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    AMGEN (AMGN)

    Amgen Inc. is a global biotechnology company that discovers, develops, manufactures, and delivers innovative medicines to address serious diseases . The company operates in the human therapeutics segment, focusing on areas of high unmet medical need . Amgen's principal products include Prolia, ENBREL, XGEVA, Repatha, Otezla, TEPEZZA, EVENITY, KYPROLIS, Nplate, Aranesp, KRYSTEXXA, BLINCYTO, Vectibix, and TEZSPIRE, among others . The company's strategy includes expanding its rare disease portfolio, bolstered by the acquisition of Horizon Therapeutics .

    1. Human Therapeutics - Focuses on developing and delivering medicines for serious diseases, with key products like Prolia, ENBREL, XGEVA, Repatha, and Otezla driving growth.
      • Prolia - Treats osteoporosis by increasing bone mass and strength.
      • ENBREL - Used for treating autoimmune diseases such as rheumatoid arthritis.
      • XGEVA - Prevents skeletal-related events in patients with bone metastases.
      • Repatha - Lowers cholesterol levels in patients with cardiovascular risks.
      • Otezla - Treats moderate to severe plaque psoriasis and psoriatic arthritis.
    2. Rare Disease Portfolio - Expanded through the acquisition of Horizon Therapeutics, focusing on rare diseases with products like TEPEZZA, KRYSTEXXA, and UPLIZNA.
      • TEPEZZA - Treats thyroid eye disease.
      • KRYSTEXXA - Manages chronic gout in adult patients.
      • UPLIZNA - Targets neuromyelitis optica spectrum disorder.
    3. Oncology and Hematology - Develops treatments for cancer and blood disorders, including products like KYPROLIS, Nplate, Aranesp, and BLINCYTO.
      • KYPROLIS - Used in the treatment of multiple myeloma.
      • Nplate - Increases platelet production in patients with chronic immune thrombocytopenia.
      • Aranesp - Treats anemia associated with chronic kidney disease and chemotherapy.
      • BLINCYTO - Engages the immune system to target and destroy leukemia cells.
    4. Bone Health - Offers treatments like EVENITY and Vectibix to improve bone health and treat bone-related conditions.
      • EVENITY - Increases bone formation and reduces the risk of fractures in osteoporosis.
      • Vectibix - Used in the treatment of metastatic colorectal cancer.
    5. Respiratory and Inflammatory Diseases - Provides solutions for respiratory and inflammatory conditions, with products like TEZSPIRE.
      • TEZSPIRE - Treats severe asthma by targeting inflammatory pathways.

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    NamePositionExternal RolesShort Bio

    Robert A. Bradway

    ExecutiveBoard

    Chairman, CEO, and President

    Director at The Boeing Company; Trustee of the University of Southern California (USC)

    Joined Amgen in 2006. Held roles including CFO, COO, and President. CEO since 2012 and Chairman since 2013. Extensive leadership in operations, strategy, and finance.

    View Report →

    David M. Reese

    Executive

    EVP and Chief Technology Officer

    None

    Joined Amgen in 2005. Former EVP of R&D. Leads technology and AI initiatives across Amgen.

    Derek Miller

    Executive

    SVP, Human Resources

    None

    Joined Amgen in 2003. Held various HR leadership roles. SVP since 2022.

    Esteban Santos

    Executive

    EVP, Operations

    None

    Joined Amgen in 2007. Held various leadership roles in manufacturing and operations. EVP since 2016.

    Murdo Gordon

    Executive

    EVP, Global Commercial Operations

    None

    Joined Amgen in 2018. Previously Chief Commercial Officer at Bristol-Myers Squibb. Leads Amgen's global commercial strategy.

    Nancy A. Grygiel

    Executive

    SVP and Chief Compliance Officer

    None

    Joined Amgen in 2015. Former VP of Compliance at Allergan. Chief Compliance Officer since 2020.

