Twist Bioscience (TWST) Company Report

Twist Bioscience, an emerging leader in life science tools, leverages a semiconductor approach to DNA synthesis to serve diverse applications including therapeutic drug discovery and diagnostics.
The company pre-announced strong Q1 fiscal year results, reporting 17% year-over-year revenue growth, with 27% growth in DNA synthesis and protein solutions and 8% in NGS applications (or 18% excluding one transitioning customer).
Twist reiterated its goal to achieve adjusted EBITDA break-even in Q4 2026.
Its serviceable addressable market (SAM) is projected to expand significantly, from $2 billion in 2020 to $7 billion in 2025 and over $12 billion in 2030, primarily due to new product introductions.
AI-enabled drug discovery is a key growth driver, contributing $25 million to the $66 million order growth in FY 2025.

Jan 12, 2026, 10:15 PM

Transcript

Twist Bioscience Discusses Q1 2024 Performance and 2026 Outlook

TWST

Revenue Acceleration/Inflection

Guidance Update

Product Launch

Twist Bioscience pre-announced Q1 2024 revenue ahead of guidance, reporting $53 million from NGS applications and $52 million from DNA synthesis and protein solutions, contributing to 17% year-over-year growth and 12 consecutive quarters of revenue growth.
The company reiterated its target to achieve adjusted EBITDA break-even in Q4 2026, supported by gross margins exceeding 50% and disciplined operating expenses.
AI-enabled drug discovery was a significant growth driver in fiscal year 2025, contributing $25 million to order growth out of $66 million, leveraging Twist's platform for high-throughput data generation.
Twist Bioscience projects its serviceable addressable market (SAM) to expand significantly, from $2 billion in 2020 to an estimated $7 billion in 2025 and over $12 billion in 2030, driven by new product introductions.
The company achieved gross margins above 50% last year and expects 75%-80% of revenue growth to drop to the gross margin line long-term, with current capacity utilization at less than 50%.

Jan 12, 2026, 10:15 PM

Transcript

Twist Bioscience Pre-Announces Strong Q1 Results and Reiterates FY2026 Adjusted EBITDA Break-Even Target

TWST

Guidance Update

Revenue Acceleration/Inflection

New Projects/Investments

Twist Bioscience pre-announced strong Q1 (fiscal year) results, with $53 million in NGS application revenue and $52 million in DNA synthesis and protein solutions revenue, contributing to an overall 17% year-over-year growth and marking 12 consecutive quarters of revenue growth at a 24% CAGR.
The company reiterated its target to achieve Adjusted EBITDA break-even in Q4 2026 and reported that its gross margin was above 50% last year.
Twist Bioscience's serviceable addressable market (SAM) is projected to expand significantly, from $7 billion in 2025 to more than $12 billion in 2030, driven partly by new product introductions and AI-enabled drug discovery, which contributed $25 million to $66 million order growth in FY 2025.

Jan 12, 2026, 10:15 PM

Transcript

Twist Bioscience Announces Preliminary First Quarter Fiscal 2026 Revenue

TWST

Earnings

Guidance Update

Revenue Acceleration/Inflection

Twist Bioscience announced preliminary, unaudited revenue for the first quarter of fiscal 2026 ended December 31, 2025.
Total revenue for Q1 FY2026 was approximately $103.7 million (+/- $0.2 million), representing 17% growth compared to the same period of fiscal 2025, and came in ahead of guidance of $100 to $101 million.
DNA Synthesis and Protein Solutions revenue grew 27% to approximately $51.1 million (+/- $0.1 million) for the quarter.
NGS Applications revenue reached approximately $52.6 million (+/- $0.1 million), with an 18% growth excluding one large customer transitioning their assay.

Jan 12, 2026, 1:13 PM

8-K

Twist Bioscience Discusses Strong FY 2025 Performance and FY 2026 Outlook at Wolfe Research Conference

TWST

Guidance Update

Revenue Acceleration/Inflection

New Projects/Investments

Twist Bioscience reported $99 million in Q4 and $376.6 million in FY 2025 revenue, exceeding initial guidance by $7 million at the midpoint, with gross margin growing 20 percentage points over two years to above 50%. The company targets adjusted EBITDA break-even by Q4 2026.
The Next-Generation Sequencing (NGS) segment grew over 20% in FY 2025 to $208 million, but FY 2026 guidance implies about 12% growth due to a single customer's transition from clinical trials to commercial ramp. Excluding this customer, NGS grew almost 20% in 2025 and is expected to maintain a similar growth rate in FY 2026.
The DNA Synthesis and Protein Solutions (DSPS) segment grew 17% in FY 2025 and is guided for about 16% growth in FY 2026, supported by a record pharma order in Q4 2025 providing visibility for the first half of FY 2026.
Starting fiscal Q1 2026, Twist will provide more detailed disclosures on customer groups (therapeutic, diagnostics, OEM/distributor, academic/government) and pricing insights to offer greater transparency into growth drivers.

Nov 17, 2025, 8:20 PM

Transcript

Twist Bioscience Discusses Strong 2025 Performance and 2026 Outlook at Wolfe Research Conference

TWST

Guidance Update

Revenue Acceleration/Inflection

New Projects/Investments

Twist Bioscience reported $99 million in Q4 and $376.6 million for the full year 2025, exceeding its initial guidance by $7 million at the midpoint despite a challenging economic environment.
The company has significantly improved its gross margin by 20 points over the last two years, now exceeding 50%, and anticipates reaching Agility Beta Break-Even in Q4 2026. OPEX remained flat or slightly decreased from 2022 to 2025 while revenue grew 85%.
The Next-Generation Sequencing (NGS) segment's 12% growth guidance for fiscal year 2026 is impacted by a single customer's transition from clinical trials to commercial ramp, which is causing sequential noise from Q4 to Q1; excluding this customer, the NGS business grew almost 20% in 2025 and is expected to grow similarly in FY26.
Growth in the DNA Synthesis and Protein Solutions (DSPS) segment, which grew 17% last year and is guided for 16% growth this year, is driven by winning in the therapeutics area and the fragment market, leading to a lower average selling price (ASP) per gene, which the company views as a positive indicator of market penetration.
Starting fiscal Q1, Twist plans to introduce new disclosures on customer groups, including therapeutic, diagnostics, OEM, distributor, academic, and government segments, to provide more detailed insights into its growth drivers.

