Orbimed Advisors LLC
OrbiMed Advisors LLC is a leading healthcare-focused investment firm headquartered in New York, NY, United States. Founded in 1989, OrbiMed invests across the spectrum of public and private healthcare companies globally, from early-stage startups to large multinational corporations, with a team of over 130 professionals. It is considered one of the world's largest dedicated healthcare investment firms and serves institutions, family offices, and other sophisticated investors.
Investment Strategy
OrbiMed's investment strategy focuses exclusively on the healthcare sector, including biopharmaceuticals, medical devices, diagnostics, digital health, and healthcare services. The firm seeks to invest globally in innovative companies at all stages, from seed and venture capital to growth equity and public companies. OrbiMed emphasizes supporting groundbreaking technologies addressing unmet medical needs and improving patient outcomes across diverse geographies, leveraging a global team of scientific, medical, and investment professionals.
Latest 13F Filing Activity
Orbimed Advisors LLC filed their most recent 13F report on Jun 30, 2025 disclosing 94 equity positions and 5 options positions with a total 13F market value of $4B. The fund increased holdings in Caris Life Sciences Inc., Ars Pharmaceuticals Inc., Roivant Sciences LTD among other positions. Orbimed Advisors LLC reduced exposure to Edgewise Therapeutics Inc., Pfizer Inc., Ionis Pharmaceuticals Inc. among others.
Top Holdings
Equity Positions (94)
| Ticker | Security | Weight | Market Value | Shares | Avg Cost | Price | Change (QoQ) |
|---|---|---|---|---|---|---|---|
S SINX | SINOVAC BIOTECH LTD | 8.37% | $334.0M | 2,718,735 | $0.00 | $0.00 | $0 |
B BSX | BOSTON SCIENTIFIC CORP | 7.57% | $302.2M | 2,813,200 | $26.13 | $107.41 | +$18.4M |
L LLY | ELI LILLY & CO | 6.59% | $263.2M | 337,600 | $461.01 | $779.53 | -$15.7M |
E EWTX | EDGEWISE THERAPEUTICS INC | 5.10% | $203.4M | 15,518,492 | $30.53 | $13.11 | -$127.0M |
E ELVN | ENLIVEN THERAPEUTICS INC | 4.00% | $159.7M | 7,959,538 | $21.90 | $20.06 | +$3.0M |
Options Positions (5)
| Ticker | Security | Action | Type | Notional Value | Contracts | Underlying Price | Premium Paid | Change (Contracts) | Change (Value) |
|---|---|---|---|---|---|---|---|---|---|
U UNH | UNITEDHEALTH GROUP INC | New | Call | $15.6M | 500 | $311.97 | $311.97 | +500 | +$15.6M |
A AZN | ASTRAZENECA PLC | New | Call | $7.0M | 1,000 | $69.88 | $69.88 | +1,000 | +$7.0M |
C CGON | CG ONCOLOGY INC | New | Call | $3.9M | 1,500 | $26.00 | $26.00 | +1,500 | +$3.9M |
A APLS | APELLIS PHARMACEUTICALS INC | New | Call | $865.5K | 500 | $17.31 | $17.31 | +500 | +$865.5K |
I INMB | INMUNE BIO INC | New | Put | $115.5K | 500 | $2.31 | $2.31 | +500 | +$115.5K |