    Peter H. Griffith

    Executive

    EVP and CFO

    None

    Joined Amgen in 2019. Former partner at EY and President of Sherwood Canyon Group. CFO since 2020.

    Rachna Khosla

    Executive

    SVP, Business Development

    None

    Joined Amgen in 2013. Leads business development efforts, including collaborations and acquisitions.

    Amy E. Miles

    Board

    Director

    Chair of Norfolk Southern; Director at The Gap; Trustee of Boys and Girls Club of Eastern Tennessee

    Director since 2020. Former CEO of Regal Entertainment Group. Expertise in finance and governance.

    Brian J. Druker

    Board

    Director

    Director at Vincerx Pharma; CEO of OHSU Knight Cancer Institute; Scientific Advisor at Blueprint Medicines

    Director since 2018. Renowned oncologist and researcher. Founder of Blueprint Medicines and MolecularMD.

    Charles M. Holley

    Board

    Director

    Director at Carrier Global and Phillips 66; Advisory roles at University of Texas

    Director since 2017. Former CFO of Walmart. Expertise in finance and governance.

    Ellen J. Kullman

    Board

    Director

    Lead Independent Director at Dell Technologies; Director at Goldman Sachs; Executive Chair at Carbon

    Director since 2016. Former CEO of DuPont. Expertise in governance and business leadership.

    Greg C. Garland

    Board

    Director

    Executive Chairman of Phillips 66; Member of MD Anderson Board of Visitors; Vice Chair of Barbara Bush Literacy Foundation

    Director since 2013. Former CEO of Phillips 66. Expertise in energy, governance, and sustainability.

    Mary E. Klotman

    Board

    Director

    EVP for Health Affairs at Duke University; Dean of Duke University School of Medicine

    Director since 2024. Renowned academic leader and physician-scientist. Expertise in medicine and research.

    Michael V. Drake

    Board

    Director

    President of the University of California system

    Director since 2022. President of the University of California. Former President of The Ohio State University.

    Robert A. Eckert

    Board

    Lead Independent Director

    Director at Levi Strauss & Co. and Uber Technologies; Operating Partner at FFL Partners

    Director since 2012. Former CEO of Mattel. Extensive experience in governance and business leadership.

    S. Omar Ishrak

    Board

    Director

    Director at Intel Corporation and Allurion Technologies; Senior Advisor at Blackstone Life Sciences

    Director since 2021. Former CEO of Medtronic. Expertise in healthcare and technology.

    Tyler Jacks

    Board

    Director

    Director at Thermo Fisher Scientific; President of Break Through Cancer; Chair of Dragonfly Therapeutics

    Director since 2012. Renowned cancer researcher and academic leader.

    Wanda M. Austin

    Board

    Director

    Director at Apple Inc. and Chevron Corporation; Co-founder of MakingSpace, Inc.; USC Life Trustee

    Director since 2017. Former CEO of Aerospace Corporation. Extensive experience in STEM education and governance.

    1. Non-GAAP operating expenses increased 30% year-over-year, driven by higher R&D and SG&A spending, including investments in Repatha, Otezla, and EVENITY. How do you plan to manage these increasing expenses to maintain your operating margin, and when do you expect to see a return on these investments?

    2. The Horizon acquisition resulted in a $700 million OI&E expense, up $400 million year-over-year due to increased interest expenses. Can you elaborate on your deleveraging plan to retire over $10 billion of debt by the end of 2025, and how this will impact your financial flexibility and capital allocation priorities?

    3. With Enbrel facing competition in a crowded market and the CMS price negotiations concluding with a price reduction affecting approximately 25% of its revenues from Medicare Part D, what strategies are you implementing to sustain Enbrel's performance, and how are you mitigating the potential impact of Part D redesign on its future sales?

    4. You are significantly ramping up investment in your late-stage pipeline, including MariTide for obesity and Type 2 diabetes, and rocatinlumab for atopic dermatitis. Given the competitive landscape in these areas, how confident are you in the potential success of these programs, and what differentiates your candidates from existing therapies?