Nov 17, 2025, 8:20 PM

Transcript

Twist Reports Strong FY2025 Results, Updates 2026 Guidance, and Shifts R&D Focus

TWST

Guidance Update

Revenue Acceleration/Inflection

Demand Weakening

Twist reported Q4 revenue of $99 million and FY 2025 revenue of $376.6 million, exceeding its initial guidance midpoint by approximately $7 million.
The company significantly improved its gross margin by 20 points over the last two years, reaching above 50%, and targets adjusted EBITDA breakeven in Q4 2026.
The NGS segment grew over 20% in FY 2025 to $208 million (approximately 55% of sales), with a 12% growth projected for FY 2026, impacted by a single customer's transition from clinical trials to commercial ramp.
The DNA synthesis and protein solutions (DSPS) segment grew 17% last year (approximately 45% of sales) and is guided for 16% growth in FY 2026, supported by a significant pharma order in Q4 2025.
Twist is strategically refocusing its R&D efforts towards revenue growth, having successfully optimized gross margins to above 50%.

Nov 17, 2025, 8:20 PM

Transcript

Twist Discusses Strong FY2025 Performance, NGS Customer Impact, and 2026 Outlook

TWST

Guidance Update

Revenue Acceleration/Inflection

New Projects/Investments

Twist reported Q4 revenue of $99 million and FY2025 revenue of $376.6 million, exceeding initial guidance. The company has significantly improved its gross margin by 20 percentage points over the last two years to above 50% and aims for adjusted EBITDA break-even in Q4 2026.
The Next-Generation Sequencing (NGS) segment, which accounted for $208 million (55% of sales) and grew over 20% last year, is guided for approximately 12% growth in FY2026. This guidance is impacted by a single customer transitioning from clinical trials to commercial ramp, which caused a sequential drop from Q4 to Q1; excluding this customer, the NGS business grew almost 20% in 2025 and is expected to do so in 2026. This customer represents $5 million or more per quarter.
The DNA Synthesis and Protein Solutions (DSPS) segment, representing 45% of sales, grew 17% last year and is guided for about 16% growth this year. A pretty big pharma order in Q4, a new record for the company, provides strong visibility for the first half of the year in this segment. The price per gene was down about 11% in Q4 primarily due to increased wins in the therapeutics area and the fragments market.
Twist achieved 85% revenue growth from 2022 to 2025 while maintaining flat OPEX (down $1 million) and improving gross margin from under 30% to over 50%. With gross margins now above 50%, the company plans to refocus R&D efforts towards revenue growth.

Nov 17, 2025, 8:20 PM

Transcript

Twist Discusses Strong FY2025 Performance and 2026 Outlook at Wolfe Research Conference

TWST

Guidance Update

Revenue Acceleration/Inflection

New Projects/Investments

Twist reported $99 million in revenue for Q4 2025 and $376.6 million for fiscal year 2025, exceeding its initial guidance midpoint by $7 million despite a challenging economic environment.
The company has significantly improved its gross margin by 20 points over the last two years, reaching over 50%.
Twist aims to achieve Agility Beta Break-Even in Q4 2026, having reduced its loss to $8 million in the last quarter.
The Next-Generation Sequencing (NGS) segment's Q4 to Q1 sequential drop and 2026 guidance are impacted by a single customer transitioning from clinical trials to commercial ramp; however, the business, excluding this customer, is growing at nearly 20%.
The DNA Synthesis and Protein Solutions (DSPS) segment secured a record-breaking pharma order in Q4 2025, providing strong visibility for the first half of 2026, with a lower average selling price (ASP) driven by winning in therapeutics/AI and fragment markets.

Nov 17, 2025, 8:20 PM

Transcript

Twist Bioscience Discusses FY25 Performance and 2026 Outlook at Wolfe Research Conference

TWST

Guidance Update

Revenue Acceleration/Inflection

New Projects/Investments

Twist Bioscience reported $99 million in Q4 revenue and $376.6 million for the full year 2025, exceeding its initial guidance by $7 million at the midpoint.
The company achieved a 20 percentage point increase in gross margin over the last two years, now exceeding 50%, and aims for adjusted EBITDA break-even by Q4 2026.
The Next-Generation Sequencing (NGS) segment grew over 20% in FY 2025 to $208 million but is guided to about 12% growth for FY 2026 due to a specific customer's transition from clinical trials to commercialization. Excluding this customer, NGS growth is closer to 20%.
The DNA Synthesis and Protein Solutions (DSPS) segment grew 17% in FY 2025 and is guided for about 16% growth in FY 2026, bolstered by a record pharma order in Q4 2025 that provides strong visibility for the first half of 2026.
The 11% decline in price per gene in Q4 2025 for DSPS is attributed to increased sales in therapeutics and the fragment market, which the company views as a positive indicator of market penetration.

Nov 17, 2025, 8:20 PM

Transcript

Earnings Transcripts

Quarterly earnings call transcripts for Twist Bioscience.

Q4 2025

Nov 14, 2025

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Q3 2025

Aug 4, 2025

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Q2 2025

May 5, 2025

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Twist Bioscience (TWST)

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Adam Laponis

Dennis Cho

Patrick Finn

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