total operating expenses decreased to $58.2 million from $76.4 million in Q3 2024.
Nov 6, 2025, 9:45 PM
Sutro Biopharma Reports Q3 2025 Results and STRO-004 IND Clearance
STRO
Earnings
New Projects/Investments
Guidance Update
  • Sutro Biopharma reported $167.6 million in cash, cash equivalents, and marketable securities as of September 30, 2025, with a cash runway projected into at least mid-2027.
  • The company received U.S. FDA clearance for its Investigational New Drug (IND) application for STRO-004, a Tissue Factor ADC, and anticipates dosing the first patient before year-end.
  • For the third quarter of 2025, revenue was $9.7 million, primarily from the Astellas collaboration, and total R&D and G&A expenses were $48.6 million.
  • Sutro will host a virtual R&D Day on November 12, 2025, to provide updates on its next-generation ADC programs.
Nov 6, 2025, 9:30 PM
Sutro Biopharma Announces Operational Restructuring
STRO
Layoffs
Guidance Update
New Projects/Investments
  • Sutro Biopharma, Inc. announced an operational restructuring to prioritize its three ADC programs and research and development collaborations.
  • This restructuring is expected to extend the company's cash runway into at least mid-2027.
  • The plan includes a workforce reduction of approximately one-third of employees.
  • Total estimated costs for the restructuring are between $4.1 million and $4.3 million, with the majority expected to be paid in Q4 2025.
  • The company anticipates initial clinical data from its STRO-004 program in 2026.
Sep 29, 2025, 9:15 PM
Sutro Biopharma Announces Organizational Restructuring
STRO
Layoffs
Guidance Update
  • Sutro Biopharma announced an organizational restructuring to prioritize its three antibody drug conjugate (ADC) programs and research and development collaborations.
  • This restructuring, along with expected near-term milestone payments, is anticipated to extend the company's cash runway into at least mid-2027.
  • The restructuring will result in a planned workforce reduction of approximately one-third of employees.
  • The company expects to announce initial clinical data from STRO-004 in 2026 and initiate clinical studies for at least one additional ADC program.
Sep 29, 2025, 9:05 PM

Quarterly earnings call transcripts for SUTRO BIOPHARMA.