    5. Despite the strong initial uptake of IMDELLTRA since its mid-May launch, what challenges do you anticipate in its adoption, given the need for monitoring and establishing new care pathways, and how do you plan to address these to maximize its market potential?

    Research analysts who have asked questions during AMGEN earnings calls.

    Jay Olson

    Oppenheimer & Co. Inc.

    4 questions for AMGN

    Also covers: ACAD, BIIB, BNTX +22 more

    Salveen Richter

    Goldman Sachs

    4 questions for AMGN

    Also covers: ACAD, AGIO, ALLO +19 more

    Terence Flynn

    Morgan Stanley

    4 questions for AMGN

    Also covers: ABBV, ARVN, BIIB +17 more

    Yaron Werber

    TD Cowen

    4 questions for AMGN

    Also covers: ALEC, ARGX, ASND +14 more

    Alexandria Hammond

    Wolfe Research

    3 questions for AMGN

    Also covers: ABBV, BMRN, GILD +5 more

    Christopher Schott

    JPMorgan Chase & Co.

    3 questions for AMGN

    Also covers: ABBV, AMRX, BIIB +13 more

    Courtney Breen

    AllianceBernstein

    3 questions for AMGN

    Also covers: ABBV, BMY, GILD +4 more

    David Amsellem

    Piper Sandler Companies

    3 questions for AMGN

    Also covers: ALKS, AMPH, AMRX +26 more

    Evan Seigerman

    BMO Capital Markets

    3 questions for AMGN

    Also covers: ABBV, ARVN, BIIB +15 more

    Gregory Renza

    RBC Capital Markets

    3 questions for AMGN

    Also covers: ACAD, ADCT, AGIO +12 more

    Michael Yee

    Jefferies

    3 questions for AMGN

    Also covers: ALLO, BEAM, BIIB +14 more

    Umer Raffat

    Evercore ISI

    3 questions for AMGN

    Also covers: ALKS, BHC, BIIB +14 more

    Carter L. Gould

    Barclays

    2 questions for AMGN

    Also covers: ABBV, ALEC, BMY +7 more

    David Risinger

    Leerink Partners

    2 questions for AMGN

    Also covers: ABBV, BMY, HALO +8 more

    Matthew Phipps

    William Blair

    2 questions for AMGN

    Also covers: AGEN, ARGX, AUTL +6 more

    Mohit Bansal

    Wells Fargo & Company

    2 questions for AMGN

    Also covers: ABBV, BMRN, BMY +16 more

    Chris Schott

    JPMorgan Chase & Co.

    1 question for AMGN

    Also covers: ABBV, BMY, GILD +11 more

    Christopher Raymond

    Piper Sandler

    1 question for AMGN

    Also covers: ABBV, AGIO, ARDX +5 more

    Conor MacKay

    BMO Capital Markets

    1 question for AMGN

    Also covers: ABCL, ARVN, INCY

    Geoff Meacham

    Citigroup Inc.

    1 question for AMGN

    Also covers: BMY, GILD, KNSA +5 more

    James Shin

    Analyst

    1 question for AMGN

    Also covers: ABBV, AUTL, BMY +7 more

    Luca Issi

    RBC Capital Markets

    1 question for AMGN

    Also covers: ADVM, ALLO, ALNY +12 more

    Matt Phipps

    William Blair

    1 question for AMGN

    Also covers: AUTL, DVAX, GMAB +3 more

    Olivia Brayer

    Cantor

    1 question for AMGN

    Also covers: AUPH, BMRN, BMY +7 more

    Sadia Rahman

    Wells Fargo

    1 question for AMGN

    Also covers: HALO, MLYS, TVTX

    Timothy Anderson

    BofA Securities

    1 question for AMGN

    Also covers: ABBV, AZN, BIIB +10 more

    Trung Huynh

    UBS Group AG

    1 question for AMGN

    Also covers: ABBV, ABOS, BMY +5 more
    Program DetailsProgram 1
    Approval DateN/A
    End Date/DurationN/A
    Total Additional AmountN/A
    Remaining Authorization$7.0 billion
    DetailsNo repurchase activity during the nine months ended September 30, 2024
    YearAmount Due (in billions)Debt TypeInterest Rate (%)% of Total Debt
    20253.5441.90%, 5.25%, 3.125% Notes1.90, 5.25, 3.1255.9% = (3.544 / 60.398) * 100
    20264.2202.00% (€750M), 5.507%, 2.60%, 5.50% (£475M) Notes2.00, 5.507, 2.60, 5.507.0% = (4.220 / 60.398) * 100
    20272.7242.20%, 3.20% Notes2.20, 3.204.5% = (2.724 / 60.398) * 100
    20284.9845.15%, 1.65% Notes5.15, 1.658.3% = (4.984 / 60.398) * 100
    20292.9363.00%, 4.05%, 4.00% (£700M) Notes3.00, 4.05, 4.004.9% = (2.936 / 60.398) * 100
    20304.0002.45%, 5.25% Notes2.45, 5.256.6% = (4.000 / 60.398) * 100
    20311.2502.30% Notes2.302.1% = (1.250 / 60.398) * 100
    20322.0012.00%, 3.35% Notes2.00, 3.353.3% = (2.001 / 60.398) * 100
    20335.0004.20%, 5.25% Notes4.20, 5.258.3% = (5.000 / 60.398) * 100
    20370.4786.375% Notes6.3750.8% = (0.478 / 60.398) * 100
    20380.2546.90% Notes6.900.4% = (0.254 / 60.398) * 100
    20390.3336.40% Notes6.400.6% = (0.333 / 60.398) * 100
    20402.0413.15%, 5.75% Notes3.15, 5.753.4% = (2.041 / 60.398) * 100
    20412.1052.80%, 4.95%, 5.15% Notes2.80, 4.95, 5.153.5% = (2.105 / 60.398) * 100
    20420.4155.65% Notes5.650.7% = (0.415 / 60.398) * 100
    20432.9355.60%, 5.375% Notes5.60, 5.3754.9% = (2.935 / 60.398) * 100
    20452.2504.40% Notes4.403.7% = (2.250 / 60.398) * 100
    20481.4154.563% Notes4.5632.3% = (1.415 / 60.398) * 100
    20501.7643.375% Notes3.3752.9% = (1.764 / 60.398) * 100
    20513.5414.663% Notes4.6635.9% = (3.541 / 60.398) * 100
    20521.7853.00%, 4.20% Notes3.00, 4.203.0% = (1.785 / 60.398) * 100
    20536.1904.875%, 5.65%, 2.77% Notes4.875, 5.65, 2.7710.2% = (6.190 / 60.398) * 100
    20621.1654.40% Notes4.401.9% = (1.165 / 60.398) * 100
    20632.7505.75% Notes5.754.6% = (2.750 / 60.398) * 100
    20970.1008.125% Debentures8.1250.2% = (0.100 / 60.398) * 100

    Competitors mentioned in the company's latest 10K filing.

    CompanyDescription

    Competes with the company in the U.S. with HUMIRA and RINVOQ for ENBREL, and HUMIRA, Skyrizi, and SOTYKTU for Otezla. HUMIRA biosimilars are also approved.

    Competes with the company in the U.S. with Xeljanz for ENBREL and BESPONSA for BLINCYTO.

    Competes with the company in the U.S. and Europe with Cosentyx and LEQVIO for Otezla and Repatha, respectively, and PROMACTA/REVOLADE for Nplate.

    Competes with the company in the U.S. and Europe with Taltz for Otezla and ERBITUX for Vectibix.

    Janssen

    Competes with the company in the U.S. and Europe with Tremfya and DARZALEX for Otezla and KYPROLIS, respectively, and PROCRIT for Aranesp. Janssen is a subsidiary of Johnson & Johnson.

    Competes with the company in the U.S. and Europe with SOTYKTU for Otezla and POMALYST/IMNOVID for KYPROLIS.

    Competes with the company in the U.S., Europe, and Asia Pacific with PRALUENT for Repatha.

    Millennium Pharmaceuticals, Inc.

    Competes with the company in the U.S. with VELCADE for KYPROLIS. Millennium Pharmaceuticals is a subsidiary of Takeda Pharmaceutical Company Limited.

    F. Hoffmann-La Roche Ltd (Roche)

    Competes with the company in the U.S. and Europe with Avastin for Vectibix.

    Competes with the company in the U.S. with KEYTRUDA for Vectibix.

    Various

    Competes with the company in multiple territories with generic versions of bisphosphonates for Prolia and EVENITY, zoledronate generics for XGEVA, etanercept biosimilars for ENBREL in Canada, and chemotherapy regimens for Vectibix and BLINCYTO.

    Asahi Kasei Pharma

    Competes with the company in Japan with Teribone for EVENITY.

    Celgene

    Competes with the company in the U.S. and Europe with POMALYST/IMNOVID for KYPROLIS. Celgene is a subsidiary of Bristol Myers Squibb Company.

    CustomerRelationshipSegmentDetails

    McKesson Corporation

    Major pharmaceutical wholesale distributor

    All

    Contributed 33% of total gross revenues in 2024 ($22,173M). Part of 70% of net trade receivables in 2024.

    Cencora, Inc.

    Major pharmaceutical wholesale distributor

    All

    Contributed 27% of total gross revenues in 2024 ($18,387M). Part of 70% of net trade receivables in 2024.

    Cardinal Health, Inc.

    Major pharmaceutical wholesale distributor

    All

    Contributed 17% of total gross revenues in 2024 ($11,278M). Part of 70% of net trade receivables in 2024.

    NameStart DateEnd DateReason for Change
    Ernst & Young LLP1980 PresentCurrent auditor

    Notable M&A activity and strategic investments in the past 3 years.

    CompanyYearDetails

    Horizon Therapeutics plc

    2023

    Amgen acquired Horizon for $116.50 per share in cash, amounting to a total equity value of about $27.8 billion, with the deal completed on October 6, 2023. The acquisition was strategically aimed at enhancing Amgen’s portfolio in rare, autoimmune, and severe inflammatory diseases by adding key products like TEPEZZA®, KRYSTEXXA®, and UPLIZNA®, while overcoming FTC regulatory challenges via a consent order agreement.

    ChemoCentryx, Inc.

    2022

    Amgen’s acquisition of ChemoCentryx was executed at $52.00 per share in cash, representing an aggregate merger consideration of roughly $3.7 billion, with the transaction completed on October 20, 2022. This deal strategically expands Amgen’s pipeline in inflammation and nephrology by adding TAVNEOS® (avacopan) and several early-stage drug candidates, and involved integrating ChemoCentryx as a wholly owned subsidiary.

    Recent press releases and 8-K filings for AMGN.

    Amgen details FY 2025 Q2 performance and pipeline catalysts at Wells Fargo Healthcare Conference
    ·$AMGN
    • Q2 FY 25 results: 9% revenue growth, 13% volume growth, 21% non-GAAP EPS growth y/y.
    • Key product momentum: Repatha sales of $689 M (+31% y/y), Evenity $518 M (+32%), rare disease portfolio annualizing >$5 B; oncology BiTEs Blincyto +45% y/y and Imdeltra $134 M (+65% q/q); TESPIRA +46% y/y in severe asthma.
    • Pipeline catalysts: Phase III obesity candidate meratide advancing; PDUFA for aplisna in gMG in December 2025 and Imdeltra in 2L SCLC on December 18; TESPIRA PDUFA in chronic rhinosinusitis with nasal polyps in October; ongoing Phase III opasiran cardiovascular outcomes study.
    • Capital allocation: R&D spend raised to >20% of revenues; Horizon transaction deleveraging largely complete and on track to restore pre-transaction leverage by year-end; continued dividends and share repurchases.
    Sep 3, 2025, 3:14 PM
    Henlius and Organon gain FDA approval for denosumab biosimilars
    ·$AMGN
    Product Launch
    • FDA approved BILDYOS® (denosumab-nxxp) 60 mg/mL and BILPREVDA® (denosumab-nxxp) 120 mg/1.7 mL, biosimilars to PROLIA and XGEVA, for all indications of the reference products.
    • BILDYOS is indicated for postmenopausal women with osteoporosis at high risk for fracture; increasing bone mass in men with osteoporosis, glucocorticoid-induced osteoporosis, androgen deprivation therapy-related bone loss, and adjuvant aromatase inhibitor-induced bone loss.
    • BILPREVDA is indicated for prevention of skeletal-related events in multiple myeloma and solid tumor bone metastases, giant cell tumor of bone, and hypercalcemia of malignancy.
    • Approvals were supported by analytical, pharmacokinetic, and comparative clinical data demonstrating high similarity and no clinically meaningful differences to PROLIA and XGEVA.
    • The approvals bolster Organon’s US biosimilars portfolio across five therapeutic areas, expanding access and affordability.
    Sep 2, 2025, 9:30 AM
    Amgen gains EU approval for TEVIMBRA in perioperative NSCLC
    ·$AMGN
    Product Launch
    • The European Commission approved TEVIMBRA (tislelizumab) as neoadjuvant therapy in combination with platinum-based chemotherapy, followed by adjuvant monotherapy for resectable NSCLC patients at high risk of recurrence.
    • Approval is based on final RATIONALE-315 analysis showing overall survival benefit in the perioperative setting for resectable NSCLC.
    • TEVIMBRA’s EU label now covers nine solid tumor indications, including five in lung cancer, highlighting its broad clinical profile.
    • Data will be presented at the WCLC 2025 conference, showcasing the latest results.
    Aug 28, 2025, 12:15 AM
    Amgen’s IMDELLTRA licensing rights deal announced
    ·$AMGN
    New Projects/Investments
    • Royalty Pharma agrees to acquire worldwide (ex-China) license royalties for IMDELLTRA from BeOne Medicines for up to $950 million, including an $885 million upfront payment and an option for the remaining $65 million within 12 months.
    • BeOne will receive royalties on annual net sales exceeding $1.5 billion under the agreement.
    • IMDELLTRA (tarlatamab-dlle) is a novel DLL3-targeting bispecific T-cell engager approved in the US for extensive-stage small-cell lung cancer after progression on platinum-based chemotherapy.
    Aug 25, 2025, 2:15 PM
    Amgen expands Repatha indication to broader high-risk adult population
    ·$AMGN
    • FDA broadens Repatha indication to adults at increased risk of major adverse cardiovascular events (MACE) due to uncontrolled LDL-C, removing the requirement for existing cardiovascular disease.
    • Repatha monotherapy is now approved for adults with homozygous familial hypercholesterolemia (HoFH) and continues to be recommended alongside diet and exercise for cholesterol management.
    • Since its initial approval in 2015, Repatha has been used by over 5 million patients and evaluated in 50 clinical trials with more than 57,000 participants over 15 years.
    • Repatha holds approvals in 74 countries, including major markets such as the U.S., Japan, Canada, and all EU member states, with further regulatory submissions pending.
    Aug 25, 2025, 1:00 PM
    Amgen cancer drug Imdelltra royalties sold to Royalty Pharma
    ·$AMGN
    M&A
    • BeOne Medicines agreed to sell non-China royalty rights on Amgen’s Imdelltra to Royalty Pharma for $885 million upfront, with an option to sell up to $65 million more within 12 months (total up to $950 million).
    • Imdelltra is a first-in-class DLL3-targeting BiTE immunotherapy for extensive-stage small cell lung cancer, developed by Amgen with BeOne holding a stake.
    • The deal bolsters BeOne’s financial position and strategic flexibility, while enhancing Royalty Pharma’s long-term growth and portfolio diversification.
    Aug 25, 2025, 10:08 AM
    TScan Therapeutics reports Q2 2025 results and corporate update
    ·$AMGN
    Earnings
    New Projects/Investments
    • TScan reported Q2 2025 revenue of $3.1 M (vs. $0.5 M in Q2 2024), R&D expenses of $32.6 M, G&A of $9.1 M, and a net loss of $37.0 M.
    • As of June 30, 2025, cash, cash equivalents, and marketable securities totaled $218.0 M, funding operations into Q1 2027.
    • The company expects to dose its first solid tumor patients with multiplex TCR-T in Q3 2025 and to share initial safety and response data in Q1 2026.
    • Upcoming milestones include initiating a registrational trial for TSC-101 and filing an IND for TSC-102-A0301 in H2 2025, with two-year relapse data from the ALLOHA Phase 1 trial by year-end.
    Aug 12, 2025, 11:09 AM
    Amgen announces Q2 2025 results
    ·$AMGN
    Earnings
    • Amgen reported Q2 revenue of $9.2 B (+9% YoY) with volume up 13% and generated $1.9 B free cash flow
    • Key growth products: Repatha $696 M (+31%), Evenity $518 M (+32%), rare disease portfolio $1.4 B (+19%), oncology $2.2 B (+14%), biosimilars $661 M (+40%)
    • R&D investment accelerated with $1.7 B spend (+18% YoY); advancing Meritide Phase 3 obesity trials, opaciran CVOT, and multiple BiTE programs
    • 2025 guidance: revenues $35–36 B, non-GAAP EPS $20.20–21.30, non-GAAP R&D growth >20%, OI&E ~$2.2 B, capex $2.3 B, dividend $2.38 (+6%)
    Aug 6, 2025, 12:00 AM
    Regeneron reports Q2 2025 financial results
    ·$AMGN
    Earnings
    Product Launch
    Share Buyback
    • Total revenues rose 4% to $3.68 billion in Q2 2025 versus Q2 2024.
    • GAAP EPS increased 3% to $12.81, while non-GAAP EPS grew 12% to $12.89.
    • Dupixent global net sales climbed 22% to $4.34 billion; EYLEA HD US net sales rose 29% to $393 million.
    • FDA approvals included Lynozyfic for relapsed/refractory multiple myeloma and new indications for Dupixent; Libtayo sBLA accepted for priority review in adjuvant CSCC.
    • Returned over $2.3 billion to shareholders via share repurchases and dividends, and committed over $7 billion to US manufacturing investments and business development since early 2025.
    Aug 1, 2025, 10:30 AM
    Amgen highlights PNH market barriers amidst emerging treatment options
    ·$AMGN
    • According to Spherix’s Q2 2025 RealTime Dynamix report, adoption of biosimilars (Bkemv and Epysqli) is projected to expand the treated PNH population beyond branded Soliris and Ultomiris due to cost-effectiveness and growing prescriber confidence.
    • Use of second-line therapies such as Fabhalta and Voydeya is increasing among patients who progress or are sub-optimally controlled on C5 inhibitors.
    • Nearly all prescribers report significant insurance-related challenges—including inconsistent prior authorization requirements, procurement delays, and AI-driven coverage restrictions—that delay patient access to PNH treatments.
    • Hematologists express strong interest in late-stage pipeline candidates like zaltenibart and pozelimab-cemdisiran, anticipating their adoption alongside existing therapies upon approval.
    Jul 8, 2025, 6:22 PM